Institution
ETH Zurich
Education•Zurich, Switzerland•
About: ETH Zurich is a education organization based out in Zurich, Switzerland. It is known for research contribution in the topics: Population & Galaxy. The organization has 48393 authors who have published 122408 publications receiving 5111383 citations. The organization is also known as: Swiss Federal Institute of Technology in Zurich & Eidgenössische Technische Hochschule Zürich.
Topics: Population, Galaxy, Laser, Catalysis, Climate change
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
Abstract: Fluorine substituents have become a widespread and important drug component, their introduction facilitated by the development of safe and selective fluorinating agents. Organofluorine affects nearly all physical and adsorption, distribution, metabolism, and excretion properties of a lead compound. Its inductive effects are relatively well understood, enhancing bioavailability, for example, by reducing the basicity of neighboring amines. In contrast, exploration of the specific influence of carbon-fluorine single bonds on docking interactions, whether through direct contact with the protein or through stereoelectronic effects on molecular conformation of the drug, has only recently begun. Here, we review experimental progress in this vein and add complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank.
4,906 citations
••
TL;DR: This paper provides a systematic comparison of various evolutionary approaches to multiobjective optimization using six carefully chosen test functions and shows that elitism is shown to be an important factor for improving evolutionary multiobjectives search.
Abstract: In this paper, we provide a systematic comparison of various evolutionary approaches to multiobjective optimization using six carefully chosen test functions. Each test function involves a particular feature that is known to cause difficulty in the evolutionary optimization process, mainly in converging to the Pareto-optimal front (e.g., multimodality and deception). By investigating these different problem features separately, it is possible to predict the kind of problems to which a certain technique is or is not well suited. However, in contrast to what was suspected beforehand, the experimental results indicate a hierarchy of the algorithms under consideration. Furthermore, the emerging effects are evidence that the suggested test functions provide sufficient complexity to compare multiobjective optimizers. Finally, elitism is shown to be an important factor for improving evolutionary multiobjective search.
4,867 citations
••
TL;DR: In this paper, the results of a study to develop natural zircon geochemical standards for calibrating the U-(Th)-Pb geochronometer and Hf isotopic analyses are reported.
Abstract: We report here the results of a study to develop natural zircon geochemical standards for calibrating the U-(Th)-Pb geochronometer and Hf isotopic analyses. Additional data were also collected for the major, minor and trace element contents of the three selected sample sets. A total of five large zircon grains (masses between 0.5 and 238 g) were selected for this study, representing three different suites of zircons with ages of 1065 Ma, 2.5 Ma and 0.9 Ma. Geochemical laboratories can obtain these materials by contacting Geostandards Newsletter.
4,845 citations
••
Harvard University1, Potsdam Institute for Climate Impact Research2, Stockholm Resilience Centre3, University of Oxford4, City University London5, Chatham House6, World Wide Fund for Nature7, Environmental Change Institute8, University of Minnesota9, University of California, Santa Barbara10, CGIAR11, Johns Hopkins University12, American University of Beirut13, Wageningen University and Research Centre14, Institute for Health Metrics and Evaluation15, Indian Institute of Technology Kanpur16, ETH Zurich17, Commonwealth Scientific and Industrial Research Organisation18, University of Indonesia19, World Health Organization20, Food and Agriculture Organization21, International Food Policy Research Institute22, Royal Swedish Academy of Sciences23, University of Auckland24, Public Health Foundation of India25, Centre for Science and Environment26
TL;DR: Food in the Anthropocene : the EAT-Lancet Commission on healthy diets from sustainable food systems focuses on meat, fish, vegetables and fruit as sources of protein.
4,710 citations
••
TL;DR: This work observes a quantum phase transition in a Bose–Einstein condensate with repulsive interactions, held in a three-dimensional optical lattice potential, and can induce reversible changes between the two ground states of the system.
Abstract: For a system at a temperature of absolute zero, all thermal fluctuations are frozen out, while quantum fluctuations prevail. These microscopic quantum fluctuations can induce a macroscopic phase transition in the ground state of a many-body system when the relative strength of two competing energy terms is varied across a critical value. Here we observe such a quantum phase transition in a Bose-Einstein condensate with repulsive interactions, held in a three-dimensional optical lattice potential. As the potential depth of the lattice is increased, a transition is observed from a superfluid to a Mott insulator phase. In the superfluid phase, each atom is spread out over the entire lattice, with long-range phase coherence. But in the insulating phase, exact numbers of atoms are localized at individual lattice sites, with no phase coherence across the lattice; this phase is characterized by a gap in the excitation spectrum. We can induce reversible changes between the two ground states of the system.
4,467 citations
Authors
Showing all 49062 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ralph Weissleder | 184 | 1160 | 142508 |
Ruedi Aebersold | 182 | 879 | 141881 |
David L. Kaplan | 177 | 1944 | 146082 |
Andrea Bocci | 172 | 2402 | 176461 |
Richard H. Friend | 169 | 1182 | 140032 |
Lorenzo Bianchini | 152 | 1516 | 106970 |
David D'Enterria | 150 | 1592 | 116210 |
Andreas Pfeiffer | 149 | 1756 | 131080 |
Bernhard Schölkopf | 148 | 1092 | 149492 |
Martin J. Blaser | 147 | 820 | 104104 |
Sebastian Thrun | 146 | 434 | 98124 |
Antonio Lanzavecchia | 145 | 408 | 100065 |
Christoph Grab | 144 | 1359 | 144174 |
Kurt Wüthrich | 143 | 739 | 103253 |
Maurizio Pierini | 143 | 1782 | 104406 |