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Institution

Emory University

EducationAtlanta, Georgia, United States
About: Emory University is a education organization based out in Atlanta, Georgia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 51959 authors who have published 122469 publications receiving 6010698 citations.


Papers
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Journal ArticleDOI
TL;DR: The Solitaire Flow Restoration Device achieved substantially better angiographic, safety, and clinical outcomes than did the Merci Retrieval System and might be a future treatment of choice for endovascular recanalisation in acute ischaemic stroke.

1,217 citations

Journal ArticleDOI
TL;DR: Recommendations were developed based on the literature using standardized assessment methods from the American Heart Association and Grading of Recommendations Assessment, Development, and Evaluation systems, as well as expert opinion when sufficient data were lacking.
Abstract: Status epilepticus (SE) treatment strategies vary substantially from one institution to another due to the lack of data to support one treatment over another. To provide guidance for the acute treatment of SE in critically ill patients, the Neurocritical Care Society organized a writing committee to evaluate the literature and develop an evidence-based and expert consensus practice guideline. Literature searches were conducted using PubMed and studies meeting the criteria established by the writing committee were evaluated. Recommendations were developed based on the literature using standardized assessment methods from the American Heart Association and Grading of Recommendations Assessment, Develop- ment, and Evaluation systems, as well as expert opinion when sufficient data were lacking.

1,215 citations

Journal ArticleDOI
TL;DR: The author reveals evidence for OXPHOS DEFECTS in COMMON DEGENERATIVE DISEASes in NUCLEAR-CYTOPLASMIC INTERACTIONS and provides evidence for the importance of knowing the carrier and removal status of canine coronavirus.
Abstract: INTRODUCTION . . _ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 175 THE HUMAN MITOCHONDRIAL DNA AND OXIDATIVE PHOSPHORYLATION 1176 Mitochondrial Biogenesis ... 1 176 Mitochondrial OXPHOS Complexes and their Synthesis 1 178 Developmental Regulation of Nuclear OXPHOS Genes 1179 Mitochondrial DNA Genetics 1 1 8 1 MITOCHONDRIAL DNA MUTATIONS AND DISEASE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 183 Missense Mutations 1184 Biogenesis Mutations 1 1 88 Insertion-Deletion Mutations . 1 192 Copy Number Mutations 1 195 DEFECTS IN NUCLEAR-CYTOPLASMIC INTERACTIONS . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 1 195 THE PROGRESSION OF OXPHOS DISEASES AND AGING 1 196 EVIDENCE FOR OXPHOS DEFECTS IN COMMON DEGENERATIVE DISEASES . . ... . . . . . . . . . .... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . 1201 METABOLIC AND GENETIC THERAPY OF OXPHOS DEFECTS 1206

1,210 citations

Journal ArticleDOI
TL;DR: Patients with mildly abnormal scans after exercise stress are at low risk for cardiac death but intermediate risk for nonfatal myocardial infarction and thus may benefit from a noninvasive strategy and may not require invasive management.
Abstract: Background—The incremental prognostic value of stress single photon emission computed tomography (SPECT) for the prediction of cardiac death as an individual end point and the implications for risk stratification are undefined. Methods and Results—We identified 5183 consecutive patients who underwent stress/rest SPECT and were followed up for the occurrence of cardiac death or myocardial infarction. Over a mean follow up of 642±226 days, 119 cardiac deaths and 158 myocardial infarctions occurred (3.0% cardiac death rate, 2.3% myocardial infarction rate). Patients with normal scans were at low risk (≤0.5%/y), and rates of both outcomes increased significantly with worsening scan abnormalities. Patients who underwent exercise stress and had mildly abnormal scans had low rates of cardiac death but higher rates of myocardial infarction (0.7%/y versus 2.6%/y; P<.05). After adjustment for prescan information, scan results provided incremental prognostic value toward the prediction of cardiac death. The identifi...

1,209 citations

Journal ArticleDOI
TL;DR: The results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 × 10−8) and suggest priority targets for study in other auto-immune disorders.
Abstract: Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases and 1,436 controls of European ancestry. We followed up 21 promising SNPs in 5,048 psoriasis cases and 5,041 controls. Our results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 x 10(-8)). Loci with confirmed association include HLA-C, three genes involved in IL-23 signaling (IL23A, IL23R, IL12B), two genes that act downstream of TNF-alpha and regulate NF-kappaB signaling (TNIP1, TNFAIP3) and two genes involved in the modulation of Th2 immune responses (IL4, IL13). Although the proteins encoded in these loci are known to interact biologically, we found no evidence for epistasis between associated SNPs. Our results expand the catalog of genetic loci implicated in psoriasis susceptibility and suggest priority targets for study in other auto-immune disorders.

1,207 citations


Authors

Showing all 52622 results

NameH-indexPapersCitations
Younan Xia216943175757
Eric J. Topol1931373151025
Bernard Rosner1901162147661
Paul G. Richardson1831533155912
Peter W.F. Wilson181680139852
Dennis S. Charney179802122408
Joseph Biederman1791012117440
Kenneth C. Anderson1781138126072
David A. Weitz1781038114182
Lei Jiang1702244135205
William J. Sandborn1621317108564
Stephen J. Elledge162406112878
Ali H. Mokdad156634160599
Michael Tomasello15579793361
Don W. Cleveland15244484737
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023195
20221,123
20218,692
20208,001
20197,033
20186,326