scispace - formally typeset
Search or ask a question

Showing papers by "École Polytechnique Fédérale de Lausanne published in 1999"


Journal ArticleDOI
TL;DR: A predictive control scheme is proposed which is able to stabilize MLD systems on desired reference trajectories while fulfilling operating constraints, and possibly take into account previous qualitative knowledge in the form of heuristic rules.

2,980 citations


Book
23 Aug 1999
TL;DR: Duncan Watts uses the small-world phenomenon--colloquially called "six degrees of separation"--as a prelude to a more general exploration: under what conditions can a small world arise in any kind of network?
Abstract: Everyone knows the small-world phenomenon: soon after meeting a stranger, we are surprised to discover that we have a mutual friend, or we are connected through a short chain of acquaintances. In his book, Duncan Watts uses this intriguing phenomenon--colloquially called "six degrees of separation"--as a prelude to a more general exploration: under what conditions can a small world arise in any kind of network?The networks of this story are everywhere: the brain is a network of neurons; organisations are people networks; the global economy is a network of national economies, which are networks of markets, which are in turn networks of interacting producers and consumers. Food webs, ecosystems, and the Internet can all be represented as networks, as can strategies for solving a problem, topics in a conversation, and even words in a language. Many of these networks, the author claims, will turn out to be small worlds.How do such networks matter? Simply put, local actions can have global consequences, and the relationship between local and global dynamics depends critically on the network's structure. Watts illustrates the subtleties of this relationship using a variety of simple models---the spread of infectious disease through a structured population; the evolution of cooperation in game theory; the computational capacity of cellular automata; and the sychronisation of coupled phase-oscillators.Watts's novel approach is relevant to many problems that deal with network connectivity and complex systems' behaviour in general: How do diseases (or rumours) spread through social networks? How does cooperation evolve in large groups? How do cascading failures propagate through large power grids, or financial systems? What is the most efficient architecture for an organisation, or for a communications network? This fascinating exploration will be fruitful in a remarkable variety of fields, including physics and mathematics, as well as sociology, economics, and biology.

2,404 citations


Journal ArticleDOI
TL;DR: In this article, the Activated Sludge Model No. 3 (ASM3) is proposed to predict oxygen consumption, sludge production, nitrification and denitrification of activated sludge systems.

2,108 citations


Journal ArticleDOI
01 Jul 1999
TL;DR: The basic concepts of watermarking systems are outlined and illustrated with proposed water marking methods for images, video, audio, text documents, and other media.
Abstract: Multimedia watermarking technology has evolved very quickly during the last few years. A digital watermark is information that is imperceptibly and robustly embedded in the host data such that it cannot be removed. A watermark typically contains information about the origin, status, or recipient of the host data. In this tutorial paper, the requirements and applications for watermarking are reviewed. Applications include copyright protection, data monitoring, and data tracking. The basic concepts of watermarking systems are outlined and illustrated with proposed watermarking methods for images, video, audio, text documents, and other media. Robustness and security aspects are discussed in detail. Finally, a few remarks are made about the state of the art and possible future developments in watermarking technology.

1,447 citations


Journal ArticleDOI
TL;DR: In this article, the authors presented a method to construct an LNNME-ARTICLE-1999-004, which is used in PhysRevLett.82.944.
Abstract: Reference LNNME-ARTICLE-1999-004doi:10.1103/PhysRevLett.82.944View record in Web of Science Record created on 2007-04-23, modified on 2016-08-08

