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Institution

ETH Zurich

EducationZurich, Switzerland
About: ETH Zurich is a education organization based out in Zurich, Switzerland. It is known for research contribution in the topics: Population & Galaxy. The organization has 48393 authors who have published 122408 publications receiving 5111383 citations. The organization is also known as: Swiss Federal Institute of Technology in Zurich & Eidgenössische Technische Hochschule Zürich.
Topics: Population, Galaxy, Laser, Catalysis, Climate change


Papers
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Journal ArticleDOI
28 Sep 2007-Science
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
Abstract: Fluorine substituents have become a widespread and important drug component, their introduction facilitated by the development of safe and selective fluorinating agents. Organofluorine affects nearly all physical and adsorption, distribution, metabolism, and excretion properties of a lead compound. Its inductive effects are relatively well understood, enhancing bioavailability, for example, by reducing the basicity of neighboring amines. In contrast, exploration of the specific influence of carbon-fluorine single bonds on docking interactions, whether through direct contact with the protein or through stereoelectronic effects on molecular conformation of the drug, has only recently begun. Here, we review experimental progress in this vein and add complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank.

4,906 citations

Journal ArticleDOI
TL;DR: This paper provides a systematic comparison of various evolutionary approaches to multiobjective optimization using six carefully chosen test functions and shows that elitism is shown to be an important factor for improving evolutionary multiobjectives search.
Abstract: In this paper, we provide a systematic comparison of various evolutionary approaches to multiobjective optimization using six carefully chosen test functions. Each test function involves a particular feature that is known to cause difficulty in the evolutionary optimization process, mainly in converging to the Pareto-optimal front (e.g., multimodality and deception). By investigating these different problem features separately, it is possible to predict the kind of problems to which a certain technique is or is not well suited. However, in contrast to what was suspected beforehand, the experimental results indicate a hierarchy of the algorithms under consideration. Furthermore, the emerging effects are evidence that the suggested test functions provide sufficient complexity to compare multiobjective optimizers. Finally, elitism is shown to be an important factor for improving evolutionary multiobjective search.

4,867 citations

Journal ArticleDOI
TL;DR: In this paper, the results of a study to develop natural zircon geochemical standards for calibrating the U-(Th)-Pb geochronometer and Hf isotopic analyses are reported.
Abstract: We report here the results of a study to develop natural zircon geochemical standards for calibrating the U-(Th)-Pb geochronometer and Hf isotopic analyses. Additional data were also collected for the major, minor and trace element contents of the three selected sample sets. A total of five large zircon grains (masses between 0.5 and 238 g) were selected for this study, representing three different suites of zircons with ages of 1065 Ma, 2.5 Ma and 0.9 Ma. Geochemical laboratories can obtain these materials by contacting Geostandards Newsletter.

4,845 citations

Journal ArticleDOI
TL;DR: Food in the Anthropocene : the EAT-Lancet Commission on healthy diets from sustainable food systems focuses on meat, fish, vegetables and fruit as sources of protein.

4,710 citations

Journal ArticleDOI
03 Jan 2002-Nature
TL;DR: This work observes a quantum phase transition in a Bose–Einstein condensate with repulsive interactions, held in a three-dimensional optical lattice potential, and can induce reversible changes between the two ground states of the system.
Abstract: For a system at a temperature of absolute zero, all thermal fluctuations are frozen out, while quantum fluctuations prevail. These microscopic quantum fluctuations can induce a macroscopic phase transition in the ground state of a many-body system when the relative strength of two competing energy terms is varied across a critical value. Here we observe such a quantum phase transition in a Bose-Einstein condensate with repulsive interactions, held in a three-dimensional optical lattice potential. As the potential depth of the lattice is increased, a transition is observed from a superfluid to a Mott insulator phase. In the superfluid phase, each atom is spread out over the entire lattice, with long-range phase coherence. But in the insulating phase, exact numbers of atoms are localized at individual lattice sites, with no phase coherence across the lattice; this phase is characterized by a gap in the excitation spectrum. We can induce reversible changes between the two ground states of the system.

4,467 citations


Authors

Showing all 49062 results

NameH-indexPapersCitations
Ralph Weissleder1841160142508
Ruedi Aebersold182879141881
David L. Kaplan1771944146082
Andrea Bocci1722402176461
Richard H. Friend1691182140032
Lorenzo Bianchini1521516106970
David D'Enterria1501592116210
Andreas Pfeiffer1491756131080
Bernhard Schölkopf1481092149492
Martin J. Blaser147820104104
Sebastian Thrun14643498124
Antonio Lanzavecchia145408100065
Christoph Grab1441359144174
Kurt Wüthrich143739103253
Maurizio Pierini1431782104406
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023700
20221,316
20218,530
20208,660
20197,883
20187,455