Showing papers by "Emory University published in 1969"
TL;DR: The results reported here indicate that women with known genital herpetic infection should be followed closely as a special group with an increased risk of developing cervical anaplastic changes.
Abstract: During a 5 1/2 year period 245 patients at Grady Memorial Hospital had cytologic evidence of an active genital herpetic infection. Cervical biopsies obtained in 98 of these patients showed a 23.7% incidence (58 cases) of cervical anaplasia including 4 cases of invasive and 12 cases of in situ squamous cell carcinoma. This is in contrast with the 1.6% overall incidence of cervical anaplasia among a control group of 245 apparently noninfected women of similar age and background and the 2.7% incidence found in the total 56418 women screened during this period. These findings suggest that either similar factors operate independently to produce both conditions or that the venereally transmitted (type 2) genital herpesvirus plays some etiologic role in precancerous and cancerous cervical lesions. Findings supporting 1 or the other theory are presented; however there is no firm conclusion which can be drawn. In either case the results reported here indicate that women with known genital herpetic infection should be followed closely as a special group with an increased risk of developing cervical anaplastic changes. (authors)
155 citations
TL;DR: This investigation has demonstrated that optimal sympathomimetic amine therapy of shock is facilitated by an analysis of hemodynamic status and responses to drug administration.
Abstract: The hemodynamic responses to isoproterenol and dopamine were investigated in 22 patients with the shock syndrome from various etiologies. Dopamine was superior to isoproterenol in seven patients with normal or low peripheral resistance. In this group of patients administration of isoproterenol was associated with unacceptably low blood pressure. Isoproterenol was superior in three patients in whom dopamine did not increase cardiac output. Both amines produced adequate clinical response in four patients, and a combination of isoproterenol and dopamine was necessary for adequate therapy in two patients. Six patients did not respond hemodynamically or clinically to either dopamine or isoproterenol. This investigation has demonstrated that optimal sympathomimetic amine therapy of shock is facilitated by an analysis of hemodynamic status and responses to drug administration.
132 citations
TL;DR: The International Encyclopedia of the Social Sciences (INES) as mentioned in this paper is the most popular encyclopedia for the social sciences and it was published between 1927 and 1933 and published in fifteen volumes between 1930 and 1935.
Abstract: On first glancing through the new International Encyclopedia of the Social Sciences' I gained the impression that it was markedly less historical in both character and content than the old Encyclopedia of the Social Sciences. Further investigation and analysis substantiated the impression. Nevertheless, the new encyclopedia is not necessarily, for that reason, less useful to economic historians. The slight difference in the wording of the titles is not the key to the difference in the tone of the two encyclopedias. If anything, the new encyclopedia is slightly less international (as measured by nationality of editors, editorial advisors, and contributors) than the old. The difference in that respect is negligible, however. David Sills, the editor, states in his introduction (1, p. xix) that the new encyclopedia is "designed to complement, not to supplant, its predecessor." In that respect it is quite successful. The old encyclopedia, prepared between 1927 and 1933 and published in fifteen volumes between 1930 and 1935, appeared at a time when the social sciences were self-consciously seeking their own identity. Psychology, for example, was then labeled as a "semisocial science," and geography was included among the sciences "with social implications." The emphasis in the older work was strongly substantive, i.e., historical. In contrast, the emphasis in the new is methodological, exemplified most notably by the inclusion of statistics, further elaborated as "theoretical statistics, the design of experiments, nonsampling errors, sample surveys, government statistics, and the use of statistical methods in social science research" (1, p. xxii) as one of the constituent social science disciplines. (The fact that W. Allen Wallis was chairman of the editorial advisory board is probably not coincidental with that emphasis.) Concretely, there are two, possibly three ways in which the new encyclopedia is less historical than the old. In the first place, the old began with two lengthy introductions, occupying almost the entirety of the first volume, devoted to "The Development of Social Thought and Institutions" from ancient times to the 1930's and "The Social Sciences as Disciplines," another country-by-country historical survey. In contrast, the International Encyclopedia has only a Foreword by Alvin Johnson, the honorary editor (who was associate-that is, executive-editor of the older work); a Preface by Wallis; and an introduction by Sills, occupying altogether only twenty pages. Secondly, the older encyclopedia included more than 4000 biographical articles devoted to historical actors as well as to notable social scientists.
111 citations
TL;DR: Stimulation of lateral and anterior hypothalamic sites in male rhesus monkeys resulted in aggressive attacks directed against other group members, which were sufficient to cause a permanent reversal of dominance.
109 citations
TL;DR: In this article, Papkoff and Samy (Biochim) used countercurrent distribution to isolate bovine pituitary luteinizing hormone (LH) subunits.
