École Polytechnique Fédérale de Lausanne

About: École Polytechnique Fédérale de Lausanne is a facility organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Catalysis. The organization has 44041 authors who have published 98296 publications receiving 4372092 citations. The organization is also known as: EPFL & ETHL.

Lactate in the brain: from metabolic end-product to signalling molecule

Abstract: Lactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to neuronal activity signals. Thus, neurons and astrocytes show tight metabolic coupling. Lactate is transferred from astrocytes to neurons to match the neuronal energetic needs, and to provide signals that modulate neuronal functions, including excitability, plasticity and memory consolidation. In addition, lactate affects several homeostatic functions. Overall, lactate ensures adequate energy supply, modulates neuronal excitability levels and regulates adaptive functions in order to set the 'homeostatic tone' of the nervous system.

The genetic basis of singlet oxygen-induced stress responses of Arabidopsis thaliana.

Abstract: Plants under oxidative stress suffer from damages that have been interpreted as unavoidable consequences of injuries inflicted upon plants by toxic levels of reactive oxygen species (ROS). However, this paradigm needs to be modified. Inactivation of a single gene, EXECUTER1, is sufficient to abrogate stress responses of Arabidopsis thaliana caused by the release of singlet oxygen: External conditions under which these stress responses are observed and the amounts of ROS that accumulate in plants exposed to these environmental conditions do not directly cause damages. Instead, seedling lethality and growth inhibition of mature plants result from genetic programs that are activated after the release of singlet oxygen has been perceived by the plant.

Fair benchmark for image watermarking systems

Abstract: Since the early 90s a number of papers on 'robust' digital watermarking systems have been presented but none of them uses the same robustness criteria. This is not practical at all for comparison and slows down progress in this area. To address this issue, we present an evaluation procedure of image watermarking systems. First we identify all necessary parameters for proper benchmarking and investigate how to quantitatively describe the image degradation introduced by the watermarking process. For this, we show the weaknesses of usual image quality measures in the context watermarking and propose a novel measure adapted to the human visual system. Then we show how to efficiently evaluate the watermark performance in such a way that fair comparisons between different methods are possible. The usefulness of three graphs: 'attack vs. visual-quality,' 'bit-error vs. visual quality,' and 'bit-error vs. attack' are investigated. In addition the receiver operating characteristic (ROC) graphs are reviewed and proposed to describe statistical detection behavior of watermarking methods. Finally we review a number of attacks that any system should survive to be really useful and propose a benchmark and a set of different suitable images.

TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays.

Abstract: Cell migration plays a major role in development, physiology, and disease, and is frequently evaluated in vitro by the monolayer wound healing assay. The assay analysis, however, is a time-consumin...