Institution
Douglas Mental Health University Institute
Healthcare•Montreal, Quebec, Canada•
About: Douglas Mental Health University Institute is a healthcare organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Mental health & Population. The organization has 1415 authors who have published 2932 publications receiving 106947 citations. The organization is also known as: Douglas Hospital.
Papers published on a yearly basis
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University Hospital Bonn1, University of California, Riverside2, Harvard University3, Case Western Reserve University4, University of Illinois at Chicago5, European Institute6, Stanford University7, VA Palo Alto Healthcare System8, Spanish National Research Council9, Cleveland Clinic Lerner Research Institute10, Hong Kong University of Science and Technology11, University of California, Los Angeles12, University of Southern Denmark13, University of Cambridge14, University of Manchester15, University of the Basque Country16, Ikerbasque17, RIKEN Brain Science Institute18, University of Eastern Finland19, University of Massachusetts Medical School20, University of Bonn21, Center of Advanced European Studies and Research22, University of Southern California23, University of South Florida24, Duke University25, Southampton General Hospital26, University of Southampton27, Moorgreen Hospital28, Louisiana State University29, Imperial College London30, Centre national de la recherche scientifique31, Karolinska Institutet32, Max Planck Society33, University of Tübingen34, University of Groningen35, University of Colorado Denver36, Douglas Mental Health University Institute37
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Abstract: Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease.
3,947 citations
TL;DR: Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
Abstract: Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse alters HPA stress responses and increases the risk of suicide. We examined epigenetic differences in a neuron-specific glucocorticoid receptor (NR3C1) promoter between postmortem hippocampus obtained from suicide victims with a history of childhood abuse and those from either suicide victims with no childhood abuse or controls. We found decreased levels of glucocorticoid receptor mRNA, as well as mRNA transcripts bearing the glucocorticoid receptor 1F splice variant and increased cytosine methylation of an NR3C1 promoter. Patch-methylated NR3C1 promoter constructs that mimicked the methylation state in samples from abused suicide victims showed decreased NGFI-A transcription factor binding and NGFI-A–inducible gene transcription. These findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
3,087 citations
TL;DR: Improved recognition and understanding of clinical, psychological, sociological, and biological factors might help the detection of high-risk individuals and assist in treatment selection.
1,254 citations
Karolinska Institutet1, Karolinska University Hospital2, Pasteur Institute3, University of Toulouse4, Wolfson Centre for Age-Related Diseases5, University of Cambridge6, University of New South Wales7, Pierre-and-Marie-Curie University8, La Trobe University9, Umeå University10, University of British Columbia11, University of Geneva12, Douglas Mental Health University Institute13, Alzheimer Europe14, German Center for Neurodegenerative Diseases15, University of Cologne16, London School of Economics and Political Science17, Radboud University Nijmegen18, Rockefeller University19, VU University Medical Center20, University of Southern California21, Brigham and Women's Hospital22, University of Copenhagen23, University of Gothenburg24, UCL Institute of Neurology25
TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical and cognitive properties of Alzheimer's disease and other dementias.
Abstract: Defeating Alzheimer's disease and other dementias : a priority for European science and society
1,215 citations
TL;DR: It is shown that urban upbringing and city living have dissociable impacts on social evaluative stress processing in humans, and distinct neural mechanisms for an established environmental risk factor are identified.
Abstract: By 2050, two-thirds of the world's population will be living in cities Although city living has many advantages, rapidly increasing urbanization has major health implications schizophrenia is more common in people born in cities than in those from less heavily populated districts, and living in cities increases the rates of depression and anxiety disorders It has been suggested that social stress plays a part in these effects, but the mechanisms involved are unknown Now, in a study of healthy German volunteers using functional magnetic resonance imaging, a key brain structure for negative emotion (the amygdala) was found to be more active during stress in city dwellers, and a regulatory brain area (the cingulate cortex) more active in people born in cities These results identify potential mechanisms linking social environment and mental illness, and might contribute to planning healthier urban surroundings
1,172 citations
Authors
Showing all 1418 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Patrick D. McGorry | 137 | 1097 | 72092 |
| Michael J. Meaney | 136 | 604 | 81128 |
| Rémi Quirion | 101 | 516 | 36593 |
| Gustavo Turecki | 99 | 639 | 42223 |
| John C.S. Breitner | 93 | 349 | 32369 |
| Serge Gauthier | 93 | 637 | 52775 |
| Antoine Bechara | 93 | 268 | 53286 |
| David E. Bloom | 83 | 575 | 33536 |
| Jens C. Pruessner | 81 | 280 | 28326 |
| Isabelle Peretz | 81 | 299 | 23545 |
| Zafiris J. Daskalakis | 80 | 476 | 22074 |
| Yves Dauvilliers | 77 | 487 | 18882 |
| Brigitte L. Kieffer | 77 | 279 | 21082 |
| Lakshmi N. Yatham | 76 | 370 | 24219 |
| D. Louis Collins | 75 | 405 | 27634 |