1,447 citations


Journal ArticleDOI
TL;DR: A variety of outstanding experimental results on the elucidation of the elastic properties of carbon nanotubes are fast appearing as discussed by the authors, which are based mainly on the techniques of high-resolution transmission electron microscopy and atomic force microscopy (AFM) to determine the Young's moduli of single-wall nanotube bundles and multi-walled nanotubels.
Abstract: A variety of outstanding experimental results on the elucidation of the elastic properties of carbon nanotubes are fast appearing. These are based mainly on the techniques of high-resolution transmission electron microscopy (HRTEM) and atomic force microscopy (AFM) to determine the Young’s moduli of single-wall nanotube bundles and multi-walled nanotubes, prepared by a number of methods. These results are confirming the theoretical predictions that carbon nanotubes have high strength plus extraordinary flexibility and resilience. As well as summarising the most notable achievements of theory and experiment in the last few years, this paper explains the properties of nanotubes in the wider context of materials science and highlights the contribution of our research group in this rapidly expanding field. A deeper understanding of the relationship between the structural order of the nanotubes and their mechanical properties will be necessary for the development of carbon-nanotube-based composites. Our research to date illustrates a qualitative relationship between the Young’s modulus of a nanotube and the amount of disorder in the atomic structure of the walls. Other exciting results indicate that composites will benefit from the exceptional mechanical properties of carbon nanotubes, but that the major outstanding problem of load transfer efficiency must be overcome before suitable engineering materials can be produced.

1,362 citations


Journal ArticleDOI
TL;DR: Based on the direct 3D analysis of human bone biopsies, it appears that samples with a lower bone mass are primarily characterized by a smaller plate‐to‐rod ratio, and to a lesser extent by thinner trabecular elements.
Abstract: The appearance of cancellous bone architecture is different for various skeletal sites and various disease states. During aging and disease, plates are perforated and connecting rods are dissolved. There is a continuous shift from one structural type to the other. So traditional histomorphometric procedures, which are based on a fixed model type, will lead to questionable results. The introduction of three-dimensional (3D) measuring techniques in bone research makes it possible to capture the actual architecture of cancellous bone without assumptions of the structure type. This requires, however, new methods that make direct use of the 3D information. Within the framework of a BIOMED I project of the European Union, we analyzed a total of 260 human bone biopsies taken from five different skeletal sites (femoral head, vertebral bodies L2 and L4, iliac crest, and calcaneus) from 52 donors. The samples were measured three-dimensionally with a microcomputed tomography scanner and subsequently evaluated with both traditional indirect histomorphometric methods and newly developed direct ones. The results show significant differences between the methods and in their relation to the bone volume fraction. Based on the direct 3D analysis of human bone biopsies, it appears that samples with a lower bone mass are primarily characterized by a smaller plate-to-rod ratio, and to a lesser extent by thinner trabecular elements.

1,326 citations


Journal ArticleDOI
03 Dec 1999-Science
TL;DR: Quality control improves folding efficiency by retaining proteins in the special folding environment of the endoplasmic reticulum, and it prevents harmful effects that could be caused by the deployment of incompletely folded or assembled proteins.
Abstract: A variety of quality control mechanisms operate in the endoplasmic reticulum and in downstream compartments of the secretory pathway to ensure the fidelity and regulation of protein expression during cell life and differentiation. As a rule, only proteins that pass a stringent selection process are transported to their target organelles and compartments. If proper maturation fails, the aberrant products are degraded. Quality control improves folding efficiency by retaining proteins in the special folding environment of the endoplasmic reticulum, and it prevents harmful effects that could be caused by the deployment of incompletely folded or assembled proteins.

1,214 citations


Journal ArticleDOI
TL;DR: A new application of digital holography for phase-contrast imaging and optical metrology and an application to surface profilometry shows excellent agreement with contact-stylus probe measurements.
Abstract: We present a new application of digital holography for phase-contrast imaging and optical metrology. This holographic imaging technique uses a CCD camera for recording of a digital Fresnel off-axis hologram and a numerical method for hologram reconstruction. The method simultaneously provides an amplitude-contrast image and a quantitative phase-contrast image. An application to surface profilometry is presented and shows excellent agreement with contact-stylus probe measurements.

