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Institution

Edith Cowan University

EducationPerth, Western Australia, Australia
About: Edith Cowan University is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Tourism. The organization has 4040 authors who have published 13529 publications receiving 339582 citations. The organization is also known as: Edith Cowan & ECU.


Papers
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Journal ArticleDOI
TL;DR: A large body of research has investigated the efficacy of physicotherapeutic, pharmacological, and nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage, with mixed results, and more research is needed to examine if/how these treatments influence inflammation and muscle remodeling during recovery from exercise.
Abstract: Unaccustomed exercise consisting of eccentric (i.e., lengthening) muscle contractions often results in muscle damage characterized by ultrastructural alterations in muscle tissue, clinical signs and symptoms (e.g., reduced muscle strength and range of motion, increased muscle soreness and swelling, efflux of myocellular proteins). The time course of recovery following exercise-induced muscle damage depends on the extent of initial muscle damage, which in turn is influenced by the intensity and duration of exercise, joint angle/muscle length and muscle groups used during exercise. The effects of these factors on muscle strength, soreness and swelling are well characterized. By contrast, much less is known about how they affect intramuscular inflammation and molecular aspects of muscle adaptation/remodeling. Although inflammation has historically been viewed as detrimental for recovery from exercise, it is now generally accepted that inflammatory responses-if tightly regulated-are integral to muscle repair and regeneration. Animal studies have revealed that other cell types including mast cells, eosinophils, CD8 and T regulatory lymphocytes, fibro-adipogenic progenitors and pericytes also help to facilitate muscle tissue regeneration. However, more research is required to determine whether these cells respond to exercise-induced muscle damage. A large body of research has investigated the efficacy of physicotherapeutic, pharmacological and nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage, with mixed results. More research is needed to examine if/how these treatments influence inflammation and muscle remodeling during recovery from exercise.

341 citations

Journal ArticleDOI
D. Fink1
TL;DR: In this paper, the authors investigated the factors that lead to the successful adoption of Information Technology (IT) by Small and Medium Enterprises (SMEs) in today's turbulent times.

340 citations

Journal ArticleDOI
TL;DR: It can be seen that abnormal lipid, cholesterol and glucose metabolism are consistently indicated as central in the pathophysiology, and possibly the pathogenesis of AD.
Abstract: High fat diets and sedentary lifestyles are becoming major concerns for Western countries. They have led to a growing incidence of obesity, dyslipidemia, high blood pressure, and a condition known as the insulin-resistance syndrome or metabolic syndrome. These health conditions are well known to develop along with, or be precursors to atherosclerosis, cardiovascular disease, and diabetes. Recent studies have found that most of these disorders can also be linked to an increased risk of Alzheimer's disease (AD). To complicate matters, possession of one or more apolipoprotein E epsilon4 (APOE epsilon4) alleles further increases the risk or severity of many of these conditions, including AD. ApoE has roles in cholesterol metabolism and Abeta clearance, both of which are thought to be significant in AD pathogenesis. The apparent inadequacies of ApoE epsilon4 in these roles may explain the increased risk of AD in subjects carrying one or more APOE epsilon4 alleles. This review describes some of the physiological and biochemical changes that the above conditions cause, and how they are related to the risk of AD. A diversity of topics is covered, including cholesterol metabolism, glucose regulation, diabetes, insulin, ApoE function, amyloid precursor protein metabolism, and in particular their relevance to AD. It can be seen that abnormal lipid, cholesterol and glucose metabolism are consistently indicated as central in the pathophysiology, and possibly the pathogenesis of AD. As diagnosis of mild cognitive impairment and early AD are becoming more reliable, and as evidence is accumulating that health conditions such as diabetes, obesity, and coronary artery disease are risk factors for AD, appropriate changes to diets and lifestyles will likely reduce AD risk, and also improve the prognosis for people already suffering from such conditions.

339 citations

Journal ArticleDOI
TL;DR: In depth studies on the distribution and expression of nestin in mitotically active cells indicate a complex role in regulation of the assembly and disassembly of intermediate filaments which together with other structural proteins, participate in remodeling of the cell.
Abstract: Nestin is an intermediate filament protein expressed in dividing cells during the early stages of development in the CNS, PNS and in myogenic and other tissues. Upon differentiation, nestin becomes downregulated and is replaced by tissue-specific intermediate filament proteins. Interestingly, nestin expression is reinduced in the adult during pathological situations, such as the formation of the glial scar after CNS injury and during regeneration of injured muscle tissue. Although it is utilised as a marker of proliferating and migrating cells very little is known about its functions or regulation. In depth studies on the distribution and expression of nestin in mitotically active cells indicate a complex role in regulation of the assembly and disassembly of intermediate filaments which together with other structural proteins, participate in remodeling of the cell. The role of nestin in dynamic cells, particularly structural organisation of the cell, appears strictly regulated by phosphorylation, especially its integration into heterogeneous intermediate filaments together with vimentin or alpha-internexin.

339 citations

Book ChapterDOI
09 Mar 2005
TL;DR: The WFG Toolkit is flexible, allowing characteristics such as bias, multi-modality, and non-separability to be incorporated and combined as desired, and a wide variety of Pareto optimal geometries are supported.
Abstract: This paper presents a new toolkit for creating scalable multi-objective test problems. The WFG Toolkit is flexible, allowing characteristics such as bias, multi-modality, and non-separability to be incorporated and combined as desired. A wide variety of Pareto optimal geometries are also supported, including convex, concave, mixed convex/concave, linear, degenerate, and disconnected geometries. All problems created by the WFG Toolkit are well defined, are scalable with respect to both the number of objectives and the number of parameters, and have known Pareto optimal sets. Nine benchmark multi-objective problems are suggested, including one that is both multi-modal and non-separable, an important combination of characteristics that is lacking among existing (scalable) multi-objective problems.

338 citations


Authors

Showing all 4128 results

NameH-indexPapersCitations
Paul Jackson141137293464
William J. Kraemer12375554774
D. Allan Butterfield11550443528
Kerry S. Courneya11260849504
Robert U. Newton10975342527
Roger A. Barker10162039728
Ralph N. Martins9563035394
Wei Wang95354459660
David W. Dunstan9140337901
Peter E.D. Love9054624815
Andrew Jones8369528290
Hongqi Sun8126520354
Leon Flicker7946522669
Mark A. Jenkins7947221100
Josep M. Gasol7731322638
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202350
2022156
20211,433
20201,372
20191,213
20181,023