Institution
Drug Abuse Resistance Education
About: Drug Abuse Resistance Education is a based out in . It is known for research contribution in the topics: Cancer & Population. The organization has 298 authors who have published 1883 publications receiving 83526 citations. The organization is also known as: Drug Abuse Resistance Education.
Topics: Cancer, Population, Breast cancer, Lung cancer, Radiation therapy
Papers published on a yearly basis
Papers
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TL;DR: The BIOMED-2 multiplex tubes can now be used for diagnostic clonality studies as well as for the identification of PCR targets suitable for the detection of minimal residual disease.
Abstract: In a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) and T-cell receptor (TCR) genes and the chromosome aberrations t(11;14) and t(14;18). This has resulted in 107 different primers in only 18 multiplex PCR tubes: three VH-JH, two DH-JH, two Ig kappa (IGK), one Ig lambda (IGL), three TCR beta (TCRB), two TCR gamma (TCRG), one TCR delta (TCRD), three BCL1-Ig heavy chain (IGH), and one BCL2-IGH. The PCR products of Ig/TCR genes can be analyzed for clonality assessment by heteroduplex analysis or GeneScanning. The detection rate of clonal rearrangements using the BIOMED-2 primer sets is unprecedentedly high. This is mainly based on the complementarity of the various BIOMED-2 tubes. In particular, combined application of IGH (VH-JH and DH-JH) and IGK tubes can detect virtually all clonal B-cell proliferations, even in B-cell malignancies with high levels of somatic mutations. The contribution of IGL gene rearrangements seems limited. Combined usage of the TCRB and TCRG tubes detects virtually all clonal T-cell populations, whereas the TCRD tube has added value in case of TCRgammadelta(+) T-cell proliferations. The BIOMED-2 multiplex tubes can now be used for diagnostic clonality studies as well as for the identification of PCR targets suitable for the detection of minimal residual disease.
2,902 citations
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TL;DR: MRI appears to be more sensitive than mammography in detecting tumors in women with an inherited susceptibility to breast cancer.
Abstract: background The value of regular surveillance for breast cancer in women with a genetic or familial predisposition to breast cancer is currently unproven. We compared the efficacy of magnetic resonance imaging (MRI) with that of mammography for screening in this group of high-risk women. methods Women who had a cumulative lifetime risk of breast cancer of 15 percent or more were screened every six months with a clinical breast examination and once a year by mammography and MRI, with independent readings. The characteristics of the cancers that were detected were compared with the characteristics of those in two different agematched control groups. results We screened 1909 eligible women, including 358 carriers of germ-line mutations. Within a median follow-up period of 2.9 years, 51 tumors (44 invasive cancers, 6 ductal carcinomas in situ, and 1 lymphoma) and 1 lobular carcinoma in situ were detected. The sensitivity of clinical breast examination, mammography, and MRI for detecting invasive breast cancer was 17.9 percent, 33.3 percent, and 79.5 percent, respectively, and the specificity was 98.1 percent, 95.0 percent, and 89.8 percent, respectively. The overall discriminating capacity of MRI was significantly better than that of mammography (P<0.05). The proportion of invasive tumors that were 10 mm or less in diameter was significantly greater in our surveillance group (43.2 percent) than in either control group (14.0 percent [P<0.001] and 12.5 percent [P = 0.04], respectively). The combined incidence of positive axillary nodes and micrometastases in invasive cancers in our study was 21.4 percent, as compared with 52.4 percent (P<0.001) and 56.4 percent (P=0.001) in the two control groups. conclusions MRI appears to be more sensitive than mammography in detecting tumors in women with an inherited susceptibility to breast cancer.
1,528 citations
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Katholieke Universiteit Leuven1, University of Toronto2, Charles University in Prague3, Maastricht University4, University of South Florida5, Lyon College6, University of Chicago7, Curie Institute8, Catholic University of the Sacred Heart9, University of São Paulo10, University of Liverpool11, University of Rochester12, Drug Abuse Resistance Education13
TL;DR: There is mounting data regarding the utility of GA in oncology practice; however, additional research is needed to continue to strengthen the evidence base.
Abstract: Purpose To update the International Society of Geriatric Oncology (SIOG) 2005 recommendations on geriatric assessment (GA) in older patients with cancer. Methods SIOG composed a panel with expertise in geriatric oncology to develop consensus statements after literature review of key evidence on the following topics: rationale for performing GA; findings from a GA performed in geriatric oncology patients; ability of GA to predict oncology treatment–related complications; association between GA findings and overall survival (OS); impact of GA findings on oncology treatment decisions; composition of a GA, including domains and tools; and methods for implementing GA in clinical care. Results GA can be valuable in oncology practice for following reasons: detection of impairment not identified in routine history or physical examination, ability to predict severe treatment-related toxicity, ability to predict OS in a variety of tumors and treatment settings, and ability to influence treatment choice and intensit...
1,266 citations
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TL;DR: It is shown that CQ mainly inhibits autophagy by impairing autophagosome fusion with lysosomes rather than by affecting the acidity and/or degradative activity of this organelle.
Abstract: Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradati...
1,178 citations
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TL;DR: Properties of the receptive fields of simple cells in macaque cortex were compared with properties of independent component filters generated by independent component analysis on a large set of natural images: there is no match, however, in calculated and measured distributions for the peak of the spatial frequency response.
Abstract: Properties of the receptive fields of simple cells in macaque cortex were compared with properties of independent component filters generated by independent component analysis (ICA) on a large set of natural images. Histograms of spatial frequency bandwidth, orientation tuning bandwidth, aspect ratio and length of the receptive fields match well. This indicates that simple cells are well tuned to the expected statistics of natural stimuli. There is no match, however, in calculated and measured distributions for the peak of the spatial frequency response: the filters produced by ICA do not vary their spatial scale as much as simple cells do, but are fixed to scales close to the finest ones allowed by the sampling lattice. Possible ways to resolve this discrepancy are discussed.
1,134 citations
Authors
Showing all 298 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rinaldo Bellomo | 147 | 1714 | 120052 |
Peter M. Lansdorp | 105 | 330 | 43982 |
Johannes A. Langendijk | 76 | 529 | 18786 |
Harry J.M. Groen | 74 | 450 | 24660 |
Ed Schuuring | 63 | 222 | 15173 |
Hanneke C. Kluin-Nelemans | 62 | 272 | 14350 |
Ali T. Taher | 57 | 595 | 13810 |
Thera P. Links | 57 | 309 | 11199 |
Jourik A. Gietema | 56 | 247 | 11394 |
Frank A.E. Kruyt | 50 | 137 | 8555 |
Jan C. Oosterwijk | 49 | 204 | 8780 |
Geertruida H. de Bock | 48 | 330 | 8297 |
Nico van Zandwijk | 48 | 176 | 8465 |
Dirk Sleijfer | 48 | 212 | 7349 |
Guang-Yu Guo | 48 | 323 | 9075 |