Institution
Dublin City University
Education•Dublin, Ireland•
About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Machine translation & Laser. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.
Topics: Machine translation, Laser, Irish, Population, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: Home-based NMES is an acceptable alternative to exercise therapy in the management of knee OA, producing similar improvements in functional capacity.
Abstract: Quadriceps femoris muscle (QFM) weakness is a feature of knee osteoarthritis (OA) and exercise programs that strengthen this muscle group can improve function, disability and pain. Traditional supervised resistance exercise is however resource intensive and dependent on good adherence which can be challenging to achieve in patients with significant knee OA. Because of the limitations of traditional exercise programs, interest has been shown in the use of neuromuscular electrical stimulation (NMES) to strengthen the QFM. We conducted a single-blind, prospective randomized controlled study to compare the effects of home-based resistance training (RT) and NMES on patients with moderate to severe knee OA. 41 patients aged 55 to 75 years were randomised to 6 week programs of RT, NMES or a control group receiving standard care. The primary outcome was functional capacity measured using a walk test, stair climb test and chair rise test. Additional outcomes were self-reported disability, quadriceps strength and cross-sectional area. Outcomes were assessed pre- and post-intervention and at 6 weeks post-intervention (weeks 1, 8 and 14 respectively). There were similar, significant improvements in functional capacity for the RT and NMES groups at week 8 compared to week 1 (p≤0.001) and compared to the control group (p < 0.005), and the improvements were maintained at week 14 (p≤0.001). Cross sectional area of the QFM increased in both training groups (NMES: +5.4%; RT: +4.3%; p = 0.404). Adherence was 91% and 83% in the NMES and RT groups respectively (p = 0.324). Home-based NMES is an acceptable alternative to exercise therapy in the management of knee OA, producing similar improvements in functional capacity. Trial registration: Current Controlled Trials ISRCTN85231954
95 citations
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TL;DR: Recombinant CL1, generated by functional expression of the cDNA in Saccharomyces cerevisiae, is used in this immunodiagnostic test and shows excellent potential for the development of the first standardized assay for the sensitive and specific diagnosis of human fascioliasis.
Abstract: Our laboratory recently developed a diagnostic test (ELISA) for human fascioliasis based on the detection of serum IgG4 antibodies reactive with Fasciola hepatica cathepsin L1 (CL1). In the present study, we have used recombinant CL1, generated by functional expression of the cDNA in Saccharomyces cerevisiae, in this immunodiagnostic test and compared its performance with native CL1. Sera obtained from 64 individuals living in Cutusuma village in the northern Altiplano of Bolivia, a region with a high prevalence of human fascioliasis, were analyzed by the IgG4-ELISA. A highly statistically significant correlation (r2 = 0.751, P < 0.001) was demonstrated between the absorbances obtained using the recombinant and native proteins. These assays showed that 38 (59%) of the individuals tested were seropositive for fascioliasis, whereas only 26 of them were coprologically positive for F. hepatica eggs. All seronegative patients were also coprologically negative. Serum from individuals infected with schistosomiasis mansoni, cysticercosis, hydatidosis, and Chagas disease did not contain antibodies reactive with the recombinant or native CL1. Therefore, recombinant CL1 shows excellent potential for the development of the first standardized assay for the sensitive and specific diagnosis of human fascioliasis. Finally, our data supports earlier reports on the high prevalence of human fascioliasis in the Bolivian Altiplano, which collectively suggest that the disease has been endemic there for more than a decade.
95 citations
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TL;DR: The rational design, generation and testing of a molecularly imprinted polymer specific for Ibuprofen and the characterisation of the MIP has been used to further enhance the understanding of the nature of MIP recognition.
95 citations
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TL;DR: In this article, the authors investigated the impact of clan controls at audit trainee levels in Big Four audit firms and found that the influence of partners' experience and intuition over a wide range of organisational activities, informal communication and signalling both within the partnership and between partners and staff, and the management of internal and external relationships.
95 citations
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TL;DR: In this article, the authors employ three-dimensional hydrodynamic simulations of a range of dense supersonic molecular jets, including various degrees of velocity pulsation and precession, to demonstrate how the observed structure depends on the band.
Abstract: The bandpasses for Spitzer images contain numerous molecular hydrogen emission lines. With the additional complication of the non-uniform spectral response, it is necessary to calculate model images in order to analyse observations of molecular outflows. We employ three-dimensional hydrodynamic simulations of a range of dense supersonic molecular jets, including various degrees of velocity pulsation and precession, to demonstrate how the observed structure depends on the band. Features in band 1, which is dominated by emission from vibrational levels, are even more concentrated than in K-band images. In contrast, bands 2-4 are dominated by rotational lines and bow shock wings appear extended. Especially in band 4, broken cavity walls can be detectable. An initial comparison with Spitzer data is made.
95 citations
Authors
Showing all 6059 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joseph Wang | 158 | 1282 | 98799 |
David Cameron | 154 | 1586 | 126067 |
David Taylor | 131 | 2469 | 93220 |
Gordon G. Wallace | 114 | 1267 | 69095 |
David A. Morrow | 113 | 598 | 56776 |
G. Hughes | 103 | 957 | 46632 |
David Wilson | 102 | 757 | 49388 |
Muhammad Imran | 94 | 3053 | 51728 |
Haibo Zeng | 94 | 604 | 39226 |
David Lloyd | 90 | 1017 | 37691 |
Vikas Kumar | 89 | 859 | 39185 |
Luke P. Lee | 84 | 413 | 22803 |
James Chapman | 82 | 483 | 36468 |
Muhammad Iqbal | 77 | 961 | 23821 |
Michael C. Berndt | 76 | 228 | 16897 |