1,202 citations


Journal ArticleDOI
26 Aug 1999-Nature
TL;DR: Evidence is provided that ngn3 acts as pro-endocrine gene and that Notch signalling is critical for the decision between theendocrine and progenitor/exocrine fates in the developing pancreas.
Abstract: The pancreas contains both exocrine and endocrine cells, but the molecular mechanisms controlling the differentiation of these cell types are largely unknown. Despite their endodermal origin, pancreatic endocrine cells share several molecular characteristics with neurons, and, like neurons in the central nervous system, differentiating endocrine cells in the pancreas appear in a scattered fashion within a field of progenitor cells. This indicates that they may be generated by lateral specification through Notch signalling. Here, to test this idea, we analysed pancreas development in mice genetically altered at several steps in the Notch signalling pathway. Mice deficient for Delta-like gene 1 (Dll1) or the intracellular mediator RBP-JK showed accelerated differentiation of pancreatic endocrine cells. A similar phenotype was observed in mice over-expressing neurogenin 3(ngn 3) or the intracellular form of Notch3 (ref. 13) (a repressor of Notch signalling). These data provide evidence that ngn3 acts as pro-endocrine gene and that Notch signalling is critical for the decision between theendocrine and progenitor/exocrine fates in the developing pancreas.

1,185 citations


Journal ArticleDOI
TL;DR: Off-axis holograms recorded with a magnified image of microscopic objects are numerically reconstructed in amplitude and phase by calculation of scalar diffraction in the Fresnel approximation to show that the transverse resolution is equal to the diffraction limit of the imaging system.
Abstract: We present a digital method for holographic microscopy involving a CCD camera as a recording device. Off-axis holograms recorded with a magnified image of microscopic objects are numerically reconstructed in amplitude and phase by calculation of scalar diffraction in the Fresnel approximation. For phase-contrast imaging the reconstruction method involves the computation of a digital replica of the reference wave. A digital method for the correction of the phase aberrations is presented. We present a detailed description of the reconstruction procedure and show that the transverse resolution is equal to the diffraction limit of the imaging system.

Book ChapterDOI
TL;DR: The basic concepts of MPC are reviewed, the uncertainty descriptions considered in the MPC literature are surveyed, and the techniques proposed for robust constraint handling, stability, and performance are surveyed.
Abstract: This paper gives an overview of robustness in Model Predictive Control (MPC). After reviewing the basic concepts of MPC, we survey the uncertainty descriptions considered in the MPC literature, and the techniques proposed for robust constraint handling, stability, and performance. The key concept of “closedloop prediction” is discussed at length. The paper concludes with some comments on future research directions.

Journal ArticleDOI
TL;DR: The effect of deprotonation on the performance of these complexes as photosensitizers for nanocrystalline titania was investigated.
Abstract: The ruthenium complexes [Ru(dcbpyH2)2(Cl)2] (1), [Ru(dcbpyH2)2(NCS)2] (2), (Bu4N)4[Ru(dcbpy)2(NCS)2] (3), and (Bu4N)2[Ru(dcbpyH)2(NCS)2] (4) were synthesized and characterized by cyclic voltammetry, UV−vis absorption, and emission, IR, Raman, and NMR spectroscopy. The absorption and emission maxima of these complexes red shifted with decreasing pH, and showed pH-dependent excited-state lifetimes. The ground-state pKa values were determined by spectrophotometeric methods, and the dissociation of protons was found to occur in two steps (pKa = 3 and 1.5). The Ru(II)/(III) couple in the complex (Bu4N)4[Ru(dcbpy)2(NCS)2] is shifted ca. 290 mV negatively with regard to that of the complex [Ru(dcbpyH2)2(NCS)2] due to the replacement of H+ by tetrabutylammonium cation. The negative shift for the dcbpy-based reduction potential is even larger, i.e., about 600 mV compared to that of the complex [Ru(dcbpyH2)2(NCS)2]. The effect of deprotonation on the performance of these complexes as photosensitizers for nanocrysta...

