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Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto
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About: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto is a based out in . It is known for research contribution in the topics: Population & Genus. The organization has 2143 authors who have published 3674 publications receiving 71071 citations. The organization is also known as: FFCLRP & FFCLRP-USP.
Topics: Population, Genus, Catalysis, Ruthenium, Elevated plus maze
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TL;DR: A potential method to identify citrus greening at an early stage of the disease (first month), prior to the onset of visual symptoms at confidence level of 95%.
40 citations
TL;DR: It is reported that Na+ binding at the activating site leads to cooperative, heterotropic interactions that are insensitive to K+.
40 citations
TL;DR: IL-18 -607(*)A and TNF-α (-238A and -308A) alleles may confer susceptibility to HCC, while IL-18 (*)C and -137(*)C alleles more severe disease.
39 citations
TL;DR: The ΔsitA strain was avirulent in a murine model of invasive pulmonary aspergillosis and induces an augmented tumor necrosis factor alpha (TNF-α) response in mouse macrophages, stressing the importance of A. fumigatus SitA as a possible modulator of PkcA/MpkA activity and its involvement in the cell wall integrity pathway.
Abstract: Aspergillus fumigatus is an opportunistic pathogenic fungus able to infect immunocompromised patients, eventually causing disseminated infections that are difficult to control and lead to high mortality rates. It is important to understand how the signaling pathways that regulate these factors involved in virulence are orchestrated. Protein phosphatases are central to numerous signal transduction pathways. Here, we characterize the A. fumigatus protein phosphatase 2A SitA, the Saccharomyces cerevisiae Sit4p homologue. The sitA gene is not an essential gene, and we were able to construct an A. fumigatus null mutant. The ΔsitA strain had decreased MpkA phosphorylation levels, was more sensitive to cell wall-damaging agents, had increased β-(1,3)-glucan and chitin, was impaired in biofilm formation, and had decreased protein kinase C activity. The ΔsitA strain is more sensitive to several metals and ions, such as MnCl2, CaCl2, and LiCl, but it is more resistant to ZnSO4. The ΔsitA strain was avirulent in a murine model of invasive pulmonary aspergillosis and induces an augmented tumor necrosis factor alpha (TNF-α) response in mouse macrophages. These results stress the importance of A. fumigatus SitA as a possible modulator of PkcA/MpkA activity and its involvement in the cell wall integrity pathway.
39 citations
TL;DR: Oxygenation is an important parameter involved in the design and operation of mixing-sparging bioreactors and it can be analyzed by means of the oxygen mass transfer coefficient (kLa), in attempts to optimize and compare the activities of extracellular xylanase and β-xylosidase synthesized by the fungus Aspergillus niger van Tieghem.
39 citations
Authors
Showing all 2195 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Jon Lloyd | 80 | 230 | 30995 |
| Peter C. Ford | 74 | 495 | 20821 |
| Frederico Guilherme Graeff | 60 | 183 | 12209 |
| Marcus Lira Brandão | 54 | 243 | 9248 |
| David W. Roubik | 54 | 177 | 10070 |
| Richard J. Ward | 53 | 242 | 9502 |
| Juan Cornejo | 49 | 147 | 6478 |
| Norberto Peporine Lopes | 47 | 457 | 12031 |
| Carlos Alemán | 47 | 634 | 11349 |
| Klaus Hartfelder | 45 | 150 | 7708 |
| Valtencir Zucolotto | 45 | 212 | 6253 |
| Rosane Marina Peralta | 44 | 212 | 5701 |
| Antonio Claudio Tedesco | 44 | 307 | 6778 |
| Roberto M. Torresi | 44 | 213 | 5822 |
| Zilá Luz Paulino Simões | 43 | 113 | 8020 |