Showing papers by "Drexel University published in 1969"
138 citations
Patent•
23 Oct 1969TL;DR: In this paper, the use of a low power narrow bandwidth light source with a red emission characteristic permits precise detection of the degree of oxygenation of the blood, and the output of the detector being connected to electronic circuitry for detecting pulse repetition rate of blood flow and for detecting signal level representative of the amount of oxygenated blood.
Abstract: Apparatus for detection of pulse repetition rate and oxygenation of blood flow, comprising a solid state probe having a narrow bandwidth light source housed to direct light upon a patient''s finger and a photodetector housed for receiving reflected light from such finger, the output of the detector being connected to electronic circuitry for detecting pulse repetition rate of blood flow and for detecting signal level representative of the degree of oxygenation of the patient''s blood. The use of a low power narrow bandwidth light source with a red emission characteristic permits precise detection of the degree of oxygenation of the blood.
105 citations
TL;DR: The cardiac hemodynamic findings suggest that the antihypertensive effect of Catapres is related to the combination of reduction in cardiac output plus decrease in peripheral resistance, which contrasts with the preservation of renal blood flow and glomerular filtration rate following acute administration of the drug.
Abstract: Catapres is a new imidazoline compound with potent antihypertensive properties. Significant reduction in blood pressure occurs between 1 and 4 hours after oral administration, with the peak effect occurring at 2 to 4 hours and the antihypertensive effect extending for 6 to 10 hours. Blood pressure is reduced in both the supine and erect positions, although the orthostatic response is the more prominent. Cardiac output is reduced moderately in both the supine and erect positions. Peripheral vascular resistance is also reduced, particularly in the erect posture. Accordingly, the cardiac hemodynamic findings suggest that the antihypertensive effect of Catapres is related to the combination of reduction in cardiac output plus decrease in peripheral resistance. Renal blood flow and glomerular filtration rate are preserved in both the supine and erect positions following Catapres administration. Contrasting with the preservation of renal blood flow and glomerular filtration rate, however, is the marked reductio...
104 citations
96 citations
TL;DR: In this article, a monomeric tetra-cordinated cations of the type [M(2,6-LNO) 4 ] 2+ (M = Fe, Co, Ni, Cu, Zn) were synthesized and studied.
82 citations
TL;DR: A reduction in HR, TTI, and LV dp/dt, determinants of myocardial oxygen consumption, concurrent with improved left ventricular function, demonstrates a beneficial synergistic hemodynamic action for nitroglycerin combined with propranolol.
Abstract: The hemodynamic effects of 10 mg of propranolol given intravenously (iv) were studied in 10 patients (group I) with coronary heart disease (CHD). These results were compared with the hemodynamic effects in a similar group of the nine (CHD) patients (group II) who were studied after administration of 0.6 mg of nitroglycerin and then after receiving 10 mg of propranolol iv with a second 0.6-mg dose of nitroglycerin. Measurements were obtained at rest and during exercise: before treatment, after nitroglycerin alone, after propranolol alone, and after nitroglycerin-propranolol in combination. Pretreatment exercise showed a 125% increase in mean pulmonary artery pressure (PAP) to 43 mm Hg and a 163% increase in left ventricular end-diastolic pressure (LVEDP) to 29 mm Hg. Nitroglycerin decreased PAP (–45%) and LVEDP (–66%); as did nitroglycerin-propranolol: PAP (–33%) and LVEDP (–38%). Nitroglycerin reduced tension-time index (TTI) –21%, and increased cardiac index (CI) +17%, heart rate (HR) +10%, left ventricular work index (LVWI) +11%, and left ventricular dp/dt (LV dp/dt) +22%. By contrast, nitroglycerin-propranolol reduced LVWI –14%, LV dp/dt –30%, TTI – 15%, and HR – 13% but did not significantly alter CI from pretreatment. Propranolol increased PAP to 40 mm Hg, did not change LVEDP at 29 mm Hg and decreased stroke index (SI) 16%. Nitroglycerin-propranolol diminished PA and LVED pressure and increased SI 14%. Effects of propranolol alone and of nitroglycerin-propranolol on HR, TTI, and LV dp/dt were not significantly different. Nitroglycerin-propranolol appears to have important advantages over nitroglycerin or propranolol alone. A reduction in HR, TTI, and LV dp/dt, determinants of myocardial oxygen consumption, concurrent with improved left ventricular function, demonstrates a beneficial synergistic hemodynamic action for nitroglycerin combined with propranolol.
78 citations
TL;DR: The purified β-1,4-Oligoglucan:orthophosphate glucosyltransferase from Clostridium thermocellum has been purified nearly 450-fold by a procedure which removes all known interfering enzymes.
