scispace - formally typeset
Search or ask a question
Institution

École Polytechnique Fédérale de Lausanne

FacilityLausanne, Switzerland
About: École Polytechnique Fédérale de Lausanne is a facility organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Catalysis. The organization has 44041 authors who have published 98296 publications receiving 4372092 citations. The organization is also known as: EPFL & ETHL.


Papers
More filters
Posted Content
TL;DR: This overview presents the general principles of CLASS, a new accurate Boltzmann code designed to offer a more user-friendly and flexible coding environment to cosmologists, and insists on the friendliness and flexibility aspects.
Abstract: The Cosmic Linear Anisotropy Solving System (CLASS) is a new accurate Boltzmann code, designed to offer a more user-friendly and flexible coding environment to cosmologists. CLASS is very structured, easy to modify, and offers a rigorous way to control the accuracy of output quantities. It is also incidentally a bit faster than other codes. In this overview, we present the general principles of CLASS and its basic structure. We insist on the friendliness and flexibility aspects, while accuracy, physical approximations and performances are discussed in a series of companion papers.

679 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present a methodology for estimating the seasonal and interannual variation of biomass burning designed for use in global chemical transport models, using the Total Ozone Mapping Spectrometer (TOMS) Aerosol Index (AI) data set.
Abstract: We present a methodology for estimating the seasonal and interannual variation of biomass burning designed for use in global chemical transport models. The average seasonal variation is estimated from 4 years of fire-count data from the Along Track Scanning Radiometer (ATSR) and 1-2 years of similar data from the Advanced Very High Resolution Radiometer (AVHRR) World Fire Atlases. We use the Total Ozone Mapping Spectrometer (TOMS) Aerosol Index (AI) data product as a surrogate to estimate interannual variability in biomass burning for six regions: Southeast Asia, Indonesia and Malaysia, Brazil, Central America and Mexico, Canada and Alaska, and Asiatic Russia. The AI data set is available from 1979 to the present with an interruption in satellite observations from mid-1993 to mid-1996; this data gap is filled where possible with estimates of area burned from the literature for different regions. Between August 1996 and July 2000, the ATSR fire-counts are used to provide specific locations of emissions and a record of interannual variability throughout the world. We use our methodology to estimate mean seasonal and interannual variations for emissions of carbon monoxide from biomass burning, and we find that no trend is apparent in these emissions over the last two decades, but that there is significant interannual variability.

678 citations

Journal ArticleDOI
TL;DR: The deletion of the poly(ADP-ribose) polymerase-1 (PARP-1) gene, encoding a major NAD(+)-consuming enzyme, increases NAD(+) content and SIRT1 activity in brown adipose tissue and muscle and the pharmacologic inhibition of PARP in vitro and in vivo is shown.

678 citations

Journal ArticleDOI
TL;DR: The Web of Science Record was created on 2006-02-21, modified on 2017-05-12 by as discussed by the authors, and was used for the LPI-ARTICLE-2000-012 abstract.
Abstract: Reference LPI-ARTICLE-2000-012View record in Web of Science Record created on 2006-02-21, modified on 2017-05-12

678 citations

Journal ArticleDOI
TL;DR: It is proposed that the different molecular composition and higher phosphorylation of FAs on supermature islets, compared with FAs with classical islet status, accounts for higher stress resistance.
Abstract: Expression of α-smooth muscle actin (α-SMA) renders fibroblasts highly contractile and hallmarks myofibroblast differentiation. We identify α-SMA as a mechanosensitive protein that is recruited to stress fibers under high tension. Generation of this threshold tension requires the anchoring of stress fibers at sites of 8–30-μm-long “supermature” focal adhesions (suFAs), which exert a stress approximately fourfold higher (∼12 nN/μm2) on micropatterned deformable substrates than 2–6-μm-long classical FAs. Inhibition of suFA formation by growing myofibroblasts on substrates with a compliance of ≤11 kPa and on rigid micropatterns of 6-μm-long classical FA islets confines α-SMA to the cytosol. Reincorporation of α-SMA into stress fibers is established by stretching 6-μm-long classical FAs to 8.1-μm-long suFA islets on extendable membranes; the same stretch producing 5.4-μm-long classical FAs from initially 4-μm-long islets is without effect. We propose that the different molecular composition and higher phosphorylation of FAs on supermature islets, compared with FAs on classical islets, accounts for higher stress resistance.

677 citations


Authors

Showing all 44420 results

NameH-indexPapersCitations
Michael Grätzel2481423303599
Ruedi Aebersold182879141881
Eliezer Masliah170982127818
Richard H. Friend1691182140032
G. A. Cowan1592353172594
Ian A. Wilson15897198221
Johan Auwerx15865395779
Menachem Elimelech15754795285
A. Artamonov1501858119791
Melody A. Swartz1481304103753
Henry J. Snaith146511123155
Kurt Wüthrich143739103253
Richard S. J. Frackowiak142309100726
Jean-Paul Kneib13880589287
Kevin J. Tracey13856182791
Network Information
Related Institutions (5)
ETH Zurich
122.4K papers, 5.1M citations

98% related

Massachusetts Institute of Technology
268K papers, 18.2M citations

96% related

Georgia Institute of Technology
119K papers, 4.6M citations

96% related

Centre national de la recherche scientifique
382.4K papers, 13.6M citations

96% related

University of Illinois at Urbana–Champaign
225.1K papers, 10.1M citations

94% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023234
2022704
20215,247
20205,644
20195,432
20185,094