École normale supérieure de Cachan

About: École normale supérieure de Cachan is a education organization based out in Cachan, Île-de-France, France. It is known for research contribution in the topics: Decidability & Finite element method. The organization has 2717 authors who have published 5585 publications receiving 175925 citations.

The increasing roles of epigenetics in breast cancer: Implications for pathogenicity, biomarkers, prevention and treatment.

Abstract: Nowadays, the mechanisms governing the occurrence of cancer are thought to be the consequence not only of genetic defects but also of epigenetic modifications. Therefore, epigenetic has become a very attractive and increasingly investigated field of research in order to find new ways of prevention and treatment of neoplasia, and this is particularly the case for breast cancer (BC). Thus, this review will first develop the main known epigenetic modifications that can occur in cancer and then expose the future role that control of epigenetic modifications might play in prevention, prognostication, follow-up and treatment of BC. Indeed, epigenetic biomarkers found in peripheral blood might become new tools to detect BC, to define its prognostic and to predict its outcome, whereas epi-drugs might have an increasing potential of development in the next future. However, if DNA methyltransferase inhibitors and histone desacetylase inhibitors have shown encouraging results in BC, their action remains nonspecific. Thus, additional clinical studies are needed to evaluate more precisely the effects of these molecules, even if they have provided encouraging results in cotreatment and combined therapies. This review will also deal with the potential of RNA interference (RNAi) as epi-drugs. Finally, we will focus on the potential prevention of BC through epigenetic based on diet and we will particularly develop the possible place of isothiocyanates from cruciferous vegetables or of Genistein from soybean in a dietary program that might potentially reduce the risk of BC in large populations.

Water-Waves as a Spatial Dynamical System

Abstract: The mathematical study of travelling waves, in the context of two-dimensional potential flows in one or several layers of perfect fluid(s) and in the presence of free surface and interfaces, can be formulated as an ill-posed evolution problem, where the horizontal space variable plays the role of “time”. In the finite depth case, the study of near equilibria waves reduces to a low-dimensional reversible ordinary differential equation. In most cases, it appears that the problem is a perturbation of an integrable system, where all types of solutions are known. We describe the method of study and review typical results. In addition, we study the infinite depth limit, which is indeed a case of physical interest. In such a case, the above reduction technique fails because the linearized operator possesses an essential spectrum filling the whole real axis, and new adapted tools are necessary. We also discuss the latest results on the existence of travelling waves in stratified fluids and on three-dimensional travelling waves, in the same spirit of reversible dynamical systems. Finally, we review the recent results on the classical two-dimensional standing wave problem.

Dipolar donor-acceptor-substituted schiff base complexes with large off-diagonal second-order nonlinear optical tensor components.

Abstract: The synthesis, characterization, and two-dimensional second-order nonlinear optical (NLO) response of a dipolar NiII donor- acceptor Schiff base complex and the related ligand are reported. Electric-field-induced second-harmonic generation and harmonic light (hyper-Rayleigh) scattering techniques, in combination with INDO/SCI-SOS theoretical calculations, were used to investigate the vector part of the hyperpolarizability tensor and the two-dimensional character of the molecular nonlinearity, respectively. Off-diagonal hyperpolarizability tensors can be related to charge-transfer transitions that are polarized perpendicular to the molecular dipolar axis, while parallel transitions account for the diagonal hyperpolarizability tensor. The role of the metal center in enhancing the two-dimensional NLO response of such molecules is twofold since it acts both as the donor and the bridging moiety of the planar donor-(pi-conjugate-bridge)-acceptor system. These dipolar two-dimensional molecules are interesting candidates from the perspective of polarization-independent NLO materials.

A rule-based language for web data management

Abstract: There is a new trend to use Datalog-style rule-based languages to specify modern distributed applications, notably on the Web. We introduce here such a language for a distributed data model where peers exchange messages (i.e. logical facts) as well as rules. The model is formally defined and its interest for distributed data management is illustrated through a variety of examples. A contribution of our work is a study of the impact on expressiveness of "delegations" (the installation of rules by a peer in some other peer) and explicit timestamps. We also validate the semantics of our model by showing that under certain natural conditions, our semantics converges to the same semantics as the centralized system with the same rules. Indeed, we show this is even true when updates are considered.