70 citations
69 citations
TL;DR: Autoradiography of follicles labeled with H3-uridine either in vivo or by a “pulsechase” procedure in vitro indicated that, as in other polytrophic insect ovaries, the nurse cell nuclei are the most conspicuous source of oocyte RNA.
Abstract: Azure B staining of Cecropia moth ovarian follicles indicated that the pattern of RNA concentrations characteristic of vitellogenic oocytes is disrupted by a gross redistribution and dispersion, beginning with the final discharge of the cytoplasm of the nurse cells into the oocyte. The cytoplasmic redistribution is largely complete two days later when chorion formation begins, the germinal vesicle breaks down, and the first meiotic spindle forms.
At this stage the follicle contains 30 μg of RNA, of which 27 μg are in the follicle cells and only 3 μg in the oocyte itself. The proportionately large amount of follicle cell RNA apparently reflects the synthetic functions of these cells in the formation of yolk and the secretion of chorion. Of the 3 μg in the oocyte, only 1 μg is incorporated into the early embryo while the remainder is found in the yolk cells and serosa.
Autoradiography of follicles labeled with H3-uridine either in vivo or by a “pulsechase” procedure in vitro indicated that, as in other polytrophic insect ovaries, the nurse cell nuclei are the most conspicuous source of oocyte RNA. The germinal vesicle incorporated labeled uridine in previtellogenic follicles. In vitellogenic and later stages neither a germinal vesicle nor a follicle cell contribution to oocyte RNA was detected by the procedures used.
62 citations
TL;DR: The analysis of the relationship between classroom behavior and the achievement criteria indicates that when a child is underachieving, this is evident not only in the grade or test scores he receives but also in his broader functioning in the classroom.
Abstract: Using the Devereux Elementary School Behavior Rating Scale, a device developed to identify achievement related classroom behaviors in kindergarten through sixth grade, 298 ratings were made of chil...
59 citations
TL;DR: Optical rotatory power measurement for compensated cholesteric liquid crystal helical structure to observe thermally induced inversion and electric field perturbations was performed in this paper, where the authors measured the rotational power of the helical structures.
Abstract: Optical rotatory power measurement for compensated cholesteric liquid crystal helical structure to observe thermally induced inversion and electric field perturbations
TL;DR: A cluster of septal echoes of varying thickness impinging on the echoes of the anterior mitral leaflet during early diastole in 13 of 16 patients with idiopathic hypertrophic subaortic stenosis was the typical finding, and the pattern of decreased slope with normal configuration seen in some patients with aorti stenosis and in 3 with idio-hygiene hypertrophicSubaortics stenosis may indicate a lesser degree of interference.
Abstract: The echocardiographic findings in 16 patients with idiopathic hypertrophic subaortic stenosis are described and compared with those in 25 patients with valvular aortic stenosis. A cluster of septal echoes of varying thickness impinging on the echoes of the anterior mitral leaflet during early diastole in 13 of 16 patients with idiopathic hypertrophic subaortic stenosis was the typical finding. A similar finding was present in only 1 patient with valvular aortic stenosis. It is suggested that this pattern indicates interference with the normal anterior mitral leaflet motion by the severe septal hypertrophy during early diastole. The pattern of decreased slope with normal configuration seen in some patients with aortic stenosis (group C) and in 3 with idiopathic hypertrophic subaortic stenosis (group B) may indicate a lesser degree of interference. The decreased left ventricular compliance present in both conditions is probably an important underlying factor.
TL;DR: In this article, a number of crystalline metal perchlorate complexes with diisopropyl methylphosphonate (DIMP) were synthesized and found to be of the general type [M(dIMP 4 ]ClO 4 ) 2 for divalent metal ions.
TL;DR: Acemically related behaviors were described by teachers of regular and special class (emotionally disturbed) junior-senior high school students and the relevance of behavior to academic success or failure was interpreted.
Abstract: How can the educator be helped to focus upon achievement related classroom behavior in an organized, reliable, and communicable fashion? Academically related behaviors were described by teachers of...
TL;DR: In this article, a trivalent metal chlorides with diisopropyl methylphosphonate was shown to have polynuclear configurations, involving eight-membered phosphonate bridges and possibly four-memered chelate rings, with a distorted O h ligand-field symmetry.
TL;DR: Some closely related sterols have been separated with better resolution in a shorter period of time than has previously been reported.
Abstract: The valve-point loading logic described in this paper is intended to meet at any time in the most economical fashion a generation commitment. This objective is approached by insuring that as great a portion of the load as practicable will be carried by units loaded to valve points, that the remainder of the load will be carried by units reserved for regulation, and that in both categories the assignments will be made to those units which can provide the requisite capacity at the lowest cost.