Journal ArticleDOI
TL;DR: This poster presents a probabilistic procedure to constrain the number of particles in the response of the immune system to the presence of Tau.
Abstract: Reference LPI-ARTICLE-1999-017View record in Web of Science Record created on 2006-02-21, modified on 2017-05-12

Journal ArticleDOI
TL;DR: In this paper, the transition between the regimes of cw mode locking and Q-switched mode locking was investigated, and an extended theory that took into account nonlinear soliton-shaping effects and gain filtering was developed.
Abstract: The use of a saturable absorber as a passive mode locker in a solid-state laser can introduce a tendency for Q-switched mode-locked operation. We have investigated the transition between the regimes of cw mode locking and Q-switched mode locking. Experimental data from Nd:YLF lasers in the picosecond domain and soliton mode-locked Nd:glass lasers in the femtosecond domain, both passively mode locked with semiconductor saturable absorber mirrors, were compared with predictions from an analytical model. The observed stability limits for the picosecond lasers agree well with a previously described model, while for soliton mode-locked femtosecond lasers we have developed an extended theory that takes into account nonlinear soliton-shaping effects and gain filtering. © 1999 Optical Society of America [S0740-3224(99)01001-2] OCIS codes: 140.3580, 140.4050, 140.3540, 140.7090.

Journal ArticleDOI
TL;DR: In this article, a new criterion for the appearance of hot tears in metallic alloys is proposed, based upon a mass balance performed over the liquid and solid phases, which accounts for the tensile deformation of the solid skeleton perpendicular to the growing dendrites and for the induced interdendritic liquid feeding.
Abstract: A new criterion for the appearance of hot tears in metallic alloys is proposed. Based upon a mass balance performed over the liquid and solid phases, it accounts for the tensile deformation of the solid skeleton perpendicular to the growing dendrites and for the induced interdendritic liquid feeding. This model introduces a critical deformation rate ( $$\dot \varepsilon _{p,\max } $$ ) beyond which cavitation, i.e., nucleation of a first void, occurs. As should be expected, this critical value is an increasing function of the thermal gradient and permeability and a decreasing function of the viscosity. The shrinkage contribution, which is also included in the model, is shown to be of the same order of magnitude as that associated with the tensile deformation of the solid skeleton. A hot-cracking sensitivity (HCS) index is then defined as $$\dot \varepsilon _{_{p,\max } }^{ - 1} $$ . When applied to a variable-concentration aluminum-copper alloy, this HCS criterion can reproduce the typical “Λ curves” previously deduced by Clyne and Davies on a phenomenological basis. The calculated values are in fairly good agreement with those obtained experimentally by Spittle and Cushway for a non-grain-refined alloy. A comparison of this criterion to hot cracks observed in ring-mold solidification tests indicates cavitation depression of a few kilo Pascal and tensile stresses in the coherent mushy zone of a few mega Pascal. These values are discussed in terms of those obtained by other means (coherency measurement, microporosity observation, and simulation). Even though this HCS criterion is based only upon the appearance of a first void and not on its propagation, it sets up for the first time a physically sound basis for the study of hot-crack formation.

Journal ArticleDOI
TL;DR: Although airborne laser scanning competes to a certain extent with photogrammetry and will replace it in certain cases, the two technologies are fairly complementary and their integration can lead to more accurate and complete products, and open up new areas of application.
Abstract: A comparison between data acquisition and processing from passive optical sensors and airborne laser scanning is presented. A short overview and the major differences between the two technologies are outlined. Advantages and disadvantages with respect to various aspects are discussed, like sensors, platforms, flight planning, data acquisition conditions, imaging, object reflectance, automation, accuracy, flexibility and maturity, production time and costs. A more detailed comparison is presented with respect to DTM and DSM generation. Strengths of laser scanning with respect to certain applications are outlined. Although airborne laser scanning competes to a certain extent with photogrammetry and will replace it in certain cases, the two technologies are fairly complementary and their integration can lead to more accurate and complete products, and open up new areas of application.

