Institution
European Institute
About: European Institute is a based out in . It is known for research contribution in the topics: European union & Population. The organization has 1659 authors who have published 2114 publications receiving 66190 citations. The organization is also known as: The European Institute.
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University Hospital Bonn1, University of California, Riverside2, Harvard University3, Case Western Reserve University4, University of Illinois at Chicago5, European Institute6, Stanford University7, VA Palo Alto Healthcare System8, Spanish National Research Council9, Cleveland Clinic Lerner Research Institute10, Hong Kong University of Science and Technology11, University of California, Los Angeles12, University of Southern Denmark13, University of Cambridge14, Ikerbasque15, University of the Basque Country16, University of Manchester17, RIKEN Brain Science Institute18, University of Eastern Finland19, University of Massachusetts Medical School20, University of Bonn21, Center of Advanced European Studies and Research22, University of Southern California23, University of South Florida24, Duke University25, Southampton General Hospital26, University of Southampton27, Moorgreen Hospital28, Louisiana State University29, Imperial College London30, Centre national de la recherche scientifique31, Karolinska Institutet32, Max Planck Society33, University of Tübingen34, University of Groningen35, University of Colorado Denver36, Douglas Mental Health University Institute37
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Abstract: Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease.
3,947 citations
TL;DR: The purpose of this paper is to explain why task uncertainty is related to organizational form, and why the cognitive limits theory of Herbert Simon was the guiding influence.
Abstract: The purpose of this paper is to explain why task uncertainty is related to organizational form. In so doing the cognitive limits theory of Herbert Simon was the guiding influence. As the consequences of cognitive limits were traced through the framework various organization design strategies were articulated. The framework provides a basis for integrating organizational interventions, such as information systems and group problem solving, which have been treated separately before.
1,974 citations
TL;DR: The results suggest that gene therapy in combination with bone marrow conditioning can be successfully used to treat inherited diseases affecting the myeloid compartment such as CGD.
Abstract: Gene transfer into hematopoietic stem cells has been used successfully for correcting lymphoid but not myeloid immunodeficiencies. Here we report on two adults who received gene therapy after nonmyeloablative bone marrow conditioning for the treatment of X-linked chronic granulomatous disease (X-CGD), a primary immunodeficiency caused by a defect in the oxidative antimicrobial activity of phagocytes resulting from mutations in gp91(phox). We detected substantial gene transfer in both individuals' neutrophils that lead to a large number of functionally corrected phagocytes and notable clinical improvement. Large-scale retroviral integration site-distribution analysis showed activating insertions in MDS1-EVI1, PRDM16 or SETBP1 that had influenced regulation of long-term hematopoiesis by expanding gene-corrected myelopoiesis three- to four-fold in both individuals. Although insertional influences have probably reinforced the therapeutic efficacy in this trial, our results suggest that gene therapy in combination with bone marrow conditioning can be successfully used to treat inherited diseases affecting the myeloid compartment such as CGD.
1,172 citations
952 citations
TL;DR: This study shows that bypassing a short segment of proximal intestine directly ameliorates type 2 diabetes, independently of effects on food intake, body weight, malabsorption, or nutrient delivery to the hindgut.
Abstract: Summary Background Data:Most patients who undergo Roux-en-Y gastric bypass (RYGB) experience rapid resolution of type 2 diabetes. Prior studies indicate that this results from more than gastric restriction and weight loss, implicating the rearranged intestine as a primary mediator. It is unclear, ho
897 citations
Authors
Showing all 1659 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Philippe Froguel | 166 | 820 | 118816 |
| Janet M. Thornton | 130 | 539 | 105144 |
| Giuseppe Viale | 123 | 740 | 72799 |
| Patrick Maisonneuve | 118 | 582 | 53363 |
| Pier Giuseppe Pelicci | 116 | 574 | 58240 |
| Rui L. Reis | 115 | 1608 | 63223 |
| Maria Rescigno | 109 | 442 | 55411 |
| Peter Boyle | 103 | 535 | 49474 |
| João F. Mano | 97 | 822 | 36401 |
| Martin Pumera | 87 | 768 | 37404 |
| Hervé Tilly | 86 | 479 | 30321 |
| Hubert Vaudry | 80 | 975 | 34350 |
| Luk N. Van Wassenhove | 78 | 322 | 29163 |
| Marco Colleoni | 75 | 401 | 24053 |
| Jean-Louis Mergny | 75 | 301 | 19146 |