Institution
Dublin City University
Education•Dublin, Ireland•
About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Machine translation & Laser. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.
Topics: Machine translation, Laser, Irish, Population, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: Findings support the claim that the TAPES can be used to evaluate QOL for this patient group and further research is warranted to learn how sensitive the scale and its items are to change in clinical status.
163 citations
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03 Sep 2008TL;DR: An ISO/IEC JTC1/SC7 Working Group has been established to address the difficulties of very small development organizations by producing a software engineering standard tailored to VSE.
Abstract: Industry recognizes that very small enterprises (VSE), that develop parts involving software components are very important to the economy. These parts are often integrated into products of larger enterprises. Failure to deliver a quality product on time and within budget threatens the competitiveness of both organizations. One way to mitigate these risks is to haveall suppliers of a product chain put recognized engineering practices in place. Many international standards and models such as ISO/IEC12207 or CMMI have been developed to capture proven engineering practices. However, these standards were not designed for very small development organizations, those with less than 25 employees, and are consequently difficult to apply in such settings. An ISO/IEC JTC1/SC7 Working Group has been established to address these difficulties by producing a software engineering standard tailored to VSE.
163 citations
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TL;DR: Serum from women with breast cancer undergoing surgical excision who were randomized to receive a PPA anaesthetic technique led to greater human donor NK cell cytotoxicity in vitro compared with serum from women who received GA.
Abstract: Background Animal models and retrospective clinical data suggest that certain anaesthetic techniques can attenuate immunosuppression and minimize metastasis after cancer surgery. Natural killer (NK) T cells are a critical component of the anti-tumour immune response. We investigated the effect of serum from women undergoing primary breast cancer surgery, randomized to propofol–paravertebral block (PPA) or sevoflurane–opioid (GA) anaesthetic techniques, on healthy human donor NK cell function and cytotoxicity against oestrogen and progesterone receptor-positive breast cancer cells (HCC1500). Methods Ten subjects who donated serum before operation and 24 h after operation in an ongoing randomized prospective trial (NCT 00418457) were randomly selected. Serum from PPA ( n =5) and GA ( n =5) subjects was co-cultured with HCC1500 and healthy primary NK cells. NK cell activating receptors (NKp30, NKp44, NKp46, 2b4, CD16, NKG2D), cytokine production, NK CD107a expression, and cytotoxicity towards HCC1500 were examined. Results Serum from PPA subjects did not alter normal NK marker expression or secretion of cytokines. Serum from GA subjects reduced NK cell activating receptor CD16 [from mean (sem), 82 (2)% to 50 (4)%, P =0.001], IL-10 [from 1700 (80) to 1200 (92) pg ml −1 , P =0.001], and IL-1β [from 68 (12) to 19 (4) pg ml −1 , P =0.01]. An increase in NK cell CD107a [23 (2)% to 37(3)%, P =0.007] and apoptosis of HCC1500 [11 (1)% to 21 (2)%, P =0.0001] was observed with PPA serum, but not GA serum, treated NK cells. Conclusion Serum from women with breast cancer undergoing surgical excision who were randomized to receive a PPA anaesthetic technique led to greater human donor NK cell cytotoxicity in vitro compared with serum from women who received GA. Clinical trial registration NCT 041857.
163 citations
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TL;DR: This article found that the frequency of auditors' dysfunctional behaviour increased sharply as budgets were seen to approach unattainable levels of performance, and examined antecedent variables affecting budget attainability, such as client fee expectations, the level of audit senior participation and the influence of the audit program.
Abstract: Research suggests that dysfunctional behaviour by auditors may be related to the perceived tightness of time budgets. Using data collected from practising auditors, examines the nature of such a relationship. Found that the frequency of dysfunctional behaviour increased sharply as budgets were seen to approach unattainable levels of performance. Recognizing the importance of auditors’ perceptions regarding the attainability of budgets, examines antecedent variables affecting budget attainability. Found that the influence of client fee expectations, the level of audit senior participation and the influence of the audit programme were significant influences. Discusses implications for practice and possibilities for future research.
163 citations
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TL;DR: An accessible account of molecular methods to probe inorganic–nucleic acid interactions using copper(II) and platinum(ii) complexes prepared in the authors' laboratories is provided.
Abstract: The binding of small molecule metallodrugs to discrete regions of nucleic acids is an important branch of medicinal chemistry and the nature of these interactions, allied with sequence selectivity, forms part of the backbone of modern medicinal inorganic chemistry research. In this tutorial review we describe a range of molecular methods currently employed within our laboratories to explore novel metallodrug-DNA interactions. At the outset, an introduction to DNA from a structural perspective is provided along with descriptions of non-covalent DNA recognition focusing on intercalation, insertion, and phosphate binding. Molecular methods, described from a non-expert perspective, to identify non-covalent and pre-associative nucleic acid recognition are then demonstrated using a variety of techniques including direct (non-optical) and indirect (optical) methods. Direct methods include: X-ray crystallography; NMR spectroscopy; mass spectrometry; and viscosity while indirect approaches detail: competitive inhibition experiments; fluorescence and absorbance spectroscopy; circular dichroism; and electrophoresis-based techniques. For each method described we provide an overview of the technique, a detailed examination of results obtained and relevant follow-on of advanced biophysical/analytical techniques. To achieve this, a selection of relevant copper(ii) and platinum(ii) complexes developed within our laboratories are discussed and are compared, where possible, to classical DNA binding agents. Applying these molecular methods enables us to determine structure-activity factors important to rational metallodrug design. In many cases, combinations of molecular methods are required to comprehensively elucidate new metallodrug-DNA interactions and, from a drug discovery perspective, coupling this data with cellular responses helps to inform understanding of how metallodrug-DNA binding interactions manifest cytotoxic action.
162 citations
Authors
Showing all 6059 results
Name | H-index | Papers | Citations |
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Joseph Wang | 158 | 1282 | 98799 |
David Cameron | 154 | 1586 | 126067 |
David Taylor | 131 | 2469 | 93220 |
Gordon G. Wallace | 114 | 1267 | 69095 |
David A. Morrow | 113 | 598 | 56776 |
G. Hughes | 103 | 957 | 46632 |
David Wilson | 102 | 757 | 49388 |
Muhammad Imran | 94 | 3053 | 51728 |
Haibo Zeng | 94 | 604 | 39226 |
David Lloyd | 90 | 1017 | 37691 |
Vikas Kumar | 89 | 859 | 39185 |
Luke P. Lee | 84 | 413 | 22803 |
James Chapman | 82 | 483 | 36468 |
Muhammad Iqbal | 77 | 961 | 23821 |
Michael C. Berndt | 76 | 228 | 16897 |