104 citations
TL;DR: In this article, the authors compared multiple measures of dominance using a total of forty-eight pigtail monkeys (Macaca nemestrina) and found that the hierarchy was remarkably stable and even the natural replacement of the alpha male produced only moderate changes in the rank order structure.
103 citations
TL;DR: None of the radiation regimens was superior to IT MTX when the following parameters were considered: duration of CNS remission; duration of existing bone marrow remission; survival from onset of meningeal leukemia; and number of CNS relapses.
101 citations
TL;DR: The notion of finite embeddability was introduced in this paper, where it was shown that an algebra A in a variety V has the finite embedding property if any finite incomplete algebra contained in A is embeddable in a finite F-algebra.
Abstract: Finite embeddability. An algebra A is residually finite if for any x # y in A, there is a homomorphism a of A onto a finite algebra such that xct # yu. For the notion of an incomplete or partial algebra in a variety, we refer to [4, 6]. We say that an algebra A in a variety V has the finite embeddability property if any finite incomplete F-algebra contained in A is embeddable in a finite F-algebra. A variety V is said to have the finite embeddability property if every algebra in V has the property. Thus, a variety V has the finite embeddability property if any finite incomplete K-algebra which is embeddable is embeddable in a finite F-algebra. We note also that a variety has the finite embeddability property if its finitely generated algebras have this property. To see this, let A be an algebra in a variety V whose finitely generated algebras have the finite embeddability property and let / be a finite incomplete algebra contained in A. Let B be the F-algebra freely generated by / . The algebra B is not necessarily a subalgebra of A but B contains / isomorphically [4; Lemma 1] and B is finitely generated. Hence, I is finitely embeddable and so V has the finite embeddability property.
87 citations
TL;DR: The present study indicated that the active site is involved in the dimerization of lysozyme and crystallographic studies indicate that glutamic acid residue 35 lies in the "cleft" of the active region and that it probably has a high pKa.
79 citations
TL;DR: An infant chimpanzee (Pan troglodytes) with clinical, behavioral, and cytogenetic features similar to those in Down's syndrome is described.
Abstract: An infant chimpanzee (Pan troglodytes) with clinical, behavioral, and cytogenetic features similar to those in Down's syndrome is described. The infant shows retarded growth rate, congenital abnormalities, retarded neurologic and postural development, epicanthus, hyperflexibility of the joints, muscle hypotonia, and trisomy of a small acrocentric chromosome.
73 citations
TL;DR: Amino acid sequences of encephalitogenic proteins from bovine cord and rabbit brain are reported and analysis of this protein and a 140-residue myelin basic protein indicates that the smaller protein is a portion of the larger encephalItogen.
Abstract: Amino acid sequences of encephalitogenic proteins from bovine cord and rabbit brain are reported. The bovine protein contains 45 residues. The rabbit protein is identical except for two isopolar substitutions, a dipeptide and amino acid deletion. Analysis of this protein and a 140-residue myelin basic protein indicates that the smaller protein is a portion of the larger encephalitogen. The larger myelin protein contains at least two encephalitogenic sites.
TL;DR: In this article, a series of rock samples with granitic composition in various stages of chemical weathering is ground in a mortar with distilled water and the pH of the slurry produced is determined, it will be evident that the pH declines as the weathering increases.
Abstract: If a series of rock samples with granitic composition in various stages of chemical weathering is ground in a mortar with distilled water and the pH of the slurry produced is determined, it will be evident that the pH declines as the weathering increases. This relationship can be made useful by plotting abrasion pH against some other index of weathering such as the percentage of clay mineral or the bulk density of the weathered rock. Factors controlling abrasion pH are the cations such as K, Na, Ca, and Mg and the amount of clay mineral present.
TL;DR: Histological evidence of healing of these grafts is presented and there was an adequate zone of attached gingiva in areas that previously had none or very little.
Abstract: Clinical success has frequently been reported with the use of various types of tissue grafts. The criteria used in judging the postoperative results successful were, (1) the area resisted a probe and (2) there was an adequate zone of attached gingiva in areas that previously had none or very little. The clinical successes reported provided the impetus for this study. This paper reviews the investigations carried out in these areas and also presents histological evidence of healing of these grafts.
TL;DR: The effect of RAMT serum on herpesvirus hominis (HVH) infection was considered of particular interest since certain clinical conditions associated with defects in the thymus-dependent cellular immune system, such as the Wiskott-Aldrich syndrome may develop severe, even fatal, HVH infections.
