Institution
Edinburgh Napier University
Education•Edinburgh, United Kingdom•
About: Edinburgh Napier University is a education organization based out in Edinburgh, United Kingdom. It is known for research contribution in the topics: Population & Health care. The organization has 2665 authors who have published 6859 publications receiving 175272 citations.
Papers published on a yearly basis
Papers
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Pennsylvania State University1, Edinburgh Napier University2, Hogeschool van Amsterdam3, University of Amsterdam4, Netherlands Cancer Institute5, University of South Carolina6, Northern Arizona University7, Wingate University8, Harvard University9, Mayo Clinic10, Edith Cowan University11, American Cancer Society12, University of California, San Francisco13, George Mason University14, Kaiser Permanente15, Penn State Cancer Institute16, National Institutes of Health17, Macmillan Cancer Support18, New York University19, Oregon Health & Science University20, University of British Columbia21
TL;DR: There is a call to action for key stakeholders to create the infrastructure and cultural adaptations needed so that all people living with and beyond cancer can be as active as is possible for them.
Abstract: Multiple organizations around the world have issued evidence-based exercise guidance for patients with cancer and cancer survivors. Recently, the American College of Sports Medicine has updated its exercise guidance for cancer prevention as well as for the prevention and treatment of a variety of cancer health-related outcomes (eg, fatigue, anxiety, depression, function, and quality of life). Despite these guidelines, the majority of people living with and beyond cancer are not regularly physically active. Among the reasons for this is a lack of clarity on the part of those who work in oncology clinical settings of their role in assessing, advising, and referring patients to exercise. The authors propose using the American College of Sports Medicine's Exercise Is Medicine initiative to address this practice gap. The simple proposal is for clinicians to assess, advise, and refer patients to either home-based or community-based exercise or for further evaluation and intervention in outpatient rehabilitation. To do this will require care coordination with appropriate professionals as well as change in the behaviors of clinicians, patients, and those who deliver the rehabilitation and exercise programming. Behavior change is one of many challenges to enacting the proposed practice changes. Other implementation challenges include capacity for triage and referral, the need for a program registry, costs and compensation, and workforce development. In conclusion, there is a call to action for key stakeholders to create the infrastructure and cultural adaptations needed so that all people living with and beyond cancer can be as active as is possible for them.
392 citations
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TL;DR: A bibliometric analysis of the literature published between 1992 and 2012 shows that smart-city research is fragmented and lacks cohesion, and its growth follows two main development paths.
Abstract: This paper reports on the first two decades of research on smart cities by conducting a bibliometric analysis of the literature published between 1992 and 2012. The analysis shows that smart-city r...
392 citations
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TL;DR: Some of the most frequently used assays to assess the cytotoxity and biological reactivity of nanoparticles in vitro, ranging from simple cytotoxicity assays, to measurement of reactive oxygen species and oxidative stress, activation of proinflammatory signaling, and finally genotoxicity are outlined.
Abstract: Due to the rapid development of a diverse array of nanoparticles, used in a wide variety of products, there are now many international activities to assess the potential toxicity of these materials. These particles are developed due to properties such as catalytic reactivity, high surface area, light emission properties, and others. Such properties have the potential to interfere in many well-established toxicity testing protocols. This article outlines some of the most frequently used assays to assess the cytotoxity and biological reactivity of nanoparticles in vitro. The article identifies key issues that need to be addressed in relation to inclusion of relevant controls, assessing particles for their ability to interfere in the assays, and using systematic approaches to prevent misinterpretation of data. The protocols discussed range from simple cytotoxicity assays, to measurement of reactive oxygen species and oxidative stress, activation of proinflammatory signaling, and finally genotoxicity. The aim of this review is to share knowledge relating to nanoparticle toxicity testing in order to provide advice and support for guidelines, regulatory bodies, and for scientists in general.
392 citations
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TL;DR: Ultrafine particles of two very different materials induced inflammation and epithelial damage to a greater extent than their fine counterparts, suggesting that there are differences in the likely harmfulness of different types of ultrafine particle.
Abstract: Background: Ultrafine particles have been hypothesised to be an important contributing factor in the toxicity and adverse health effects of particulate air pollution (PM10) and nanoparticles are used increasingly in industrial processes.
Aims: To compare the ability of ultrafine and fine particles of titanium dioxide and carbon black to induce inflammation, cause epithelial injury, and affect the alveolar macrophage clearance functions of phagocytosis and chemotaxis in vivo.
Methods: Rats were instilled with fine and ultrafine carbon black and titanium dioxide. Inflammation was quantified by bronchoalveolar lavage; the ability of the macrophages to phagoytose indictor fluorescent beads and to migrate towards aC5a were determined.
Results: Ultrafine particles induced more PMN recruitment, epithelial damage, and cytotoxicity than their fine counterparts, exposed at equal mass. Both ultrafine and fine particles significantly impaired the phagocytic ability of alveolar macrophages. Only ultrafine particle treatment significantly enhanced the sensitivity of alveolar macrophages to chemotact towards C5a.
Conclusions: Ultrafine particles of two very different materials induced inflammation and epithelial damage to a greater extent than their fine counterparts. In general, the effect of ultrafine carbon black was greater than ultrafine titanium dioxide, suggesting that there are differences in the likely harmfulness of different types of ultrafine particle. Epithelial injury and toxicity were associated with the development of inflammation after exposure to ultrafines. Increased sensitivity to a C5a chemotactic gradient could make the ultrafine exposed macrophages more likely to be retained in the lungs, so allowing dose to accumulate.
387 citations
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TL;DR: In this paper, the authors introduce a recherche sur l'Analyse Conceptuelle Formelle (ACF), methode d'analyse de donnees, de representation de connaissances and de gestion de l'information.
Abstract: L'article constitue une introduction a la recherche sur l'Analyse Conceptuelle Formelle (ACF), methode d'analyse de donnees, de representation de connaissances et de gestion de l'information, et ses applications en sciences de l'information. Apres un rappel des notions de base de l'ACF (connexion de Galois, treillis conceptuels, echelles conceptuelles) et leurs relations avec des notions similaires dans d'autres domaines, l'A. s'interesse a l'utilisation des outils de l'ACF pour la recherche d'information, la representation et la decouverte de connaissances, la logique et l'intelligence artificielle.
382 citations
Authors
Showing all 2727 results
Name | H-index | Papers | Citations |
---|---|---|---|
William MacNee | 123 | 472 | 58989 |
Richard J. Simpson | 113 | 850 | 59378 |
Ken Donaldson | 109 | 385 | 47072 |
John Campbell | 107 | 1150 | 56067 |
Muhammad Imran | 94 | 3053 | 51728 |
Barbara Rothen-Rutishauser | 70 | 339 | 17348 |
Vicki Stone | 69 | 204 | 25002 |
Sharon K. Parker | 68 | 238 | 21089 |
Matt Nicholl | 66 | 224 | 15208 |
John H. Adams | 66 | 354 | 16169 |
Darren J. Kelly | 65 | 252 | 13007 |
Neil B. McKeown | 65 | 281 | 19371 |
Jane K. Hill | 62 | 147 | 20733 |
Min Du | 61 | 326 | 11328 |
Xiaodong Liu | 60 | 474 | 14980 |