Edith Cowan University

About: Edith Cowan University is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Tourism. The organization has 4040 authors who have published 13529 publications receiving 339582 citations. The organization is also known as: Edith Cowan & ECU.

Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for “Precision Medicine and Pharmacometabolomics Task Group”—The Metabolomics Society Initiative)

Abstract: BACKGROUND: The metabolome of any given biological system contains a diverse range of low molecular weight molecules (metabolites), whose abundances can be affected by the timing and method of sample collection, storage, and handling. Thus, it is necessary to consider the requirements for preanalytical processes and biobanking in metabolomics research. Poor practice can create bias and have deleterious effects on the robustness and reproducibility of acquired data. CONTENT: This review presents both current practice and latest evidence on preanalytical processes and biobanking of samples intended for metabolomics measurement of common biofluids and tissues. It highlights areas requiring more validation and research and provides some evidence-based guidelines on best practices. SUMMARY: Although many researchers and biobanking personnel are familiar with the necessity of standardizing sample collection procedures at the axiomatic level (e.g., fasting status, time of day, “time to freezer,” sample volume), other less obvious factors can also negatively affect the validity of a study, such as vial size, material and batch, centrifuge speeds, storage temperature, time and conditions, and even environmental changes in the collection room. Any biobank or research study should establish and follow a well-defined and validated protocol for the collection of samples for metabolomics research. This protocol should be fully documented in any resulting study and should involve all stakeholders in its design. The use of samples that have been collected using standardized and validated protocols is a prerequisite to enable robust biological interpretation unhindered by unnecessary preanalytical factors that may complicate data analysis and interpretation.

Chat-Line interaction and negative feedback

Abstract: In recent years researchers have investigated the use of Internet applications for language and cultural learning. While this new technology seems to have provided an educational breakthrough, relatively little linguistic research has been conducted particularly in relation to second language acquisition. Therefore the efficacy of the Internet applications not just for cultural studies or the expansion of knowledge, but also for second/foreign language acquisition remains uncertain. This study explores communicative interactions between native speakers (NSs) and non-native speakers (NNSs) of Japanese. Internet Relay Chat (IRC) was chosen as the setting for this study, because of the resemblance of chat line interactions to verbal exchanges. The linguistic focus in this study was specifically on one form of corrective feedback, namely implicit negative feedback (NF), which provides information to language learners about what is unacceptable in target language (e.g. Long, 1996). It has been claimed that NF plays an important facilitative role in language development. Therefore, the aim of this study is to investigate whether NSs provide NF to their NNS interlocutors in interactions during chat line conversations, and whether the NNS’s used this feedback in their subsequent production. The participants were NNSs and NSs of Japanese, formed into 12 gender-matched dyads. Each pair had free on-line “conversation” in three separate sessions. The results show that the proportion of NSs’ NF to the number of NNSs’ non-target-like turns was . lower than that found in the previous studies based on face to face verbal interactions. Even so NF was provided, and it was used – however it remains unclear as to whether or not on-line interactions elicit sufficient NF for acquisition to occur.

The identification and analysis of indicators of community strength and outcomes

Abstract: Provides a review and analysis of literature on the conceptualisation and measurement of community strength and its outcomes and places this information in an analytical framework, identifying the commonalities and differences between various approaches to these issues.