École normale supérieure de Cachan

About: École normale supérieure de Cachan is a education organization based out in Cachan, Île-de-France, France. It is known for research contribution in the topics: Decidability & Finite element method. The organization has 2717 authors who have published 5585 publications receiving 175925 citations.

Mauvaise réduction des variétés de Drinfeld et correspondance de Langlands locale

Abstract: Pour F d’egale caracteristique positive p differente de l, Laumon, Rapoport et Stuhler ([17]) ont prouve la correspondance de Langlands locale, c’est-a-dire l’existence d’une famille de bijections LF,d : AG Ld ∼ −→ G(d), d ≥ 1, possedant certaines proprietes de conservation de facteurs L et e (cf. le paragraphe 1.2 pour un enonce precis). En particulier pour d = 1, L1,F est induit par l’isomorphisme W ab F ' F× de la theorie du corps de classe abelien. Dans [12], Henniart a demontre la correspondance de Jacquet-Langlands locale, c’est-a-dire l’existence, pour tout d ≥ 1, d’une

Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA

Abstract: Replication of human cytomegalovirus (CMV) requires the expression of the viral mitochondria-localized inhibitor of apoptosis (vMIA). vMIA inhibits apoptosis by recruiting Bax to mitochondria, resulting in its neutralization. We show that vMIA decreases cell size, reduces actin polymerization, and induces cell rounding. As compared with vMIA-expressing CMV, vMIA-deficient CMV, which replicates in fibroblasts expressing the adenoviral apoptosis suppressor E1B19K, induces less cytopathic effects. These vMIA effects can be separated from its cell death-inhibitory function because vMIA modulates cellular morphology in Bax-deficient cells. Expression of vMIA coincided with a reduction in the cellular adenosine triphosphate (ATP) level. vMIA selectively inhibited one component of the ATP synthasome, namely, the mitochondrial phosphate carrier. Exposure of cells to inhibitors of oxidative phosphorylation produced similar effects, such as an ATP level reduced by 30%, smaller cell size, and deficient actin polymerization. Similarly, knockdown of the phosphate carrier reduced cell size. Our data suggest that the cytopathic effect of CMV can be explained by vMIA effects on mitochondrial bioenergetics.

Formation of ultracold fermionic NaLi Feshbach molecules

Abstract: We describe the formation of fermionic NaLi Feshbach molecules from an ultracold mixture of bosonic ${}^{23}$Na and fermionic ${}^{6}$Li. Precise magnetic field sweeps across a narrow Feshbach resonance at 745 G result in a molecule conversion fraction of $5%$ for our experimental densities and temperatures, corresponding to a molecule number of $5\ifmmode\times\else\texttimes\fi{}{10}^{4}$. The observed molecular decay lifetime is $1.3$ ms after removing free Li and Na atoms from the trap. Due to its extremely low reactivity, NaLi molecules in the ground state will have a much longer lifetime than KRb.