Institution
École Polytechnique Fédérale de Lausanne
Facility•Lausanne, Switzerland•
About: École Polytechnique Fédérale de Lausanne is a facility organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Catalysis. The organization has 44041 authors who have published 98296 publications receiving 4372092 citations. The organization is also known as: EPFL & ETHL.
Topics: Population, Catalysis, Computer science, Laser, Context (language use)
Papers published on a yearly basis
Papers
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Friedrich Miescher Institute for Biomedical Research1, Centre national de la recherche scientifique2, Vision Institute3, Pierre-and-Marie-Curie University4, École Polytechnique Fédérale de Lausanne5, University of Tübingen6, Center for Integrated Protein Science Munich7, Trinity College, Dublin8, Stanford University9
TL;DR: It is shown that expression of archaebacterial halorhodopsin in light-insensitive cones can substitute for the native phototransduction cascade and restore light sensitivity in mouse models of retinitis pigmentosa.
Abstract: Retinitis pigmentosa refers to a diverse group of hereditary diseases that lead to incurable blindness, affecting two million people worldwide. As a common pathology, rod photoreceptors die early, whereas light-insensitive, morphologically altered cone photoreceptors persist longer. It is unknown if these cones are accessible for therapeutic intervention. Here, we show that expression of archaebacterial halorhodopsin in light-insensitive cones can substitute for the native phototransduction cascade and restore light sensitivity in mouse models of retinitis pigmentosa. Resensitized photoreceptors activate all retinal cone pathways, drive sophisticated retinal circuit functions (including directional selectivity), activate cortical circuits, and mediate visually guided behaviors. Using human ex vivo retinas, we show that halorhodopsin can reactivate light-insensitive human photoreceptors. Finally, we identified blind patients with persisting, light-insensitive cones for potential halorhodopsin-based therapy.
601 citations
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TL;DR: A model of spike timing–dependent plasticity (STDP) in which synaptic changes depend on presynaptic spike arrival and the postsynaptic membrane potential, filtered with two different time constants is created and found that the plasticity rule led not only to development of localized receptive fields but also to connectivity patterns that reflect the neural code.
Abstract: Electrophysiological connectivity patterns in cortex often have a few strong connections, which are sometimes bidirectional, among a lot of weak connections. To explain these connectivity patterns, we created a model of spike timing-dependent plasticity (STDP) in which synaptic changes depend on presynaptic spike arrival and the postsynaptic membrane potential, filtered with two different time constants. Our model describes several nonlinear effects that are observed in STDP experiments, as well as the voltage dependence of plasticity. We found that, in a simulated recurrent network of spiking neurons, our plasticity rule led not only to development of localized receptive fields but also to connectivity patterns that reflect the neural code. For temporal coding procedures with spatio-temporal input correlations, strong connections were predominantly unidirectional, whereas they were bidirectional under rate-coded input with spatial correlations only. Thus, variable connectivity patterns in the brain could reflect different coding principles across brain areas; moreover, our simulations suggested that plasticity is fast.
601 citations
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TL;DR: In this paper, a distributed controller for secondary frequency and voltage control in islanded microgrids is proposed, which uses localized information and nearest-neighbor communication to collectively perform secondary control actions.
Abstract: In this paper, we present new distributed controllers for secondary frequency and voltage control in islanded microgrids. Inspired by techniques from cooperative control, the proposed controllers use localized information and nearest-neighbor communication to collectively perform secondary control actions. The frequency controller rapidly regulates the microgrid frequency to its nominal value while maintaining active power sharing among the distributed generators. Tuning of the voltage controller provides a simple and intuitive tradeoff between the conflicting goals of voltage regulation and reactive power sharing. Our designs require no knowledge of the microgrid topology, impedances, or loads. The distributed architecture allows for flexibility and redundancy, eliminating the need for a central microgrid controller. We provide a voltage stability analysis and present extensive experimental results validating our designs, verifying robust performance under communication failure and during plug-and-play operation.
600 citations
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TL;DR: In this paper, the decomposition of three clayey structures (kaolinite, illite and montmorillonite) when thermally treated at 600 degrees C and 800 degrees C was investigated and the effect of this treatment on their pozzolanic activity in cementitious materials.
600 citations
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TL;DR: The computationally determined activation energies for halide ion (vacancy) migration are in excellent agreement with the experimentally determined values, suggesting that the migration of this species causes the observed hysteretic behaviour of these solar cells.
Abstract: CH3NH3PbX3 (MAPbX3) perovskites have attracted considerable attention as absorber materials for solar light harvesting, reaching solar to power conversion efficiencies above 20%. In spite of the rapid evolution of the efficiencies, the understanding of basic properties of these semiconductors is still ongoing. One phenomenon with so far unclear origin is the so-called hysteresis in the current-voltage characteristics of these solar cells. Here we investigate the origin of this phenomenon with a combined experimental and computational approach. Experimentally the activation energy for the hysteretic process is determined and compared with the computational results. First-principles simulations show that the timescale for MA(+) rotation excludes a MA-related ferroelectric effect as possible origin for the observed hysteresis. On the other hand, the computationally determined activation energies for halide ion (vacancy) migration are in excellent agreement with the experimentally determined values, suggesting that the migration of this species causes the observed hysteretic behaviour of these solar cells.
600 citations
Authors
Showing all 44420 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Grätzel | 248 | 1423 | 303599 |
Ruedi Aebersold | 182 | 879 | 141881 |
Eliezer Masliah | 170 | 982 | 127818 |
Richard H. Friend | 169 | 1182 | 140032 |
G. A. Cowan | 159 | 2353 | 172594 |
Ian A. Wilson | 158 | 971 | 98221 |
Johan Auwerx | 158 | 653 | 95779 |
Menachem Elimelech | 157 | 547 | 95285 |
A. Artamonov | 150 | 1858 | 119791 |
Melody A. Swartz | 148 | 1304 | 103753 |
Henry J. Snaith | 146 | 511 | 123155 |
Kurt Wüthrich | 143 | 739 | 103253 |
Richard S. J. Frackowiak | 142 | 309 | 100726 |
Jean-Paul Kneib | 138 | 805 | 89287 |
Kevin J. Tracey | 138 | 561 | 82791 |