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Institution

Edith Cowan University

EducationPerth, Western Australia, Australia
About: Edith Cowan University is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Tourism. The organization has 4040 authors who have published 13529 publications receiving 339582 citations. The organization is also known as: Edith Cowan & ECU.


Papers
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Journal ArticleDOI
TL;DR: Evidence from animal and human trials indicates that bone responds positively to impact activities and high intensity progressive resistance training, and the optimisation of muscle strength, balance and mobility minimises the risk of falls.

208 citations

Journal ArticleDOI
TL;DR: By using a pyramid sampling approach combined with simulated reannealing the authors find that registration can be achieved to predetermined precision, subject to choice of interpolation and the constraint of time.
Abstract: The registration of retinal images is required to facilitate the study of the optic nerve head and the retina. The method the authors propose combines the use of mutual information as the similarity measure and simulated annealing as the search technique. It is robust toward large transformations between the images and significant changes in light intensity. By using a pyramid sampling approach combined with simulated reannealing the authors find that registration can be achieved to predetermined precision, subject to choice of interpolation and the constraint of time. The algorithm was tested on 49 pairs of stereo images and 48 pairs of temporal images with success.

207 citations

25 Jun 2007
TL;DR: In this paper, the authors argue that design-based research is feasible for doctoral students, and that candidates should be encouraged to engage in it more specifically, they describe the components of a dissertation proposal or prospectus that utilizes designbased research methods in the context of educational technology research.
Abstract: At first glance, design-based research may appear to be such a long-term and intensive approach to educational inquiry that doctoral students, most of whom expect to complete their PhD degree in 4-5 years, should not attempt to adopt this approach for their doctoral dissertations In this paper, we argue that design-based research is feasible for doctoral students, and that candidates should be encouraged to engage in it More specifically, we describe the components of a dissertation proposal or prospectus that utilizes design-based research methods in the context of educational technology research

207 citations

Journal ArticleDOI
TL;DR: In this paper, a spongy bone-like graphene-silicon carbide (SiC) aerogels were fabricated by the directional freeze-casting of graphene oxide (GO) coated SiC whiskers slurry and thermal reduction of GO@SiC aerogel.

206 citations

Journal ArticleDOI
TL;DR: It is shown that the discriminative ability of GRS in LOAD prediction is maximised when selecting a small number of SNPs, and the number of causal common SNPs for LOAD may be less than 100, suggesting LOAD is more oligogenic than polygenic.
Abstract: Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (Poptimal) of a genetic risk score (GRS) for prediction of LOAD in three independent datasets comprising 676 cases and 35,675 family history proxy cases. We show that the discriminative ability of GRS in LOAD prediction is maximised when selecting a small number of SNPs. Both simulation results and direct estimation indicate that the number of causal common SNPs for LOAD may be less than 100, suggesting LOAD is more oligogenic than polygenic. The best GRS explains approximately 75% of SNP-heritability, and individuals in the top decile of GRS have ten-fold increased odds when compared to those in the bottom decile. In addition, 14 variants are identified that contribute to both LOAD risk and age at onset of LOAD.

206 citations


Authors

Showing all 4128 results

NameH-indexPapersCitations
Paul Jackson141137293464
William J. Kraemer12375554774
D. Allan Butterfield11550443528
Kerry S. Courneya11260849504
Robert U. Newton10975342527
Roger A. Barker10162039728
Ralph N. Martins9563035394
Wei Wang95354459660
David W. Dunstan9140337901
Peter E.D. Love9054624815
Andrew Jones8369528290
Hongqi Sun8126520354
Leon Flicker7946522669
Mark A. Jenkins7947221100
Josep M. Gasol7731322638
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202350
2022156
20211,433
20201,372
20191,213
20181,023