TL;DR: In this paper, a theory based on flow across a selected control volume is developed to predict the Hugoniot of a shock moving along the longitudinal direction of a unidirectional fiber reinforced composite.
Abstract: : A theory based on flow across a selected control volume is developed to predict the Hugoniot of a shock moving along the longitudinal direction of a unidirectional fiber reinforced composite. From this theory the Hugoniot of a composite may be calculated from the equations of state of its constituents. The shear force along the matrix-fiber interface can also be computed. A sample calculation using polyethylene as matrix and beryllium as fiber has been made. The calculated shock Hugoniot is not far from linear. (Author)
TL;DR: Hendins et al. as mentioned in this paper used the relatively mild reducing agent sodium borohydride in SNP rate enhancing, polar, aprotic solvents to selectively displace halogens and other good leaving groups with hydrogen without affecting other reducible functional groups.
TL;DR: Dimethyl methylphosphonate (DMMP) cationic complexes with metal perchlorates of the types [M(DMMP 4 ] 2+ (M Ni, Cu), [M[DMMP 5 ] 2+, (Mg, Fe, Al, Cr, Cr), Mn(II), Fe(III), Al(III) have been prepared and characterized by means of spectral, magnetic conductance and in certain cases, X-ray powder diffraction studies as mentioned in this paper.
TL;DR: Some antitumor agents known to specifically inhibit certain tumor cell enzymes were examined for activity against glycolytic enzymes and growth of the insect trypanosomatid, Crithidia fasciculata, and all of the compounds used specifically inhibited cancer cell alpha-glycerophosphate dehydrogenase.
Abstract: Some antitumor agents known to specifically inhibit certain tumor cell enzymes were examined for activity against glycolytic enzymes and growth of the insect trypanosomatid, Crithidia fasciculata. The cytoplasmic enzymes hexokinase, α-glycerophosphate dehydrogenase, malic dehydrogenase, and glucose-6-phosphate dehydrogenase were tested. Agaricic acid (2-hydroxy-1,2,3-nonadecane tricarboxylic acid) was highly inhibitory (50 to 100%) to malic and α-glycerophosphate dehydrogenases at ∼3 × 10−5m; 2-(p-hydroxyphenyl)-2-phenylpropane (2 × 10−4m), and 5,6-dichloro-2-benzoxazolinone (5 × 10−4m) were less effective (50% inhibition) against them. The antiprotozoal agents primaquine (4 × 10−4m) and Melarsoprol (8 × 10−4m) were 30 to 40% inhibitory. Agaricic acid, 2-(p-hydroxyphenyl)-2-phenylpropane, and 5,6-dichloro-2-benzoxazolinone inhibited growth of Crithidia at less than 10−4m. Eight other test compounds from the Cancer Chemotherapy National Service Center (CCNSC) were not toxic to cell growth, although two (4-biphenylcarboxylic acid and 1-[p-chlorobenzyl]-2-ethyl-5-methyl-indole-3-acetic acid) inhibited Crithidia α-glycerophosphate dehydrogenase below 1 mm. All of the compounds used specifically inhibited cancer cell α-glycerophosphate dehydrogenase. The corresponding enzyme in pathogenic African trypanosomes is important in their terminal respiration. C. fasciculata may be useful in preliminary evaluation of chemotherapeutic agents as potential trypanocides.
TL;DR: In this paper, a detailed diseussion of the interpretation of a seattering process within the framework of relativistic quantum mechanics is presented, particularly suited to the seattering of charged scalar particles in an external electromagnetic field.
Abstract: We present a detailed diseussion of the interpretation of a seattering process within the framework of relativistic quantum mechanics. This argument is particularly well suited to the seattering of charged scalar particles in an external electromagnetic field, but it breaks down for spin-1/2 particles. In the latter case, we can improve certain features if we use the Klein-Gordon equation instead of the Dirae equation.
TL;DR: In this paper, the diamide, Yb(NH 2 ) 2, is the predominant decomposition product of liquid ammonia solutions of ytterbium metal, and the processes leading to formation of diamide and triamide are examined, and why the differences in both the decomposition of the metal solutions and the thermal decomposition products occur.