Journal ArticleDOI
TL;DR: A correlation-based ~‘‘Hebbian’’ ! learning rule at a spike level with millisecond resolution is formulated, mathematically analyzed, and compared with learning in a firing-rate description.
Abstract: A correlation-based ~‘‘Hebbian’’ ! learning rule at a spike level with millisecond resolution is formulated, mathematically analyzed, and compared with learning in a firing-rate description. The relative timing of presynaptic and postsynaptic spikes influences synaptic weights via an asymmetric ‘‘learning window.’’ A differential equation for the learning dynamics is derived under the assumption that the time scales of learning and neuronal spike dynamics can be separated. The differential equation is solved for a Poissonian neuron model with stochastic spike arrival. It is shown that correlations between input and output spikes tend to stabilize structure formation. With an appropriate choice of parameters, learning leads to an intrinsic normalization of the average weight and the output firing rate. Noise generates diffusion-like spreading of synaptic weights. @S1063-651X~99!02804-4#


Journal ArticleDOI
TL;DR: In this article, Between et al. found that the comparative risk propensity of male and female subjects is strongly dependent on the financial decision setting and observed no gender differences in risk propensity when subjects face contextual decisions.
Abstract: 40 males, 33 females gain-gambling (gain domain) loss-gambling (loss domain) a Contextual frames. b Abstract gambling frames. studies, the application of experimental methods provided stronger control of the economic environment in which decisions were made. We elicited data which call into question the prevalence of stereotypic risk attitudes in financial decision-making. First, we find that the comparative risk propensity of male and female subjects is strongly dependent on the financial decision setting. Second, and more important, we observe no gender differences in risk propensity when subjects face contextual decisions. Since in practice financial decisions are always contextual, our results suggest that the above gender stereotype may not reflect true male and female attitudes toward financial risks. I. Gender-Specific Risk Behavior: An Experimental Design Our experiment was designed to examine gender-specific risk propensity in decisions relevant for investors and managers. Table 1 gives an overview of the experimental design. In the main treatment, we implemented risky choices in the form of investment and insurance decisions. Choice behavior in this treatment (henceforth called the context treatment) directly measures the risk behavior of male and female subjects in contextual financial decisions. We also ran a control treatment in which the same risky choices were presented as abstract gambling decisions. This control treatment (henceforth called the abstract treatment) allows us to validate the risk behavior induced by our experimental procedure in the light of the above-mentioned gambling evidence. In the context treatment, subjects were confronted with risky choices in two different decision contexts. Subjects first had to complete a series of investment decisions. They were then presented with a series of identical choices, this time, however, framed as insur1 Wealth effects from income differences outside the laboratory may still affect risk behavior in our experiment. They are controlled for in our model. 2 Experimental instructions are available in German from the authors or in English from our web page: »www.wif.ethz.ch/publikationen.htm... . ance decisions. Each investment and insurance decision incorporated a choice between a risky lottery and a certain payoff. With the series of choices implemented in the two frames we elicited our subjects’ certainty equivalents for the same four risky lotteries (L1, L2, L3, L4) in both contexts. We implemented two frames in the context treatment in order to measure the risk propensity of subjects toward both perceived gains and perceived losses. In both frames, all possible payoffs for each decision were positive. In the investment frame these payoffs were also presented as gains, while in the insurance frame the same payoffs were presented as losses relative to an initial endowment. Therefore, elicited certainty equivalents in the investment frame measure subjects’ risk propensities in the gain domain, while certainty equivalents in the insurance frame measure risk propensity in the loss domain. If, in contextual financial decisions, female subjects are generally more risk-averse than men, our results should display, ceteris paribus, lower female certainty equivalents in both the investment and insurance frames. 3 The four lotteries (L1, L2, L3, and L4) each had two possible outcomes. Payoffs in Swiss francs (1 SFr A $0.60) and their probabilities were (30 SFr, /6; 10 SFr, /6) , (30 SFr, /2; 10 SFr, /2) , (30 SFr, /6; 10 SFr, /6) , and (50 SFr, /2; 20 SFr, /2) , respectively. 4 Experimental evidence suggests that individual risk propensity will vary systematically between the gain and loss domain ( Daniel Kahneman and Amos Tversky, 1979). 383 VOL. 89 NO. 2 GENDER AND ECONOMIC TRANSACTIONS / 3y16 my68 Mp 383 Friday Dec 10 08:20 AM LP–AER my68 FIGURE 1. DIFFERENCES IN MEAN CERTAINTY EQUIVALENTS (CE) BETWEEN MALE AND FEMALE SUBJECTS, BY FRAME Note: Certainty equivalents ( and male – female differences) are measured in Swiss francs. In the abstract treatment we confronted a different group of subjects with exactly the same risky decisions as those in the main treatment. However, as mentioned before, all choices in this control treatment were framed as abstract gambling decisions. Again, two frames were implemented. In the gaingambling and loss-gambling frames we measured the risk attitudes of subjects toward gambles in the gain and loss domain, respectively. Subjects in both treatments were told in advance that one of their choices would determine their experimental earnings. Further, all subjects completed a post-experimental questionnaire which yielded information on each subject’s disposable income. This information is necessary to exclude wealth effects due to income differences outside the laboratory as an explanation of gender-specific choice behavior.

