Institution
Dublin City University
Education•Dublin, Ireland•
About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Machine translation & Laser. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.
Topics: Machine translation, Laser, Irish, Population, Context (language use)
Papers published on a yearly basis
Papers
More filters
TL;DR: Nurses’ and physicians’ perceptions of what actually happens when an aggressive behaviour episode occurs on the ward and what alternatives to seclusion and restraint are actually in use as normal standard practice in acute psychiatric care are explored.
Abstract: The use of patient restrictions (e.g. involuntary admission, seclusion, restraint) is a complex ethical dilemma in psychiatric care. The present study explored nurses' (n = 22) and physicians' (n = 5) perceptions of what actually happens when an aggressive behaviour episode occurs on the ward and what alternatives to seclusion and restraint are actually in use as normal standard practice in acute psychiatric care. The data were collected by focus group interviews and analysed by inductive content analysis. The participants believed that the decision-making process for managing patients' aggressive behaviour contains some in-built ethical dilemmas. They thought that patients' subjective perspective received little attention. Nevertheless, the staff proposed and appeared to use a number of alternatives to minimize or replace the use of seclusion and restraint. Medical and nursing staff need to be encouraged and taught to: (1) tune in more deeply to reasons for patients' aggressive behaviour; and (2) use alternatives to seclusion and restraint in order to humanize patient care to a greater extent.
102 citations
TL;DR: This is the first report demonstrating a functional impact of specific miRNA disregulation on CHO cell behavior in batch culture and provides some evidence of the potential which these molecules may have in terms of engineering targets in CHO production clones.
102 citations
TL;DR: A mixed microbial community, specially designed todegrade a wide range of substituted aromatic compounds, was examined for its ability to degrademono-chlorophenols as sole carbon source in aerobicbatch cultures, indicating complete degradation of 4- chlorophenol by the mixed culture via ameta- cleavage pathway.
Abstract: A mixed microbial community, specially designed todegrade a wide range of substituted aromaticcompounds, was examined for its ability to degrademono-chlorophenols as sole carbon source in aerobicbatch cultures. The mixed culture degraded 2-, 3-, and4 -chlorophenol (1.56 mM) via a meta- cleavagepathway. During the degradation of 2- and3-chlorophenol by the mixed culture, 3-chlorocatecholproduction was observed. Further metabolism was toxicto cells as it led to inactivation of the catechol2,3-dioxygenase enzyme upon meta- cleavage of3-chlorocatechol resulting in incomplete degradation.Inactivation of the meta- cleavage enzyme led toan accumulation of brown coloured polymers, whichinterfered with the measurement of cell growth usingoptical denstiy. Degradation of 4-chlorophenol by themixed culture led to an accumulation of5-chloro-2-hydroxymuconic semialdehyde, themeta- cleavage product of 4-chlorocatechol. Theaccumulation of this compound did not interfere withthe measurement of cell growth using optical density.5-chloro-2-hydroxymuconic semialdehyde was furthermetabolized by the mixed culture with a stoichiometricrelease of chloride, indicating complete degradationof 4-chlorophenol by the mixed culture via ameta- cleavage pathway.
102 citations
14 Apr 2010
TL;DR: In this paper, a simple protocol for secure delegation of the elliptic-curve pairing is described, where a computationally limited device (typically a smart-card) will delegate the computation of the pairing e(A,B) to a more powerful device (for example a PC), in such a way that the powerful device learns nothing about the points A and B, and can detect when the limited device is cheating.
Abstract: In this paper we describe a simple protocol for secure delegation of the elliptic-curve pairing. A computationally limited device (typically a smart-card) will delegate the computation of the pairing e(A,B) to a more powerful device (for example a PC), in such a way that 1) the powerful device learns nothing about the points A and B, and 2) the limited device is able to detect when the powerful device is cheating.
102 citations
National Institutes of Health1, University of Utah2, University of California, Berkeley3, University of Alabama at Birmingham4, Memorial Sloan Kettering Cancer Center5, University of Texas MD Anderson Cancer Center6, University of Freiburg7, Harvard University8, Imperial College London9, Karolinska Institutet10, Paris Descartes University11, Sorbonne12, University of Southern California13, University of Sheffield14, City of Hope National Medical Center15, American Cancer Society16, Universidade Federal de Minas Gerais17, University of British Columbia18, Simon Fraser University19, University of New South Wales20, University of Cagliari21, Yale University22, University of Melbourne23, Cancer Council Victoria24, New York University25, Westat26, Mayo Clinic27, Statens Serum Institut28, Stanford University29, Uppsala University30, Exponent31, Veterans Health Administration32, University of Iowa33, University of California, San Francisco34, Ohio State University35, Fred Hutchinson Cancer Research Center36, University of Barcelona37, German Cancer Research Center38, Icahn School of Medicine at Mount Sinai39, International Agency for Research on Cancer40, University of Burgundy41, Dublin City University42, Duke University43, Drexel University44, Wayne State University45, Utrecht University46, University of Oxford47, National Institute for Health and Welfare48, University of Sydney49, Macquarie University50, University of Bari51, Dalian Maritime University52, University of York53, Dongguk University54, University of North Carolina at Chapel Hill55
TL;DR: Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
Abstract: Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
102 citations
Authors
Showing all 6059 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Joseph Wang | 158 | 1282 | 98799 |
| David Cameron | 154 | 1586 | 126067 |
| David Taylor | 131 | 2469 | 93220 |
| Gordon G. Wallace | 114 | 1267 | 69095 |
| David A. Morrow | 113 | 598 | 56776 |
| G. Hughes | 103 | 957 | 46632 |
| David Wilson | 102 | 757 | 49388 |
| Muhammad Imran | 94 | 3053 | 51728 |
| Haibo Zeng | 94 | 604 | 39226 |
| David Lloyd | 90 | 1017 | 37691 |
| Vikas Kumar | 89 | 859 | 39185 |
| Luke P. Lee | 84 | 413 | 22803 |
| James Chapman | 82 | 483 | 36468 |
| Muhammad Iqbal | 77 | 961 | 23821 |
| Michael C. Berndt | 76 | 228 | 16897 |