Edinburgh Napier University

About: Edinburgh Napier University is a education organization based out in Edinburgh, United Kingdom. It is known for research contribution in the topics: Population & Health care. The organization has 2665 authors who have published 6859 publications receiving 175272 citations.

Using bio-optics to investigate the extent of coastal waters: A Swedish case study

Abstract: In order to develop an optical model to map the extent of coastal waters, the authors analyzed variations in bio-optical constituents and submarine optical properties along a transect from the nutrient-enriched coastal bay, Himmerfjarden, out into the open Baltic Sea. The model is a simple implementation of the “ecosystem approach,” because the optical constituents are proxies for important components of ecosystem state. Yellow substance or colored dissolved organic matter (CDOM) is often a marker for terrestrial freshwater or decay processes in the littoral zone. Phytoplankton pigments, especially chlorophyll a, are used as a proxy for phytoplankton biomass that may be stimulated by fluvial or coastal inputs of anthropogenic nutrients. Suspended particulate matter (SPM) is placed in suspension by tidal or wind-wave stirring of shallow seabeds, and is therefore an indicator for physical forcing. It is the thesis of this article that such constituents, and the optical properties that they control, can be used to provide an ecological definition of the extent of the coastal zone. The spatial distribution of the observations was analyzed using a steady-state model that assumes diffusional transport of bio-optical variables along an axis perpendicular to the coast. According to the model, the resulting distribution along this axis can be described as a low-order polynomial (of order 1–3) when moving from a “source” associated with land to the open-sea “sink.” Order 1 implies conservative mixing, and the higher orders imply significant biological or chemical processes within the gradient. The analysis of the transect data confirmed that the trend of each optical component could be described well using a low-order polynomial. Multiple regression analysis was then used to weigh the contribution of each optical component to the spectral attenuation coefficient K d(490) along the transect. The results showed that in this Swedish Baltic case study, the inorganic fraction of the SPM may be used to distinguish between coastal and open-sea waters, as it showed a clear break between coastal and open-sea waters. Alternative models may be needed for coastal waters in which fronts interrupt the continuity of mixing.

Analysis of the Mechanism and Regulation of Lactose Transport and Metabolism in Clostridium acetobutylicum ATCC 824

Abstract: Although the acetone-butanol-ethanol fermentation of Clostridium acetobutylicum is currently uneconomic, the ability of the bacterium to metabolize a wide range of carbohydrates offers the potential for revival based on the use of cheap, low-grade substrates. We have investigated the uptake and metabolism of lactose, the major sugar in industrial whey waste, by C. acetobutylicum ATCC 824. Lactose is taken up via a phosphoenolpyruvate-dependent phosphotransferase system (PTS) comprising both soluble and membrane-associated components, and the resulting phosphorylated derivative is hydrolyzed by a phospho-β-galactosidase. These activities are induced during growth on lactose but are absent in glucose-grown cells. Analysis of the C. acetobutylicum genome sequence identified a gene system, lacRFEG, encoding a transcriptional regulator of the DeoR family, IIA and IICB components of a lactose PTS, and phospho-β-galactosidase. During growth in medium containing both glucose and lactose, C. acetobutylicum exhibited a classical diauxic growth, and the lac operon was not expressed until glucose was exhausted from the medium. The presence upstream of lacR of a potential catabolite responsive element (cre) encompassing the transcriptional start site is indicative of the mechanism of carbon catabolite repression characteristic of low-GC gram-positive bacteria. A pathway for the uptake and metabolism of lactose by this industrially important organism is proposed.

A new method for correcting shadow band diffuse irradiance data

Abstract: An instrument commonly used to measure diffuse irradiance is the polar-axis shadow band pyranometer. However, the shadow band that is used to prevent the beam energy from entering the pyranometer also obscures part of sky-diffuse irradiance. A correction factor must hence be applied to obtain as accurate as possible the estimation of the true diffuse irradiance. In this article, the development of a new model based on an anisotropic sky-diffuse distribution theory is presented. The proposed model is validated using two databases from different sites with various sky conditions. Drummond's method, which is based on geometrical calculation, is also examined using the same databases. Comparison of the results obtained through application of the proposed model, with those generated by Drummond's method shows that, for the case of Bracknell, UK the proposed method gives a root mean square error (RMSE) of 12 W/m2, as compared to Drummond's figure of 16 W/m2. For the case of Beer Sheva, Israel the proposed model produces an RMSE of 17 W/m2, while Drummond's procedure results in 23 W/m2. It has been demonstrated herein that the proposed method is not site specific.

Addressing the efficacy of dihydrocodeine versus methadone as an alternative maintenance treatment for opiate dependence: a randomized controlled trial

Abstract: Aim The aim of this study is to define the efficacy of dihydrocodeine as an alternative to methadone in the maintenance treatment of opiate dependence. Design A pragmatic open-label randomized controlled study of patients recommended for opiate maintenance treatment to test equivalence of the two treatment options with followup continuing for up to 42 months after recruitment. Setting Assessment at either Edinburgh’s Community Drug Problem Service or at two general practitioner practices with specialist drug community psychiatric nurses, then with shared care follow-up. Participants Two hundred and thirty-five subjects (168 male, 67 female) with opiate dependence syndrome were recruited. Subjects selected were suitable for opiate maintenance treatment. Routine treatment was offered throughout. Intervention Patients were randomized to receive either methadone mixture 1 mg/ml or dihydrocodeine, 30 mg or 60 mg tablets. Measurements The primary outcome measure was retention in treatment. Eight secondary outcomes included total illicit opiate use, reported crime, physical health, mental health, injecting drug use, overdoses, selling drugs and being in education or work. Measures were compared over 42 months followup. Findings There was no difference in groups for retention in treatment at follow-up and there was improvement in all secondary outcomes from baseline. No significant difference in outcomes was found between randomized groups over time. Compliance with randomized treatment differed by randomized group and was affected by experiences in custody during follow-up. Those randomized to dihydrocodeine were more likely to switch treatments. Conclusions These results, combined with existing clinical experience, provide evidence that dihydrocodeine is a viable alternative to methadone as a maintenance treatment for opiate dependence. Indirect comparisons with other studies show dihydrocodeine (and methadone) to be superior to placebo.