Book ChapterDOI
TL;DR: A review of the current state of knowledge about the behavior of colloids in porous media and their role in contaminant transport can be found in this paper, where the authors identify some important future research needs.
Abstract: Publisher Summary It is noted that colloidal particles can be effectively transported through subsurface porous media under certain hydrogeochemical conditions. If present in large concentrations, mobile colloids can act as carriers for strongly sorbing contaminants and thereby provide an unretarded transport pathway for contaminants that are otherwise strongly retarded. This potential transport pathway can be considered in risk assessments of sites heavily contaminated with toxic chemicals, such as certain radionuclides, heavy metals, and hydrophobic organic compounds. The chapter reviews the current state of knowledge about the behavior of colloids in porous media and their role in contaminant transport. The chapter also identifies some important future research needs. Colloids are commonly defined as small particles or other entities with dimensions roughly between 1 nm and 1 μm. These size limits to dissolved molecules on one side and to larger suspended particles on the other side. Colloidal particles remain stable in suspension over long time periods, unless they coagulate to form larger aggregates or deposit onto surfaces of larger grains.

Journal ArticleDOI
25 Feb 1999-Nature
TL;DR: In this paper, the authors reported magnetoresistance measurements on individual multi-walled carbon nanotubes and found that the oscillations are in good agreement with theoretical predictions for the Aharonov-Bohm effect in a hollow conductor with a diameter equal to that of the outermost shell of the nanotube.
Abstract: When electrons pass through a cylindrical electrical conductor aligned in a magnetic field, their wave-like nature manifests itself as a periodic oscillation in the electrical resistance as a function of the enclosed magnetic flux1. This phenomenon reflects the dependence of the phase of the electron wave on the magnetic field, known as the Aharonov–Bohm effect2, which causes a phase difference, and hence interference, between partial waves encircling the conductor in opposite directions. Such oscillations have been observed in micrometre-sized thin-walled metallic cylinders3,4,5 and lithographically fabricated rings6,7,8. Carbon nanotubes9,10 are composed of individual graphene sheets rolled into seamless hollow cylinders with diameters ranging from 1 nm to about 20 nm. They are able to act as conducting molecular wires11,12,13,14,15,16,17,18, making them ideally suited for the investigation of quantum interference at the single-molecule level caused by the Aharonov–Bohm effect. Here we report magnetoresistance measurements on individual multi-walled nanotubes, which display pronounced resistance oscillations as a function of magnetic flux.We find that the oscillations are in good agreement with theoretical predictions for the Aharonov–Bohm effect in a hollow conductor with a diameter equal to that of the outermost shell of the nanotubes. In some nanotubes we also observe shorter-period oscillations, which might result from anisotropic electron currents caused by defects in the nanotube lattice.

Journal ArticleDOI
01 Jul 1999-Bone
TL;DR: The results suggest that the determination of mechanical properties of bone and the diagnosis of osteoporosis can be improved if, in addition to BMD, the 3D bone microarchitecture is assessed in vivo.