Abstract: Rabbit antimouse thymocyte (RAMT) serum, a potent suppressant of cell-mediated immunity (1), has been shown to affect the course of several viral infections in mice (2). The effect of RAMT serum on herpesvirus hominis (HVH) infection was considered of particular interest since certain clinical conditions associated with defects in the thymus-dependent cellular immune system, such as the Wiskott-Aldrich syndrome (3) may develop severe, even fatal, HVH infections. It was also desirable to ascertain if the effect of RAMT serum would depend on the route of HVH inoculation, since this was an important factor in the case of primary vaccinia infection in mice (4).Materials and Methods. Virus strain. Earlier studies in adult mice demonstrated that neurovirulence of HVH strains depended on their antigenic type; HVH type 2 is more virulent than HVH type 1 whether inoculated intragenitally, intramuscularly, or intracerebrally (5, 6). Since all 28 HVH strains isolated from the brain or spinal fluid of patients, other...
TL;DR: The findings suggest that, in addition to the chronically obstructed airway, a racial predilection, a defect of the central nervous system causing abnormal respiratory control, and a hyperreactive pulmonary vascular bed must also be present for the development of this unusual syndrome.
Abstract: Four cases of cor pulmonale secondary to alveolar hypoventilation from chronic upper airway obstruction (enlarged tonsils and adenoids) are presented with a review of the previously reported cases The findings suggest that, in addition to the chronically obstructed airway, a racial predilection, a defect of the central nervous system causing abnormal respiratory control, and a hyperreactive pulmonary vascular bed must also be present for the development of this unusual syndrome
TL;DR: It is found that incubation of adipose tissue slices from rabbit, hamster or rat in the homologous serum containing 10 μg/mlACTH or epinephrine causes, in association with the hormone-stimulated lipolysis, a 40–49 % decrease in medium calcium and a 150–460% increase in tissue calcium.
Abstract: Injection of 50 U adrenocorticotropin (ACTH) in rabbits produces 3 hr later a 260–680 % increase in serum FFA concentration, a 27% reduction in the concentration of calcium in serum, and a 500–1100% increase in the concentration of calcium in adipose tissue. Incubation of adipose tissue slices from rabbit, hamster or rat in the homologous serum containing 10 μg/mlACTH or epinephrine causes, in association with the hormone-stimulated lipolysis, a 40–49 % decrease in medium calcium and a 150–460% increase in tissue calcium. When the incubation medium is Krebs-Ringer buffer +bovine serum albumin instead of serum, a similar degree of lipolysis is stimulated in rabbit adipose tissue by ACTH, but no detectable redistribution of calcium from medium to tissue occurs. (Endocrinology 84: 926, 1969)
TL;DR: In this paper, an electron microscopic study was undertaken of pocks produced on the choriallantoic membrane of embryonated eggs after infection with type 1 and type 2 HVH strains.
Abstract: In view of recent recognition of the existence of two Herpesvirus hominis (HVH) types with antigenic and biological differences, an electron microscopic study was undertaken of pocks produced on the choriallantoic membrane of embryonated eggs after infection with type 1 and type 2 HVH strains. Besides the typical morphological features of herpesvirus infection noted by several investigators, it was observed that type 2 HVH also produced microtubules measuring approximately 19 nm in both nucleus and cytoplasm. Although the nature of these filamentous structures is still unclear, consideration is given in this paper to the possibility that they may represent viral structural subunits, aberrant forms or neoantigens.
TL;DR: An improved detection of activity of l-gulonolactone oxidase, which is responsible for the final oxidative step in the synthetic process of L-ascorbate from glucose in animals, was achieved using phenazine methosulfate and cyanide using cold acetone fixation.
Abstract: Histochemical detection of L-gulonolactone- phenazine methosulfate oxidoreductase activity in mammals with emphasis on vitamin C synthesis in primates
TL;DR: It is shown that mesencephalic reticular formation stimulation may modulate the excitability of neurons in HVM but it is not known whether this effect occurs as a result of reticular action upon neurons of the lateral hypothalamus or directly upon ventromedial nucleus cells.
