Institution
Eulji University
Education•Daejeon, South Korea•
About: Eulji University is a education organization based out in Daejeon, South Korea. It is known for research contribution in the topics: Population & Stroke. The organization has 4066 authors who have published 6349 publications receiving 89831 citations.
Topics: Population, Stroke, Diabetes mellitus, Cancer, Cohort
Papers published on a yearly basis
Papers
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Clotilde Théry1, Kenneth W. Witwer2, Elena Aikawa3, María José Alcaraz4 +414 more•Institutions (209)
TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.
Abstract: The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
5,988 citations
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TL;DR: Shape, margin, echogenicity, and presence of calcification are helpful criteria for the discrimination of malignant from benign nodules; the diagnostic accuracy of US criteria is dependent on tumor size.
Abstract: Purpose: To retrospectively evaluate the diagnostic accuracy of ultrasonographic (US) criteria for the depiction of benign and malignant thyroid nodules by using tissue diagnosis as the reference standard. Materials and Methods: This study had institutional review board approval, and informed consent was waived. From January 2003 through June 2003, 8024 consecutive patients had undergone thyroid US at nine affiliated hospitals. A total of 831 patients (716 women, 115 men; mean age, 49.5 years ± 13.8 [standard deviation]) with 849 nodules (360 malignant, 489 benign) that were diagnosed at surgery or biopsy were included in this study. Three radiologists retrospectively evaluated the following characteristics on US images: nodule size, presence of spongiform appearance, shape, margin, echotexture, echogenicity, and presence of microcalcification, macrocalcification, or rim calcification. A χ2 test and multiple regression analysis were performed. Sensitivity, specificity, and positive and negative predictive...
956 citations
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TL;DR: The structures of these proteins account for how the immune system differentiates LPS molecules from structurally similar host molecules and provide insights useful for discovery of anti-sepsis drugs.
Abstract: Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. Minute amounts of LPS released from infecting pathogens can initiate potent innate immune responses that prime the immune system against further infection. However, when the LPS response is not properly controlled it can lead to fatal septic shock syndrome. The common structural pattern of LPS in diverse bacterial species is recognized by a cascade of LPS receptors and accessory proteins, LPS binding protein (LBP), CD14 and the Toll-like receptor4 (TLR4)–MD-2 complex. The structures of these proteins account for how our immune system differentiates LPS molecules from structurally similar host molecules. They also provide insights useful for discovery of anti-sepsis drugs. In this review, we summarize these structures and describe the structural basis of LPS recognition by LPS receptors and accessory proteins.
763 citations
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University of Malaya1, Central Food Technological Research Institute2, Thailand National Science and Technology Development Agency3, Mahidol University4, Korea Research Institute of Bioscience and Biotechnology5, University of the Philippines6, Academia Sinica7, Agency for Science, Technology and Research8, Peking Union Medical College9, National Institute of Advanced Industrial Science and Technology10, Universiti Sains Malaysia11, Chinese National Human Genome Center12, Tokai University13, Fudan University14, Chiang Mai University15, Thermo Fisher Scientific16, Soongsil University17, Eulji University18, University of Tokyo19, National University of Singapore20, Indian Statistical Institute21, Eijkman Institute for Molecular Biology22, Nanyang Technological University23, University of the Ryukyus24, Health Sciences University of Hokkaido25, Monash University Malaysia Campus26, National Institutes of Health27
TL;DR: The results suggest that there may have been a single major migration of people into Asia and a subsequent south-to-north migration across the continent, and that genetic ancestry is strongly correlated with linguistic affiliations as well as geography.
Abstract: Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
545 citations
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TL;DR: It is suggested that AMPK is a novel and critical component of both inhibition of adipocyte differentiation and apoptosis of mature adipocytes by genistein or EGCG or capsaicin further implying AMPK as a prime target of obesity control.
468 citations
Authors
Showing all 4076 results
Name | H-index | Papers | Citations |
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Sang Cheol Bae | 80 | 582 | 28575 |
Daijin Kim | 76 | 695 | 25017 |
Myung-Hwan Kim | 74 | 519 | 19078 |
Sun Young Rha | 65 | 581 | 18356 |
Hyun Cheol Chung | 63 | 499 | 26405 |
Won Ho Kim | 61 | 704 | 18779 |
Dong Wan Seo | 58 | 341 | 10794 |
Sung Koo Lee | 58 | 319 | 10198 |
Hee Jin Kim | 56 | 1121 | 16633 |
Dong-Wook Kim | 55 | 474 | 17926 |
Beom Joon Kim | 54 | 872 | 13628 |
Hyun-Jin Kim | 52 | 769 | 13729 |
Shin Wook Kang | 51 | 441 | 9256 |
Sang Soo Lee | 50 | 233 | 7346 |
Miyong T. Kim | 47 | 163 | 5533 |