Institution
Edith Cowan University
Education•Perth, Western Australia, Australia•
About: Edith Cowan University is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Tourism. The organization has 4040 authors who have published 13529 publications receiving 339582 citations. The organization is also known as: Edith Cowan & ECU.
Topics: Population, Tourism, Isometric exercise, Higher education, Health care
Papers published on a yearly basis
Papers
More filters
••
Icahn School of Medicine at Mount Sinai1, University of Bonn2, Brandeis University3, Andrés Bello National University4, Medivation5, Edith Cowan University6, University of Toronto7, University of Alberta8, Cornell University9, University of Western Australia10, University of California, Irvine11, Hollywood Private Hospital12, Veterans Health Administration13
TL;DR: It is concluded that LAT possesses pro-autophagic properties in addition to the previously reported pro-neurogenic properties, both of which are potentially relevant to the treatment and/or prevention of neurodegenerative diseases.
Abstract: Latrepirdine (Dimebon) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to moderate Alzheimer's disease, with a dramatically positive outcome in a Russian clinical trial that was unconfirmed in a replication trial in the United States. We sought to determine whether latrepirdine (LAT)-stimulated amyloid precursor protein (APP) catabolism is at least partially attributable to regulation of macroautophagy, a highly conserved protein catabolism pathway that is known to be impaired in brains of patients with Alzheimer's disease (AD). We utilized several mammalian cellular models to determine whether LAT regulates mammalian target of rapamycin (mTOR) and Atg5-dependent autophagy. Male TgCRND8 mice were chronically administered LAT prior to behavior analysis in the cued and contextual fear conditioning paradigm, as well as immunohistological and biochemical analysis of AD-related neuropathology. Treatment of cultured mammalian cells with LAT led to enhanced mTOR- and Atg5-dependent autophagy. Latrepirdine treatment of TgCRND8 transgenic mice was associated with improved learning behavior and with a reduction in accumulation of Aβ42 and α-synuclein. We conclude that LAT possesses pro-autophagic properties in addition to the previously reported pro-neurogenic properties, both of which are potentially relevant to the treatment and/or prevention of neurodegenerative diseases. We suggest that elucidation of the molecular mechanism(s) underlying LAT effects on neurogenesis, autophagy and behavior might warranty the further study of LAT as a potentially viable lead compound that might yield more consistent clinical benefit following the optimization of its pro-neurogenic, pro-autophagic and/or pro-cognitive activities.
105 citations
••
TL;DR: The authors explored undergraduate capabilities in career self-management and the influence of work-integrated learning (WIL) and found that students at one UK and one Australian university consider themselves reasonably proficient in career management yet variations exist across the different dimensions of self-awareness, opportunity awareness, decision-making learning and transition learning.
Abstract: This paper explores undergraduate capabilities in career self-management and the influence of work-integrated learning (WIL). Career management competencies are an important aspect of individual employability and impact on wellbeing, graduate job attainment and long-term career success. Enhanced competencies among graduates can assist Faculty in achieving strong employment outcomes and support industry partners who wish to employ graduates able to self-manage their career pathways effectively amid flatter organisational structures and greater employee mobility. Our findings indicate that business undergraduates at one UK and one Australian university consider themselves reasonably proficient in career self-management yet variations exist across the different dimensions of self-awareness, opportunity awareness, decision-making learning and transition learning. Participation in work placements and study and employment characteristics influenced certain elements of career self-management. Our study h...
105 citations
••
TL;DR: Results of this study suggest that high Aβ levels and Met carriage may be useful prognostic markers of accelerated decline in episodic memory, and reductions in hippocampal volume in individuals in the prodromal or MCI stage of AD.
Abstract: Objective
Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer’s disease (AD). As AD is a neurodegenerative disease, genetic influences may become clearer from prospective study. We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance, hippocampal volume, and Aβ accumulation in adults with amnestic mild cognitive impairment (aMCI) and high Aβ.
105 citations
••
TL;DR: It is highlighted that family members of individuals with aphasia have a number of aphasic-related rehabilitation goals for themselves, which need to be addressed systematically to provide a family-centred approach to rehabilitation.
Abstract: Background: Aphasia affects family members in addition to the individuals with the communication disorder. In order to develop appropriate services for the relatives of people with aphasia post-stroke, their rehabilitation goals need to be identified. Aim: The aim of the current investigation was to identify the rehabilitation goals that family members of individuals with aphasia have for themselves. Methods & Procedures: Forty-eight family members of adults with aphasia post-stroke participated in in-depth semi-structured interviews to identify the rehabilitation goals they had for themselves. All the interviews were transcribed verbatim and analysed using qualitative content analysis. Outcomes & Results: Analysis revealed seven categories of goals that the family members had for themselves: to be included in rehabilitation, to be provided with hope and positivity, to be able to communicate and maintain their relationship with the person with aphasia, to be given information, to be given support, to look after their own well-being, and to be able to cope with new responsibilities. A few participants reported that, at certain times during the rehabilitation process, they did not have any goals for themselves. Conclusions & Implications: This study highlights that family members of individuals with aphasia have a number of aphasia-related rehabilitation goals for themselves. In order to provide a family-centred approach to rehabilitation, health professionals, including speechlanguage pathologists, need systematically to identify and address family members goals in light of the categories revealed in this investigation.
105 citations
••
TL;DR: This paper found that emotional responses to climate change result from perceiving one's "objects of care" as threatened by climate change, which motivates caring about climate change itself, and in turn predicts behaviour.
Abstract: Current research shows that emotions can motivate climate engagement and action, but precisely how has received scant attention. We propose that strong emotional responses to climate change result from perceiving one’s “objects of care” as threatened by climate change, which motivates caring about climate change itself, and in turn predicts behaviour. In two studies, we find that climate scientists (N = 44) experience greater emotional intensity about climate change than do students (N = 94) and the general population (N = 205), and that patterns of emotional responses explain differences in support for climate change policy. Scientists tied their emotional responses to concern about consequences of climate change to future generations and the planet, as well as personal identities associated with responsibility to act. Our findings suggest that “objects of care” that link people to climate change may be crucial to understanding why some people feel more strongly about the issue than others, and how emotions can prompt action.
105 citations
Authors
Showing all 4128 results
Name | H-index | Papers | Citations |
---|---|---|---|
Paul Jackson | 141 | 1372 | 93464 |
William J. Kraemer | 123 | 755 | 54774 |
D. Allan Butterfield | 115 | 504 | 43528 |
Kerry S. Courneya | 112 | 608 | 49504 |
Robert U. Newton | 109 | 753 | 42527 |
Roger A. Barker | 101 | 620 | 39728 |
Ralph N. Martins | 95 | 630 | 35394 |
Wei Wang | 95 | 3544 | 59660 |
David W. Dunstan | 91 | 403 | 37901 |
Peter E.D. Love | 90 | 546 | 24815 |
Andrew Jones | 83 | 695 | 28290 |
Hongqi Sun | 81 | 265 | 20354 |
Leon Flicker | 79 | 465 | 22669 |
Mark A. Jenkins | 79 | 472 | 21100 |
Josep M. Gasol | 77 | 313 | 22638 |