Dublin City University

About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Context (language use) & Machine translation. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.

The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity.

Abstract: The developing central nervous system and the blood brain barrier are especially vulnerable and sensitive to different chemicals, including environmental contaminants and drugs. Developmental exposure to these compounds has been involved in several neurological disorders, such as autism spectrum disorders as well as Alzheimer's and Parkinson's diseases. Zebrafish (Danio Rerio) have emerged as powerful toxicological model systems that can speed up chemical hazard assessment and can be used to extrapolate neurotoxic effects that chemicals have on humans. Zebrafish embryos and larvae are convenient for high-throughput screening of chemicals, due to their small size, low-cost, easy husbandry, and transparency. Additionally, zebrafish are homologous to other higher order vertebrates in terms of molecular signaling processes, genetic compositions, and tissue/organ structures as well as neurodevelopment. This mini review underlines the potential of the zebrafish as complementary models for developmental neurotoxicity screening of chemicals and describes the different endpoints utilized for such screening with some studies illustrating their use.

An evolutionary model for pulsar-driven supernova remnants. A hydrodynamical model

Abstract: We present a model of a pulsar wind nebula evolving inside its associated supernova remnant. The model uses a hydrodynamics code to simulate the evolution of this system when the pulsar has a high velocity. The simulation distinguishes four different stages of pulsar wind nebula evolution: the supersonic expansion stage, the reverse shock interaction stage, the subsonic expansion stage and ultimately the bow shock stage. The simulation bears out that, due to the high velocity of the pulsar, the position of the pulsar is off-centered with respect to its pulsar wind nebula, after the passage of the reverse shock. Subsequently the pulsar wind nebula expands subsonically until the event of the bow shock formation, when the motion of the pulsar becomes supersonic. The bow shock formation event occurs at roughly half the crossing time, when the pulsar is positioned at 0.677 times the radius of the supernova remnant blastwave, in complete agreement with analytical predictions. The crossing time is defined by the age of the supernova remnant when the pulsar overtakes the blastwave bounding the supernova remnant. The results of the model are applied to three supernova remnants: N157B, G327.1-1.1 and W44. We argue that the head of the pulsar wind nebula, containing the active pulsar, inside the first two systems is not bounded by a bow shock. However, in the case of W44 we argue for a scenario in which the pulsar wind nebula is bounded by a bow shock, due to the supersonic motion of the pulsar.