Journal ArticleDOI
TL;DR: In this article, the similarity solutions describing the steady plane (flow and thermal) boundary layers on an exponentially stretching continuous surface with an exponential temperature distribution are examined both analytically and numerically.
Abstract: The similarity solutions describing the steady plane (flow and thermal) boundary layers on an exponentially stretching continuous surface with an exponential temperature distribution are examined both analytically and numerically. The mass- and heat-transfer characteristics of these boundary layers are described and compared with the results of earlier authors, obtained under the more familiar power-law boundary conditions.

Proceedings ArticleDOI
TL;DR: An evaluation procedure of image watermarking systems is presented and how to efficiently evaluate the watermark performance in such a way that fair comparisons between different methods are possible is shown.
Abstract: Since the early 90s a number of papers on 'robust' digital watermarking systems have been presented but none of them uses the same robustness criteria. This is not practical at all for comparison and slows down progress in this area. To address this issue, we present an evaluation procedure of image watermarking systems. First we identify all necessary parameters for proper benchmarking and investigate how to quantitatively describe the image degradation introduced by the watermarking process. For this, we show the weaknesses of usual image quality measures in the context watermarking and propose a novel measure adapted to the human visual system. Then we show how to efficiently evaluate the watermark performance in such a way that fair comparisons between different methods are possible. The usefulness of three graphs: 'attack vs. visual-quality,' 'bit-error vs. visual quality,' and 'bit-error vs. attack' are investigated. In addition the receiver operating characteristic (ROC) graphs are reviewed and proposed to describe statistical detection behavior of watermarking methods. Finally we review a number of attacks that any system should survive to be really useful and propose a benchmark and a set of different suitable images.

Journal ArticleDOI
TL;DR: In this article, a new distributed temperature-index model is proposed to capture both the pronounced diurnal melt cycles and the spatial variations in melt due to the effects of surrounding topography.
Abstract: Hourly melt and discharge of Storglaciaren, a small glacier in Sweden, were computed for two melt seasons, applying temperature-index methods to a 30 m resolution grid for the melt component. The classical degree-day method yielded a good simulation of the seasonal patient of discharge, but the pronounced melt-induced daily discharge cycles were not captured. Modelled degree-day factors calculated for every hour and each gridcell from melt obtained from a distributed energy-balance model varied substantially, both diurnally and spatially. A new distributed temperature-index model is suggested, attempting to capture both the pronounced diurnal melt cycles and the spatial variations in melt due to the effects of surrounding topography. This is accomplished by including a radiation index in terms of potential clear-sky direct solar radiation, and thus, without the need for other data besides air temperature. This approach improved considerably the simulation of diurnal discharge fluctuations and yielded a more realistic spatial distribution of melt rates. The incorporation of measured global radiation to account for the reduction in direct solar radiation due to cloudiness did not lead to additional improvement in model performance.

Journal ArticleDOI
TL;DR: In this paper, month-long integrations with a regional climate model covering Europe and the Northern Atlantic are utilized to study the sensitivity of the summertime European precipitation climate with respect to the continental-scale soil moisture content.
Abstract: Month-long integrations with a regional climate model covering Europe and the Northern Atlantic are utilized to study the sensitivity of the summertime European precipitation climate with respect to the continental-scale soil moisture content. Experiments are conducted for July 1990 and 1993. For each of the two months, the control experiment with the initial soil water distribution derived from the operational ECMWF analysis is compared against two sensitivity experiments with dry and wet initial soil moisture distributions. The results demonstrate that summertime European precipitation climate in a belt ∼1000 km wide between the wet Atlantic and the dry Mediterranean climate heavily depends upon the soil moisture content. In this belt, changes in monthly mean precipitation amount to about half of the changes in mean evapotranspiration. Budget analysis of water substance over selected subdomains demonstrate that the simulated sensitivity cannot be interpreted with the classical recycling mechani...

