École normale supérieure de Cachan

About: École normale supérieure de Cachan is a education organization based out in Cachan, Île-de-France, France. It is known for research contribution in the topics: Decidability & Finite element method. The organization has 2717 authors who have published 5585 publications receiving 175925 citations.

Toward Early-warning Detection of Gravitational Waves from Compact Binary Coalescence

Abstract: Rapid detection of compact binary coalescence (CBC) with a network of advanced gravitational-wave detectors will offer a unique opportunity for multi-messenger astronomy. Prompt detection alerts for the astronomical community might make it possible to observe the onset of electromagnetic emission from CBC. We demonstrate a computationally practical filtering strategy that could produce early-warning triggers before gravitational radiation from the final merger has arrived at the detectors.

Deep learning for detecting multiple space-time action tubes in videos

Abstract: In this work, we propose an approach to the spatiotemporal localisation (detection) and classification of multiple concurrent actions within temporally untrimmed videos. Our framework is composed of three stages. In stage 1, appearance and motion detection networks are employed to localise and score actions from colour images and optical flow. In stage 2, the appearance network detections are boosted by combining them with the motion detection scores, in proportion to their respective spatial overlap. In stage 3, sequences of detection boxes most likely to be associated with a single action instance, called action tubes, are constructed by solving two energy maximisation problems via dynamic programming. While in the first pass, action paths spanning the whole video are built by linking detection boxes over time using their class-specific scores and their spatial overlap, in the second pass, temporal trimming is performed by ensuring label consistency for all constituting detection boxes. We demonstrate the performance of our algorithm on the challenging UCF101, J-HMDB-21 and LIRIS-HARL datasets, achieving new state-of-the-art results across the board and significantly increasing detection speed at test time.

Integrase and integration: biochemical activities of HIV-1 integrase.

Abstract: Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses integration. The process of integration can be divided into two sequential reactions. The first one, named 3'-processing, corresponds to a specific endonucleolytic reaction which prepares the viral DNA extremities to be competent for the subsequent covalent insertion, named strand transfer, into the host cell genome by a trans-esterification reaction. Recently, a novel specific activity of the full length integrase was reported, in vitro, by our group for two retroviral integrases (HIV-1 and PFV-1). This activity of internal cleavage occurs at a specific palindromic sequence mimicking the LTR-LTR junction described into the 2-LTR circles which are peculiar viral DNA forms found during viral infection. Moreover, recent studies demonstrated the existence of a weak palindromic consensus found at the integration sites. Taken together, these data underline the propensity of retroviral integrases for binding symmetrical sequences and give perspectives for targeting specific sequences used for gene therapy.

Design, Synthesis, Structural and Nonlinear Optical Properties of Photochromic Crystals: Toward Reversible Molecular Switches

Abstract: Two new anil molecules exhibiting photochromism in the crystalline state, N-(4-hydroxy)-salicylidene-amino-4-(methylbenzoate) (2) and N-(3,5-di-tert-butylsalicylidene)-4-aminopyridine (3), are obtained. Upon irradiation in the UV, the yellow crystals change color to red, owing to enol-keto intramolecular tautomerism. The red color disappears, when crystals are left in the dark or irradiated with visible light. 3 has the most stable keto form among all anil-type photochromic compounds (τ = 460 days at room temperature). Both exhibit nonlinear optical (NLO) properties and show powder second harmonic generation (SHG) of respectively 10 and 3 times vs urea. X-ray diffraction shows acentric structures where molecules line up “head-to-tail” through hydrogen bonds for 2 (space group Pc), or form a chiral helix 3 (space group P32). Evidence of reversible structural change is given for 3, and we demonstrate the functionality of this crystal as an NLO switching material, as SHG can be photomodulated by about 30%.