Institution
Detroit Receiving Hospital
Healthcare•Detroit, Michigan, United States•
About: Detroit Receiving Hospital is a healthcare organization based out in Detroit, Michigan, United States. It is known for research contribution in the topics: Vancomycin & Population. The organization has 877 authors who have published 850 publications receiving 37202 citations. The organization is also known as: Detroit General.
Topics: Vancomycin, Population, Staphylococcus aureus, QRS complex, Daptomycin
Papers published on a yearly basis
Papers
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TL;DR: Precision and reproducibility are demonstrated as well as the absorption characteristics of the purple color produced through the spectral range of 400 to 700 mμ.
2,465 citations
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Harvard University1, McGill University2, University of Birmingham3, University College London4, University of Alabama at Birmingham5, McMaster University6, Dalhousie University7, Anschutz Medical Campus8, Mount Sinai St. Luke's and Mount Sinai Roosevelt9, Hospital for Special Surgery10, University of Michigan11, Detroit Receiving Hospital12, Johns Hopkins University13, Virginia Commonwealth University14, University of Texas at San Antonio15, University of Kiel16, Royal Stoke University Hospital17, University of British Columbia18, Henry Ford Health System19, University of California, Los Angeles20
TL;DR: The American College of Rheumatology Nomenclature for NPSLE provides case definitions for 19 neuropsychiatric syndromes seen in SLE, with reporting standards and recommendations for laboratory and imaging tests.
Abstract: OBJECTIVE
To develop a standardized nomenclature system for the neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE).
METHODS
An international, multidisciplinary committee representing rheumatology, neurology, psychiatry, neuropsychology, and hematology developed case definitions, reporting standards, and diagnostic testing recommendations. Before and after the meeting, clinician committee members assigned diagnoses to sets of vignettes randomly generated from a pool of 108 NPSLE patients. To assess whether the nomenclature system improved diagnostic agreement, a consensus index was developed and pre- and postmeeting scores were compared by t-tests.
RESULTS
Case definitions including diagnostic criteria, important exclusions, and methods of ascertainment were developed for 19 NPSLE syndromes. Recommendations for standard reporting requirements, minimum laboratory evaluation, and imaging techniques were formulated. A short neuropsychological test battery for the diagnosis of cognitive deficits was proposed. In the postmeeting exercise, a statistically significant improvement in diagnostic agreement was observed.
CONCLUSION
The American College of Rheumatology (ACR) Nomenclature for NPSLE provides case definitions for 19 neuropsychiatric syndromes seen in SLE, with reporting standards and recommendations for laboratory and imaging tests. It is intended to facilitate and enhance clinical research, particularly multicenter studies, and reporting. In clinical settings, consultation with other specialists may be required. It should be useful for didactic purposes but should not be used uncritically or as a substitute for a clinical diagnosis. The complete case definitions are available on the ACR World Wide Web site: http://www.rheumatology .org/ar/ar.html.
1,830 citations
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TL;DR: A literature review of existing evidence regarding vancomycin dosing and monitoring of serum concentrations, in addition to patient outcomes combined with expert opinion regarding the drug's pharmacokinetic, pharmacodynamic, and safety record, resulted in new recommendations for targeting and adjustment of vancomYcin therapy.
Abstract: Practice guidelines for therapeutic monitoring of vancomycin treatment for Staphylococcus aureus infection in adult patients were reviewed by an expert panel of the Infectious Diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists. A literature review of existing evidence regarding vancomycin dosing and monitoring of serum concentrations, in addition to patient outcomes combined with expert opinion regarding the drug's pharmacokinetic, pharmacodynamic, and safety record, resulted in new recommendations for targeting and adjustment of vancomycin therapy.
720 citations
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577 citations
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TL;DR: Findings support the notion that delay of therapy has deleterious effects on clinical outcomes, and efforts should be made to ensure that appropriate therapy is initiated promptly.
Abstract: The objective of this study was to determine the effect of delayed therapy on morbidity and mortality associated with nosocomial Staphylococcus aureus bacteremia. The study included all episodes of S. aureus bacteremia that developed >2 days after hospital admission during 1999 to 2001. Classification and regression tree analysis (CART) was used to select the mortality breakpoint between early and delayed treatment. During the 25-month study period, 167 patients met the inclusion criteria. The breakpoint between delayed and early treatment derived using CART was 44.75 hours. On multivariate analysis, delayed treatment was found to be an independent predictor of infection-related mortality (odds ratio, 3.8; 95% confidence interval, 1.3-11.0; P=.01) and was associated with a longer hospital stay than was early treatment (20.2 days versus 14.3 days; P=.05). These findings support the notion that delay of therapy has deleterious effects on clinical outcomes, and efforts should be made to ensure that appropriate therapy is initiated promptly.
571 citations
Authors
Showing all 878 results
Name | H-index | Papers | Citations |
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Ronald N. Jones | 109 | 1169 | 54206 |
Husseini K. Manji | 104 | 283 | 36624 |
Paul E. Marik | 89 | 621 | 32719 |
Michael J. Rybak | 77 | 420 | 24816 |
John M. Carethers | 52 | 199 | 9723 |
Renee C. LeBoeuf | 50 | 112 | 7017 |
John W. Devlin | 48 | 234 | 11941 |
Charles E. Lucas | 47 | 260 | 6768 |
Jan Paul Muizelaar | 47 | 99 | 10934 |
Vincent H. Tam | 45 | 184 | 7276 |
Berton R. Moed | 42 | 154 | 5311 |
James T. Fitzgerald | 42 | 120 | 7989 |
David Edelman | 38 | 165 | 5346 |
Donald P. Levine | 38 | 87 | 11611 |
Scott A. Dulchavsky | 38 | 130 | 5669 |