Dublin City University

About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Machine translation & Laser. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.

Development of a high sensitivity rapid sandwich ELISA procedure and its comparison with the conventional approach.

Abstract: A highly sensitive and rapid sandwich enzyme-linked immunosorbent assay (ELISA) procedure was developed for the detection of human fetuin A/AHSG (α2-HS-glycoprotein), a specific biomarker for hepatocellular carcinoma and atherosclerosis. Anti-human fetuin A antibody was immobilized on aminopropyltriethoxysilane-mediated amine-functionalized microtiter plates using 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride and N-hydroxysulfosuccinimide-based heterobifunctional cross-linking. The analytical sensitivity of the developed assay was 39 pg/mL, compared to 625 pg/mL for the conventional assay. The generic nature of the developed procedure was demonstrated by performing human fetuin A assays on different polymeric matrixes, i.e., polystyrene, poly(methyl methacrylate), and polycyclo-olefin (Zeonex), in a modified microtiter plate format. Thus, the newly developed procedure has considerable advantages over the existing method.

Residual stress in HVOF thermally sprayed thick deposits

Abstract: Due to the nature of the high velocity oxy-fuel thermal spray process, residual stress build up in thick deposits is a significant and a limiting problem. The residual stress-state that evolves in a deposit is largely dependent on the thermal conditions to which the system has been subjected, and is a combination of quenching stresses, which arise during deposition, and cooling stresses, post-deposition. It follows that precise control of these phenomena is essential, if a thick deposit is to be thermally sprayed. This paper applies an analytical technique to calculate residual stress in thermally sprayed deposits based on geometric properties. Residual stress results for WC–Co (tungsten carbide–cobalt) samples are compared to experimental results (X-ray diffraction and hole-drilling method). A change in deposit stress-state from tensile to compressive stress with deposit thickness is analysed in terms of quenching and cooling stresses.

Managing evolution and change in web-based teaching and learning environments

Abstract: The state of the art in information technology and educational technologies is evolving constantly. Courses taught are subject to constant change from organisational and subject-specific reasons. Evolution and change affect educators and developers of computer-based teaching and learning environments alike both often being unprepared to respond effectively. Educational systems are often designed and developed without change and evolution in mind. We will present our approach to the design and maintenance of these systems in rapidly evolving environments and illustrate the consequences of evolution and change for these systems and for the educators and developers responsible for their implementation and deployment. We discuss various factors of change, illustrated by a Web-based virtual course, with the objective of raising an awareness of this issue of evolution and change in computer-supported teaching and learning environments. This discussion leads towards the establishment of a development and management framework for teaching and learning systems.