Institution
Dublin City University
Education•Dublin, Ireland•
About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Machine translation & Laser. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.
Topics: Machine translation, Laser, Irish, Population, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: The metabolism and immunological relevance of sialic acids are described and how their properties have been exploited by the pharmaceutical industry to enhance the therapeutic properties of proteins such as asparaginase and darbepoetin alpha are outlined.
138 citations
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TL;DR: Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, and one to eight arginine residues, (Ru-Ahx-R8); both complexes exhibit long-lived, intense, and oxygen-sensitive luminescence.
137 citations
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TL;DR: It is revealed that miR-29 acts as an important regulator of insulin-stimulated glucose metabolism and lipid oxidation, with relevance to human physiology and type 2 diabetes.
Abstract: MicroRNAs have emerged as important regulators of glucose and lipid metabolism in several tissues; however, their role in skeletal muscle remains poorly characterized. We determined the effects of the miR-29 family on glucose metabolism, lipid metabolism, and insulin responsiveness in skeletal muscle. We provide evidence that miR-29a and miR-29c are increased in skeletal muscle from patients with type 2 diabetes and are decreased following endurance training in healthy young men and in rats. In primary human skeletal muscle cells, inhibition and overexpression strategies demonstrate that miR-29a and miR-29c regulate glucose uptake and insulin-stimulated glucose metabolism. We identified that miR-29 overexpression attenuates insulin signaling and expression of insulin receptor substrate 1 and phosphoinositide 3-kinase. Moreover, miR-29 overexpression reduces hexokinase 2 expression and activity. Conversely, overexpression of miR-29 by electroporation of mouse tibialis anterior muscle decreased glucose uptake and glycogen content in vivo, concomitant with decreased abundance of GLUT4. We also provide evidence that fatty acid oxidation is negatively regulated by miR-29 overexpression, potentially through the regulation of peroxisome proliferator–activated receptor γ coactivator-1α expression. Collectively, we reveal that miR-29 acts as an important regulator of insulin-stimulated glucose metabolism and lipid oxidation, with relevance to human physiology and type 2 diabetes.
137 citations
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TL;DR: Rapid in-package HVACP inactivation of bacterial spores within 30-60s demonstrates the promising potential application for reduction of spores on medical devices and heat-sensitive materials.
137 citations
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TL;DR: A critical comparative evaluation of 5 miniaturised colorimetric assays applicable to cytotoxicity testing of anti-tumour drugs (and other toxins)in vitro found two of the more recently developed assays (APNaOH and SRB) were found to be very sensitive under the conditions examined.
Abstract: This paper describes a critical comparative evaluation of 5 miniaturised colorimetric assays applicable to cytotoxicity testing of anti-tumour drugs (and other toxins)in vitro. Each assay shows a different linear range for optical density versus cell number, a different sensitivity to change in cell number and a different minimum detectable cell number; the values of these parameters vary with experimental conditions and with cell line used. All the methods gave good correlation with viable cell number (determined by colony forming efficiency) in toxicity assays after 3 or 4 days of treatment, but they underestimated cell death after 2 days. Toxicity levels for individual chemicals (in a standard 6-day assay) are similar for the different assays, irrespective of the mechanism of action of the chemical being tested. Two of the more recently developed assays (APNaOH and SRB) were found to be very sensitive under the conditions examined.
137 citations
Authors
Showing all 6059 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joseph Wang | 158 | 1282 | 98799 |
David Cameron | 154 | 1586 | 126067 |
David Taylor | 131 | 2469 | 93220 |
Gordon G. Wallace | 114 | 1267 | 69095 |
David A. Morrow | 113 | 598 | 56776 |
G. Hughes | 103 | 957 | 46632 |
David Wilson | 102 | 757 | 49388 |
Muhammad Imran | 94 | 3053 | 51728 |
Haibo Zeng | 94 | 604 | 39226 |
David Lloyd | 90 | 1017 | 37691 |
Vikas Kumar | 89 | 859 | 39185 |
Luke P. Lee | 84 | 413 | 22803 |
James Chapman | 82 | 483 | 36468 |
Muhammad Iqbal | 77 | 961 | 23821 |
Michael C. Berndt | 76 | 228 | 16897 |