Dublin City University

About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Machine translation & Laser. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.

Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer

Abstract: The Benzopyrones are a group of compounds whose members include coumarins and flavonoids. Dietary exposure to benzopyrones is quite significant, as these compounds are found in vegetables, fruit, seeds, nuts, coffee, tea and wine. It is estimated that the average western diet contains approximately 1 g/day of mixed benzopyrones. It is, therefore, not difficult to see why extensive research into their pharmacological and therapeutic properties is underway over many years. Coumarin is a natural substance that has shown anti-tumour activity in vivo, with the effect believed to be due to its metabolites (e.g. 7-hydroxycoumarin). This review is based on recent studies of coumarins and coumarin related compounds. Therefore, the focus will be on these relevant compounds and their therapeutic importance. A recent study has shown that 7-hydroxycoumarin inhibits the release of Cyclin D1, which is overexpressed in many types of cancer. This knowledge may lead to its use in cancer therapy. Esculetin inhibits growth and cell cycle progression by inducing arrest of the G(1) phase in HL-60 leukaemia cells, resulting from the inhibition of retinoblastoma protein phosphorylation. Recent studies investigating the potential of flavonoids as therapeutic agents have suggested they may have use in various therapeutic settings ranging from leukaemia treatment to the treatment of patients with HIV. Genistein is a well-known isoflavone and is a tyrosine kinase inhibitor. Studies have indicated that genistein elicits inhibitory effects on cell growth of various carcinoma cell-lines and may be a potential candidate for cancer therapy. In our research, we have investigated the effects of coumarins and coumarin-related compounds on a panel of cell-lines. The most recent work involves two cell-lines, MCF-7 a breast carcinoma and A549 a lung carcinoma. Microtitre assays were performed along with real-time analysis of cell viability using a biosensor called the Cytosensor microphysiometer. These studies suggest that both genistein and esculetin exerted the most potent inhibitory effect on cell growth in comparison to the other two compounds.

A Taxonomy of Pairing-Friendly Elliptic Curves

Abstract: Elliptic curves with small embedding degree and large prime-order subgroup are key ingredients for implementing pairing-based cryptographic systems. Such “pairing-friendly” curves are rare and thus require specific constructions. In this paper we give a single coherent framework that encompasses all of the constructions of pairing-friendly elliptic curves currently existing in the literature. We also include new constructions of pairing-friendly curves that improve on the previously known constructions for certain embedding degrees. Finally, for all embedding degrees up to 50, we provide recommendations as to which pairing-friendly curves to choose to best satisfy a variety of performance and security requirements.

Efficient and provably-secure identity-based signatures and signcryption from bilinear maps

Abstract: In this paper we describe a new identity-based signcryption (IBSC) scheme built upon bilinear maps. This scheme turns out to be more efficient than all others proposed so far. We prove its security in a formal model under recently studied computational assumptions and in the random oracle model. As a result of independent interest, we propose a new provably secure identity-based signature (IBS) scheme that is also faster than all known pairing-based IBS methods.