École Polytechnique Fédérale de Lausanne

About: École Polytechnique Fédérale de Lausanne is a facility organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Catalysis. The organization has 44041 authors who have published 98296 publications receiving 4372092 citations. The organization is also known as: EPFL & ETHL.

A distributed temperature-index ice- and snowmelt model including potential direct solar radiation

Abstract: Hourly melt and discharge of Storglaciaren, a small glacier in Sweden, were computed for two melt seasons, applying temperature-index methods to a 30 m resolution grid for the melt component. The classical degree-day method yielded a good simulation of the seasonal patient of discharge, but the pronounced melt-induced daily discharge cycles were not captured. Modelled degree-day factors calculated for every hour and each gridcell from melt obtained from a distributed energy-balance model varied substantially, both diurnally and spatially. A new distributed temperature-index model is suggested, attempting to capture both the pronounced diurnal melt cycles and the spatial variations in melt due to the effects of surrounding topography. This is accomplished by including a radiation index in terms of potential clear-sky direct solar radiation, and thus, without the need for other data besides air temperature. This approach improved considerably the simulation of diurnal discharge fluctuations and yielded a more realistic spatial distribution of melt rates. The incorporation of measured global radiation to account for the reduction in direct solar radiation due to cloudiness did not lead to additional improvement in model performance.

Dimensional tailoring of hybrid perovskites for photovoltaics

Abstract: Hybrid perovskites are currently one of the most active fields of research owing to their enormous potential for photovoltaics. The performance of 3D hybrid organic–inorganic perovskite solar cells has increased at an incredible rate, reaching power conversion efficiencies comparable to those of many established technologies. However, the commercial application of 3D hybrid perovskites is inhibited by their poor stability. Relative to 3D hybrid perovskites, low-dimensional — that is, 2D — hybrid perovskites have demonstrated higher moisture stability, offering new approaches to stabilizing perovskite-based photovoltaic devices. Furthermore, 2D hybrid perovskites have versatile structures, enabling the fine-tuning of their optoelectronic properties through compositional engineering. In this Review, we discuss the state of the art in 2D perovskites, providing an overview of structural and materials engineering aspects and optical and photophysical properties. Moreover, we discuss recent developments along with the main limitations of 3D perovskites and assess the advantages of 2D perovskites over their 3D parent structures in terms of stability. Finally, we review recent achievements in combining 3D and 2D perovskites as an approach to simultaneously boost device efficiency and stability, paving the way for mixed-dimensional perovskite solar cells for commercial applications. Combining low-dimensional and 3D perovskites is a promising approach to achieve stable and efficient solar cells. In this Review, we discuss the structural, optical and photophysical properties of low-dimensional perovskites, compare the stability and efficiency of 2D and 3D perovskite devices, and consider 2D/3D composites as a strategy to increase the stability of perovskite solar cells.

Classical and Non-Classical Ruthenium-Based Anticancer Drugs: Towards Targeted Chemotherapy

Abstract: Ruthenium-based anticancer chemotherapies are making significant advances in clinical trials. Until recently, the focus has been on coordination complexes, and mechanisms such as "activation by reduction" and "transferrin-targeted delivery" have been proposed to account for the excellent cytotoxicity and low general toxicity of these complexes. More recently organoruthenium compounds, which to some extent appear not to follow the established rules, have started to be investigated. Despite such differences, similar activities between certain coordination and organometallic compounds suggest similar modes of action are present. DNA, the classic target, is believed to be the dominant mechanism for cytotoxicity with certain ruthenium drugs, while with others, non-classical targets are thought to be more important. In this article we describe these features and show how both ruthenium coordination complexes and organoruthenium compounds represent an ideal scaffold for further drug design and optimisation.

Diagnosing performance overheads in the xen virtual machine environment

Abstract: Virtual Machine (VM) environments (e.g., VMware and Xen) are experiencing a resurgence of interest for diverse uses including server consolidation and shared hosting. An application's performance in a virtual machine environment can differ markedly from its performance in a non-virtualized environment because of interactions with the underlying virtual machine monitor and other virtual machines. However, few tools are currently available to help debug performance problems in virtual machine environments.In this paper, we present Xenoprof, a system-wide statistical profiling toolkit implemented for the Xen virtual machine environment. The toolkit enables coordinated profiling of multiple VMs in a system to obtain the distribution of hardware events such as clock cycles and cache and TLB misses. The toolkit will facilitate a better understanding of performance characteristics of Xen's mechanisms allowing the community to optimize the Xen implementation.We use our toolkit to analyze performance overheads incurred by networking applications running in Xen VMs. We focus on networking applications since virtualizing network I/O devices is relatively expensive. Our experimental results quantify Xen's performance overheads for network I/O device virtualization in uni- and multi-processor systems. With certain Xen configurations, networking workloads in the Xen environment can suffer significant performance degradation. Our results identify the main sources of this overhead which should be the focus of Xen optimization efforts. We also show how our profiling toolkit was used to uncover and resolve performance bugs that we encountered in our experiments which caused unexpected application behavior.

Pore-forming toxins: ancient, but never really out of fashion

Abstract: Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and have long fascinated structural biologists, microbiologists and immunologists. Interestingly, pore-forming proteins with remarkably similar structures to PFTs are found in vertebrates and constitute part of their immune system. Recently, structural studies of several PFTs have provided important mechanistic insights into the metamorphosis of PFTs from soluble inactive monomers to cytolytic transmembrane assemblies. In this Review, we discuss the diverse pore architectures and membrane insertion mechanisms that have been revealed by these studies, and we consider how these features contribute to binding specificity for different membrane targets. Finally, we explore the potential of these structural insights to enable the development of novel therapeutic strategies that would prevent both the establishment of bacterial resistance and an excessive immune response.