Journal ArticleDOI
TL;DR: The γ2+/– mice represent a model of anxiety characterized by harm avoidance behavior and an explicit memory bias for threat cues, resulting in heightened sensitivity to negative associations.
Abstract: Patients with panic disorders show a deficit of GABAA receptors in the hippocampus, parahippocampus and orbitofrontal cortex. Synaptic clustering of GABAA receptors in mice heterozygous for the gamma2 subunit was reduced, mainly in hippocampus and cerebral cortex. The gamma2 +/- mice showed enhanced behavioral inhibition toward natural aversive stimuli and heightened responsiveness in trace fear conditioning and ambiguous cue discrimination learning. Implicit and spatial memory as well as long-term potentiation in hippocampus were unchanged. Thus gamma2 +/- mice represent a model of anxiety characterized by harm avoidance behavior and an explicit memory bias for threat cues, resulting in heightened sensitivity to negative associations. This model implicates GABAA-receptor dysfunction in patients as a causal predisposition to anxiety disorders.

Journal ArticleDOI
TL;DR: Insight is provided into the biosynthetic regulation of antimicrobial compounds, the number of factors for intensive study in situ is limited, and factors that can be manipulated to improve bacterial inoculants are indicated.
Abstract: Understanding the environmental factors that regulate the biosynthesis of antimicrobial compounds by disease-suppressive strains of Pseudomonas fluorescens is an essential step toward improving the level and reliability of their biocontrol activity. We used liquid culture assays to identify several minerals and carbon sources which had a differential influence on the production of the antibiotics 2,4-diacetylphloroglucinol (PHL), pyoluteorin (PLT), and pyrrolnitrin and the siderophores salicylic acid and pyochelin by the model strain CHA0, which was isolated from a natural disease-suppressive soil in Switzerland. Production of PHL was stimulated by Zn2+, NH4Mo2+, and glucose; the precursor compound mono-acetylphloroglucinol was stimulated by the same factors as PHL. Production of PLT was stimulated by Zn2+, Co2+, and glycerol but was repressed by glucose. Pyrrolnitrin production was increased by fructose, mannitol, and a mixture of Zn2+ and NH4Mo2+. Pyochelin production was increased by Co2+, fructose, mannitol, and glucose. Interestingly, production of its precursor salicylic acid was increased by different factors, i.e., NH4Mo2+, glycerol, and glucose. The mixture of Zn2+ and NH4Mo2+ with fructose, mannitol, or glycerol further enhanced the production of PHL and PLT compared with either the minerals or the carbon sources used alone, but it did not improve siderophore production. Extending fermentation time from 2 to 5 days increased the accumulation of PLT, pyrrolnitrin, and pyochelin but not of PHL. When findings with CHA0 were extended to an ecologically and genetically diverse collection of 41 P. fluorescens biocontrol strains, the effect of certain factors was strain dependent, while others had a general effect. Stimulation of PHL by Zn2+ and glucose was strain dependent, whereas PLT production by all strains that can produce this compound was stimulated by Zn2+ and transiently repressed by glucose. Inorganic phosphate reduced PHL production by CHA0 and seven other strains tested but to various degrees. Production of PLT but not pyrrolnitrin by CHA0 was also reduced by 100 mM phosphate. The use of 1/10-strength nutrient broth-yeast extract, compared with standard nutrient broth-yeast extract, amended with glucose and/or glycerol resulted in dramatically increased accumulations of PHL (but not PLT), pyochelin, and salicylic acid, indicating that the ratio of carbon source to nutrient concentration played a key role in the metabolic flow. The results of this study (i) provide insight into the biosynthetic regulation of antimicrobial compounds, (ii) limit the number of factors for intensive study in situ, and (iii) indicate factors that can be manipulated to improve bacterial inoculants.

Journal ArticleDOI
TL;DR: The Web of Science Record was created on 2007-04-23, modified on 2016-08-08 as discussed by the authors, with a modified version of the record created on 2017-07-08.
Abstract: Reference LNNME-ARTICLE-1999-005doi:10.1002/(SICI)1521-4095(199902)11:2 3.0.CO;2-JView record in Web of Science Record created on 2007-04-23, modified on 2016-08-08