Abstract: In animals there is abundant evidence that the portion of the hypothalamus which includes the ventromedial nucleus(HVM) plays an important role in feeding behavior, gonadotropin release, and certain types of aggressive behavior. An understanding of the afferent and efferent connections of this region would aid in studies of the mechanisms by which cells of HVM participate in these important physiological activities. Some of the afferent pathways that discharge cells in HVM have been studied by electrophysiological methods( Gloor, 1956; Sutin, 1963) and have been found to activate separate populations of cells within the nucleus (Tsubokawa & Sutin, 1963). However, these electrophysiological studies are not able to provide definitive evidence for locating the sites of synapic junction along the pathways examined. Although there is evidence that afferent pathways to the hypothalamus pass through, or synapse in, the lateral hypothalamul(Guillery, 1957; Nauta, 1958 & 1961), we have not been able to demonstrate degeneration passing to HVH following lesions in the lateral hypothalamus (Wolf & Sutin, 1966). It has been shown that mesencephalic reticular formation stimulation may modulate the excitability of neurons in HVM(Tsubokawa & Sutin, 1963) but it is not known whether this effect occurs as a result of reticular action upon neurons of the lateral hypothalamus or directly upon ventromedial nucleus cells. Although fibers ascend from the midbrain periaqueductal region and adjacent reticular formation into the posterior portion of the hypothalamic periventricular stratum(see Sutin, 1966, for review), only a small number reach the HVM(Szentlgothai et al., 1962). Scheibel and Scheibel( 1958) found that axons passing from cells in the pontine reticular formation terminate in the ventromedial hypothalamus as well as more dorsally in the thalamus. Electron microscopic observations( Szentlgothai et al., 1962) have shown few axosomatic synapses but many axodendritic synapses on HVM neurons. The course of axons leaving the HVM is even more problematic Ramon y Cajal( 1966) and Szentlgothai et al.( 1962), on the basis of Golgi preparations, describe the cells of the ventromedial nucleus as having ramifying dendrites that extend throughout virtually all of the nucleus. The axons give off numerous collaterals within the nucleus and then enter the fibrous capsule ro pass dorsally and appear to orient themselves in an anterior-posterior direction. The complexity of the neuropil in this region makes it impossible to follow the further
TL;DR: After unilateral eye removal in Erinaceus and Galago, Nauta‐gygax and Fink‐Heimer silver impregnation methods were used to study the accessory optic system.
Abstract: After unilateral eye removal in Erinaceus and Galago, Nauta-gygax and Fink-Heimer silver impregnation methods were used to study the accessory optic system. In Erinaceus the accessory optic fibers terminate contralaterally in the dorsal lateral and medial terminal nuclei of the accessory optic system; in Galago only the dorsal and lateral terminal nuclei are seen.
Hayhow's nomenclature of the accessory optic fibers in modified in such a way that they are now classified according to their terminations. The D-fibers terminate in the dorsal terminal nucleus, the L-fibers in the lateral terminal nucleus, and the M-fibers in the medial terminal nucleus. Accordingly, D-, L- and M-fibers are found in Erinaceus, while only D- and L-fibers are present in Galago.
As in the two monkey species recently studied, but contrasting sharply with the findings in all non-primate mammals, the M-fibers and the medial terminal nucleus are absent in Galago. It is hypothetized that the accessory optic system is similarly reduced in all other primates.
No retinal fibers terminate in the preoptic region, lamina terminalis, hypothalamus, subthalamic nucleus or substantia nigra.
TL;DR: In Hiroshima and Nagasaki chronic lymphocytic leukemia is rare in comparison to the United States, and no patient with this disorder was identified among the residents of Hiroshima City during a 20 year period of study.
TL;DR: The results reported here indicate that women with known genital herpetic infection should be followed closely as a special group with an increased risk of developing cervical anaplastic changes and that the venereally transmitted herpesvirus plays some etiologic role in precancerous and cancerous cervical lesions.
Abstract: During a 5 1/2 year period 245 patients at Grady Memorial Hospital had cytologic evidence of an active genital herpetic infection. Cervical biopsies obtained in 98 of these patients showed a 23.7% incidence (58 cases) of cervical anaplasia including 4 cases of invasive and 12 cases of in situ squamous cell carcinoma. This is in contrast with the 1.6% overall incidence of cervical anaplasia among a control group of 245 apparently noninfected women of similar age and background and the 2.7% incidence found in the total 56418 women screened during this period. These findings suggest that either similar factors operate independently to produce both conditions or that the venereally transmitted (type 2) genital herpesvirus plays some etiologic role in precancerous and cancerous cervical lesions. Findings supporting 1 or the other theory are presented; however there is no firm conclusion which can be drawn. In either case the results reported here indicate that women with known genital herpetic infection should be followed closely as a special group with an increased risk of developing cervical anaplastic changes. (authors)
TL;DR: The data show that, in all 15 instances tested, the free fat cells from the same rat, hamster or guinea pig were incubated with ACTH and the effect of the incubation on the hormone’s lipolytic activity was measured.
Abstract: The adipose tissues of rat, hamster and guinea pig are known to differ from each other in capacity to respond to the lipolytic action of adrenocorticotropin (ACTH), β-melanocyte-stimulating hormone (β-MSH), thyroidstimulating hormone (TSH), glucagon and epinephrine, and in capacity of the homogenized tissue, to destroy the lipolytic activity of ACTH and other lipolytic pituitary peptides. In order to learn whether these species differences reside in the fat cells, or in other components of the adipose tissue, (a) adipose tissue slices and free fat cells (prepared by the collagenase technique of Rodbell) from the same rat, hamster or guinea pig were incubated with ACTH, β-MSH, TSH, glucagon or epinephrine, and the lipolytic response was measured; (b) aqueous homogenates of adipose tissue and free fat cells from the same rat or hamster were incubated with ACTH and the effect of the incubation on the hormone’s lipolytic activity was measured. The data show that, in all 15 instances tested, the free fat cells...