Institution
Edinburgh Napier University
Education•Edinburgh, United Kingdom•
About: Edinburgh Napier University is a education organization based out in Edinburgh, United Kingdom. It is known for research contribution in the topics: Population & Health care. The organization has 2665 authors who have published 6859 publications receiving 175272 citations.
Papers published on a yearly basis
Papers
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TL;DR: Discriminant analysis of morphometric data showed that normal male specimens from the most polluted site resembled pooled intersex males, suggesting that subtle endocrine disruption (ED) maybe occurring in these otherwise apparently normal males.
73 citations
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TL;DR: A comprehensive secondary-based synthesis of previous studies on the profile and patterns of consumption of Generation Y, their consumption experiences and the role of information communication technologies and social media in determining their emerging patterns of behaviour at visitor attractions is presented in this paper.
Abstract: This study provides a comprehensive secondary-based synthesis of previous studies on the profile and patterns of consumption of Generation Y, their consumption experiences and the role of information communication technologies and social media in determining their emerging patterns of behaviour at visitor attractions. The paper concludes by advancing a management-oriented attraction research framework specific to Generation Y with a set of research propositions proposed to stimulate further research and management action on this specific and highly influential generational cohort. Copyright © 2013 John Wiley & Sons, Ltd.
73 citations
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TL;DR: The need for post-match fatigue monitoring is debated, the real-world relevance of the current research literature is critique, the practical burden relating to measurement tools and protocols, and the collection, interpretation and application of data in the field are discussed.
Abstract: Participation in soccer match-play leads to acute and transient subjective, biochemical, metabolic and physical disturbances in players over subsequent hours and days. Inadequate time for rest and regeneration between matches can expose players to the risk of training and competing whilst not entirely recovered. In professional soccer, contemporary competitive schedules can require teams to compete in excess of 60 matches over the course of the season with periods of fixture congestion occurring, prompting much attention from researchers and practitioners to the monitoring of fatigue and readiness to play. A comprehensive body of research has investigated post-match acute and residual fatigue responses. Yet the relevance of the research for professional soccer contexts is debatable, notably in relation to the study populations and designs employed. Monitoring can indeed be invasive, expensive, time inefficient, and difficult to perform routinely and simultaneously in a large squad of regularly competing players. Uncertainty also exists regarding the meaningfulness and interpretation of changes in fatigue response values and their functional relevance, and practical applicability in the field. The real-world need and cost-benefit of monitoring must be carefully weighed up. In relation to professional soccer contexts, this opinion paper intends to (1) debate the need for post-match fatigue monitoring; (2) critique the real-world relevance of the current research literature; (3) discuss the practical burden relating to measurement tools and protocols, and the collection, interpretation and application of data in the field; and (4) propose future research perspectives.
73 citations
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TL;DR: This study suggests that the presence of activated epithelial cells and the exposure of basement membrane that occurs in asthma, together with oxidant stress, may facilitate the colonisation of the asthmatic lung by A fumigatus.
Abstract: BACKGROUND: Aspergillus fumigatus is an opportunistic pathogen to which asthmatic subjects are particularly susceptible. The ability of spores of A fumigatus to bind to pulmonary cells and basement membrane proteins was investigated to determine the mechanisms involved in this susceptibility. METHODS: Cells of the A549 pulmonary epithelial cell line or purified basement membrane proteins were immobilised on the wells of microtitre plates. They were then exposed to spores of A fumigatus in suspension, with or without various pretreatments of the spores, cells, and proteins. Adherent spores were counted by light microscopy. RESULTS: Spores of A fumigatus bound in a concentration dependent manner to A549 epithelial cells and pretreatment of cells with interferon gamma (2500 units/ml) caused a significant doubling of spore binding. Binding of spores to A549 cells was inhibited by about a third by pre-incubation of the spores with fibrinogen (100 micrograms/ml). Spores bound specifically to extracellular matrix (ECM) components laid down by A549 cells, and pretreatment of the ECM components with hydrogen peroxide (25-80 microM) enhanced spore binding by approximately one third. They also bound specifically and in a saturable manner to purified fibrinogen, fibronectin, laminin, type I collagen, and type IV collagen. Pre-incubation of spores with Arg-Gly-Asp tripeptide (RGD; 50-200 micrograms/ ml) inhibited binding to fibronectin and type I collagen by 50%. CONCLUSIONS: This study suggests that the presence of activated epithelial cells and the exposure of basement membrane that occurs in asthma, together with oxidant stress, may facilitate the colonisation of the asthmatic lung by A fumigatus. The RGD sequence may be involved in spore binding to some ECM proteins. Free fibrinogen may protect against binding of A fumigatus spores to the pulmonary epithelium.
73 citations
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TL;DR: Investigation of the ability of a series of different surface-coated quantum dots (QDs) to cause oxidative stress and affect cell signalling in J774.A1 macrophages concluded that QDs differ in their interactions with macrophage according to their specific surface properties.
Abstract: The aim of this study was to investigate the ability of a series of different surface-coated quantum dots (QDs) to cause oxidative stress and affect cell signalling in J774.A1 macrophages. Organic QDs caused a significant (p < 0.001) decrease in glutathione (GSH) levels over 24 h, while COOH and NH(2) (PEG) QDs induced a significant decrease (p < 0.05) in GSH at 6 and 24 h only. J774.A1 cytosolic Ca(2+) concentration significantly increased (p < 0.01) 30 min after treatment with all QDs. Trolox was, however, able to prevent the COOH and NH(2) (PEG) QD-induced Ca(2+) signal, but not the organic QD induced effect. All QDs tested were observed to have a relatively low ability to stimulate increased expression of the pro-inflammatory cytokine tumour necrosis factor-alpha (TNF-alpha). In conclusion, QDs differ in their interactions with macrophages according to their specific surface properties.
73 citations
Authors
Showing all 2727 results
Name | H-index | Papers | Citations |
---|---|---|---|
William MacNee | 123 | 472 | 58989 |
Richard J. Simpson | 113 | 850 | 59378 |
Ken Donaldson | 109 | 385 | 47072 |
John Campbell | 107 | 1150 | 56067 |
Muhammad Imran | 94 | 3053 | 51728 |
Barbara Rothen-Rutishauser | 70 | 339 | 17348 |
Vicki Stone | 69 | 204 | 25002 |
Sharon K. Parker | 68 | 238 | 21089 |
Matt Nicholl | 66 | 224 | 15208 |
John H. Adams | 66 | 354 | 16169 |
Darren J. Kelly | 65 | 252 | 13007 |
Neil B. McKeown | 65 | 281 | 19371 |
Jane K. Hill | 62 | 147 | 20733 |
Min Du | 61 | 326 | 11328 |
Xiaodong Liu | 60 | 474 | 14980 |