Institution
Donghua University
Education•Shanghai, China•
About: Donghua University is a education organization based out in Shanghai, China. It is known for research contribution in the topics: Fiber & Nanofiber. The organization has 21155 authors who have published 21841 publications receiving 393091 citations. The organization is also known as: Dōnghuá Dàxué & China Textile University.
Topics: Fiber, Nanofiber, Membrane, Electrospinning, Catalysis
Papers published on a yearly basis
Papers
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TL;DR: LbL functionalization of MSNs provides the practical possibility for creating MSN-based carrier systems with low systemic toxicity and high efficiency, and revealed that DOX-loaded PEM-MSNs had lower systemic toxicity than free DOX.
Abstract: Surface functionalization of mesoporous silica nanoparticles (MSNs) has been proposed as an efficient approach to enhance the biocompatibility and efficiency of MSN-based carrier systems. Herein, polyelectrolyte multilayers (PEMs) composed of poly(allylamine hydrochloride) (PAH) and poly(styrene sulfonate) (PSS) were coated onto the MSN surface via a layer-by-layer (LbL) technique, and doxorubicin hydrochloride (DOX) was loaded into the prepared PEM-MSNs, thus constructing potential pH-responsive carrier systems. Extensive studies were performed to evaluate their biocompatibility and efficiency, emphasizing the influences of the layer numbers on the release profiles, cytotoxicity and hemocompatibility. It is demonstrated that PEM layer thickness has an exponential relationship with the number of coated layers, and release profiles of nanoparticles were both pH- and layer thickness-dependent. PEM-MSNs exhibited a very low and layer thickness-dependent cytotoxicity against macrophage cells. They did not induce obvious hemolysis or cause significant platelet aggregation, but also did not activate any coagulation pathways. The cellular uptake of DOX-loaded PEM-MSNs in HeLa cells was remarkably larger than that in L929 cells, thus resulting in a desirable growth-inhibiting effect on cancer cells. DOX-loaded PEM-MSNs exhibited a slower and prolonged DOX accumulation in the nucleus than free DOX. In vivo biodistribution indicated that they induced a sustained drug concentration in blood plasma but lower drug accumulation in the major organs, especially in the heart, compared to free DOX. The histological results also revealed that DOX-loaded PEM-MSNs had lower systemic toxicity than free DOX. Therefore, LbL functionalization of MSNs provides the practical possibility for creating MSN-based carrier systems with low systemic toxicity and high efficiency.
123 citations
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TL;DR: In this paper, a new aqueous biphasic system (ABS) composed of hydrophilic ionic liquids (ILs) and sucrose was proposed, forming an upper IL-rich phase and a lower sucrose rich phase.
Abstract: In this work, we proposed a new aqueous biphasic system (ABS) composed of hydrophilic ionic liquids (ILs, namely, 1-allyl-3-methylimidazolium chloride, [Amim]Cl, 1-allyl-3-methylimidazolium bromide, [Amim]Br, and 1-butyl-3-methylimidazolium tetrafluoroborate, [Bmim]BF4) and sucrose, forming an upper IL-rich phase and a lower sucrose-rich phase The effects of IL structure on the phase equilibrium were investigated It was found that the formation of ABS could be promoted by the increase of the side-chain length of ILs, but the effect was weaker than that of the anion On the basis of phase diagrams we described, it was concluded that the chaotropicity decreased in the order [Bmim]BF4 > [Amim]Br > [Amim]Cl This is consistent with IL + salt systems with which they were compared; however, the proposed systems are more environmentally benign for separating ILs from the aqueous phase
123 citations
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TL;DR: In this paper, the authors have fabricated elastic solid electrolytes by filling ionic-conductive polymers into well-aligned Li6.4La3Zr2Al0.2O12 (LLZO) nanofiber films.
123 citations
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TL;DR: In this article, a plasmonic p-n heterojunction of Ag/Ag6Si2O7/Bi2MoO6 (AASO/BMO-3) was developed to eliminate environmental pharmaceutical pollutants.
123 citations
Authors
Showing all 21321 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dongyuan Zhao | 160 | 872 | 106451 |
Xiang Zhang | 154 | 1733 | 117576 |
Seeram Ramakrishna | 147 | 1552 | 99284 |
Kuo-Chen Chou | 143 | 487 | 57711 |
Shuai Liu | 129 | 1095 | 80823 |
Chao Zhang | 127 | 3119 | 84711 |
Tao Zhang | 123 | 2772 | 83866 |
Zidong Wang | 122 | 914 | 50717 |
Xinchen Wang | 120 | 349 | 65072 |
Zhenyu Zhang | 118 | 1167 | 64887 |
Benjamin S. Hsiao | 108 | 602 | 41071 |
Qian Wang | 108 | 2148 | 65557 |
Jian Zhang | 107 | 3064 | 69715 |
Yan Zhang | 107 | 2410 | 57758 |
Richard B. Kaner | 106 | 557 | 66862 |