Institution
École Polytechnique Fédérale de Lausanne
Facility•Lausanne, Switzerland•
About: École Polytechnique Fédérale de Lausanne is a facility organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Catalysis. The organization has 44041 authors who have published 98296 publications receiving 4372092 citations. The organization is also known as: EPFL & ETHL.
Topics: Population, Catalysis, Laser, Thin film, Perovskite (structure)
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
1,096 citations
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TL;DR: This work shows from experimental data that the homogeneous nucleation of ice from supercooled aqueous solutions is independent of the nature of the solute, but depends only on the water activity of the solution, and presents a thermodynamic theory for homogeneous ice nucleation, which expresses the nucleation rate coefficient as a function of water activity and pressure.
Abstract: The unique properties of water in the supercooled (metastable) state are not fully understood. In particular, the effects of solutes and mechanical pressure on the kinetics of the liquid-to-solid phase transition of supercooled water and aqueous solutions to ice have remained unresolved. Here we show from experimental data that the homogeneous nucleation of ice from supercooled aqueous solutions is independent of the nature of the solute, but depends only on the water activity of the solution--that is, the ratio between the water vapour pressures of the solution and of pure water under the same conditions. In addition, we show that the presence of solutes and the application of pressure have a very similar effect on ice nucleation. We present a thermodynamic theory for homogeneous ice nucleation, which expresses the nucleation rate coefficient as a function of water activity and pressure. Recent observations from clouds containing ice are in good agreement with our theory and our results should help to overcome one of the main weaknesses of numerical models of the atmosphere, the formulation of cloud processes.
1,093 citations
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TL;DR: In this paper, the influence of the presence of limestone on the hydration of Portland cement was investigated, and it was shown that the stabilisation of monocarbonate in the absence of limestone indirectly stabilised ettringite, leading to a corresponding increase of the total volume of the hydrate phase and a decrease of porosity.
1,089 citations
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TL;DR: Two loci close to NKX6.3/MIR486 and RBSG4 are identified in the Canadian discovery cohort and replicated in the DiOGenes cohort and taken forward for Bayesian fine-mapping and functional assessment in flies.
Abstract: Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains unknown. We perform a GWAS in two large low-caloric diet intervention cohorts of obese participants. Two loci close to NKX6.3/MIR486 and RBSG4 are identified in the Canadian discovery cohort (n = 1166) and replicated in the DiOGenes cohort (n = 789). Modulation of HGTX (NKX6.3 ortholog) levels in Drosophila melanogaster leads to significantly altered triglyceride levels. Additional tissue-specific experiments demonstrate an action through the oenocytes, fly hepatocyte-like cells that regulate lipid metabolism. Our results identify genetic variants associated with the efficacy of weight loss in obese subjects and identify a role for NKX6.3 in lipid metabolism, and thereby possibly weight control. Individuals show large variability in their capacity to lose weight and maintain this weight. Here, the authors perform GWAS in two weight loss intervention cohorts and identify two genetic loci associated with weight loss that are taken forward for Bayesian fine-mapping and functional assessment in flies.
1,085 citations
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TL;DR: Gaining a better understanding of the crosstalk between dendritic cells and lymphatic vessels during the migration of d endritic cells to lymph nodes is essential for future advances in manipulating dendrite-cell migration as a means to fine-tune immune responses in clinical settings.
Abstract: Antigen-presenting dendritic cells often acquire foreign antigens in peripheral tissues such as the skin. Optimal encounter with naive T cells for the presentation of these antigens requires that the dendritic cells migrate to draining lymph nodes through lymphatic vessels. In this article, we review important aspects of what is known about dendritic-cell trafficking into and through lymphatic vessels to lymph nodes. We present these findings in the context of information about lymphatic-vessel biology. Gaining a better understanding of the crosstalk between dendritic cells and lymphatic vessels during the migration of dendritic cells to lymph nodes is essential for future advances in manipulating dendritic-cell migration as a means to fine-tune immune responses in clinical settings.
1,082 citations
Authors
Showing all 44420 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Grätzel | 248 | 1423 | 303599 |
Ruedi Aebersold | 182 | 879 | 141881 |
Eliezer Masliah | 170 | 982 | 127818 |
Richard H. Friend | 169 | 1182 | 140032 |
G. A. Cowan | 159 | 2353 | 172594 |
Ian A. Wilson | 158 | 971 | 98221 |
Johan Auwerx | 158 | 653 | 95779 |
Menachem Elimelech | 157 | 547 | 95285 |
A. Artamonov | 150 | 1858 | 119791 |
Melody A. Swartz | 148 | 1304 | 103753 |
Henry J. Snaith | 146 | 511 | 123155 |
Kurt Wüthrich | 143 | 739 | 103253 |
Richard S. J. Frackowiak | 142 | 309 | 100726 |
Jean-Paul Kneib | 138 | 805 | 89287 |
Kevin J. Tracey | 138 | 561 | 82791 |