Dublin City University

About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Context (language use) & Machine translation. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.

A Container-Based Edge Cloud PaaS Architecture Based on Raspberry Pi Clusters

Abstract: Cloud technology is moving towards multi-cloud environments with the inclusion of various devices. Cloud and IoT integration resulting in so-called edge cloud and fog computing has started. This requires the combination of data centre technologies with much more constrained devices, but still using virtualised solutions to deal with scalability, flexibility and multi-tenancy concerns. Lightweight virtualisation solutions do exist for this architectural setting with smaller, but still virtualised devices to provide application and platform technology as services. Containerisation is a solution component for lightweight virtualisation solution. Containers are furthermore relevant for cloud platform concerns dealt with by Platform-as-a-Service (PaaS) clouds like application packaging and orchestration. We demonstrate an architecture for edge cloud PaaS. For edge clouds, application and service orchestration can help to manage and orchestrate applications through containers. In this way, computation can be brought to the edge of the cloud, rather than data from the Internet-of-Things (IoT) to the cloud. We show that edge cloud requirements such as cost-efficiency, low power consumption, and robustness can be met by implementing container and cluster technology on small single-board devices like Raspberry Pis. This architecture can facilitate applications through distributed multi-cloud platforms built from a range of nodes from data centres to small devices, which we refer to as edge cloud. We illustrate key concepts of an edge cloud PaaS and refer to experimental and conceptual work to make that case.

Osteogenic cell response to 3-D hydroxyapatite scaffolds developed via replication of natural marine sponges

Abstract: Bone tissue engineering may provide an alternative to autograft, however scaffold optimisation is required to maximize bone ingrowth. In designing scaffolds, pore architecture is important and there is evidence that cells prefer a degree of non-uniformity. The aim of this study was to compare scaffolds derived from a natural porous marine sponge (Spongia agaricina) with unique architecture to those derived from a synthetic polyurethane foam. Hydroxyapatite scaffolds of 1 cm3 were prepared via ceramic infiltration of a marine sponge and a polyurethane (PU) foam. Human foetal osteoblasts (hFOB) were seeded at 1 × 105 cells/scaffold for up to 14 days. Cytotoxicity, cell number, morphology and differentiation were investigated. PU-derived scaffolds had 84–91 % porosity and 99.99 % pore interconnectivity. In comparison marine sponge-derived scaffolds had 56–61 % porosity and 99.9 % pore interconnectivity. hFOB studies showed that a greater number of cells were found on marine sponge-derived scaffolds at than on the PU scaffold but there was no significant difference in cell differentiation. X-ray diffraction and inductively coupled plasma mass spectrometry showed that Si ions were released from the marine-derived scaffold. In summary, three dimensional porous constructs have been manufactured that support cell attachment, proliferation and differentiation but significantly more cells were seen on marine-derived scaffolds. This could be due both to the chemistry and pore architecture of the scaffolds with an additional biological stimulus from presence of Si ions. Further in vivo tests in orthotopic models are required but this marine-derived scaffold shows promise for applications in bone tissue engineering.

Calixarenes: designer ligands for chemical sensors.

Abstract: These cup-shaped molecules can form inclusion complexes with a wide range of guest species.

Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications

Abstract: The capability of 3D printing technologies for direct production of complex 3D structures in a single step has recently attracted an ever increasing interest within the field of microfluidics. Recently, ultrafast lasers have also allowed developing new methods for production of internal microfluidic channels within the bulk of glass and polymer materials by direct internal 3D laser writing. This review critically summarizes the latest advances in the production of microfluidic 3D structures by using 3D printing technologies and direct internal 3D laser writing fabrication methods. Current applications of these rapid prototyped microfluidic platforms in biology will be also discussed. These include imaging of cells and living organisms, electrochemical detection of viruses and neurotransmitters, and studies in drug transport and induced-release of adenosine triphosphate from erythrocytes.