Abstract: At −50 °C, the diamide, Yb(NH 2 ) 2 , is the predominant decomposition product of liquid ammonia solutions of ytterbium metal. Europium metal solutions decompose to form the diamide exclusively at −50 °C. Thermal decomposition leads to the imide, EuNH, for europium, and the nitride, YbN, for ytterbium. The heats of solution of europium and ytterbium in liquid ammonia are calculated to be −20.9 and −19.4 kcal/g.-at., respectively. The processes leading to formation of the diamide and triamide are examined, and it is shown why the differences in both the decomposition of the metal solutions and the thermal decomposition products occur.
TL;DR: The technique of streak photography was modified to use seven parallel cameras, each focused on an individual root in a guide holding flowing nutrient, which resulted in heavily dampened oscillatory responses as well as reduction in growth rate.
Abstract: 1.
The technique of streak photography was modified to use seven parallel cameras, each focused on an individual root in a guide holding flowing nutrient. Streak photographs representing displacement of points on the longitudinal axis of the root were projected on the table of an image plane digitizer. The displacement data are collected on cards by an IBM 526 key punch and processed by an IBM 360-65 computer. All graphic data were plotted by an EAI line plotter having a resolution of 600 lines per inch.
2.
Roots of corn held at a temperature of 25°, a pH of 5.6, with constant oxygen concentration and basic nutrient composition, were subjected to step changes in oxygen and auxin (3-indoleacetic acid, IAA) concentrations. When O2 was lowered the response of the root consisted of a large reduction in growth rate followed by a series of oscillations with a period of about 30–50 min. Step changes in IAA from 0–10-8M (or less) resulted in heavily dampened oscillatory responses as well as reduction in growth rate. 10-7 M IAA, however, elicited the initial inhibition followed by full recovery of growth rate after a few hours.
TL;DR: In this paper, the authors measured the dark and photoconductivities of different types of cholesteric materials at phase transition points and found that the photo-response of the liquid crystal phase was only a very small photoresponse.
Abstract: Dark and photoconductivities of nematic, smectic and cholesteric materials have been measured with particular attention to the changes in properties at phase transitions. Although a reasonably large photo-response could be found in several liquid crystals at room temperature, only a very small photoresponse occurred in the liquid crystal state. At the transition point solid → liquid crystal the dark conductivity, [sgrave] D and the thermal activation energy, Ea typically show large changes, while in the liquid crystal → liquid transition, [sgrave] D and Ea change only slightly. Both transition temperatures can easily be identified in the plots of log [sgrave] vs I/T, and agree well with microscopic and calorimetric observations. Cholesteric materials show a surprising decrease in dark conductivity at the solid → cholesteric transition during heating, in contrast with the behavior of nematic and smectic materials.
TL;DR: Collagen fibrils have been identified by electron microscopy and hydroxyproline assay in synovial fluid sediments from patients with a variety of joint diseases but phase contrast and polarized light microscopy alone proved inadequate to distinguish these fibril from fibrin strands.
Abstract: Collagen fibrils have been identified by electron microscopy and hydroxyproline assay in synovial fluid sediments from patients with a variety of joint diseases. Phase contrast and polarized light microscopy alone proved inadequate to distinguish these fibrils from fibrin strands. The potential sources and significance of the presence of collagen fibrils in synovial fluid sediments are discussed.
TL;DR: Evidence is provided that the amino acid content of yeast cells and their free amino acid pools are markedly affected by biotin deficiency as well as by supplementation with aspartate, indicating that aspartates plays a major role in the nitrogen economy of yeast under both normal as wellAs abnormal nutritional conditions.
Abstract: Yeast cells grown under optimal and suboptimal concentrations of biotin were analyzed for the amino acid content of their soluble pool and cellular protein. Optimally grown yeast cells exhibited a maximum amino acid content after 18 hr of growth. Biotin-deficient cells were depleted of all amino acids at 26 and 43 hr, with alanine, arginine, aspartate, cysteine, glutamate, isoleucine, leucine, lysine, methionine, serine, threonine, and valine being present in less than half the concentration observed in biotin-optimal cells. At early time intervals, the amino acid pool of biotin-deficient yeast contained lower concentrations of all amino acids except alanine. After more prolonged incubation, several amino acids accumulated in the pool of biotin-deficient yeast, but citrulline and ornithine accumulated to appreciable levels. The addition of aspartate to the growth medium resulted in a decrease in the amino acid content of biotin-optimal cells but caused a marked increase in the concentration of amino acids in biotin-deficient cells. The pools of biotin-deficient yeast grown in the presence of aspartate displayed a marked reduction in every amino acid with the exception of aspartate itself. These data provide evidence that the amino acid content of yeast cells and their free amino acid pools are markedly affected by biotin deficiency as well as by supplementation with aspartate, indicating that aspartate plays a major role in the nitrogen economy of yeast under both normal as well as abnormal nutritional conditions.