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Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto

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About: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto is a based out in . It is known for research contribution in the topics: Population & Genus. The organization has 2143 authors who have published 3674 publications receiving 71071 citations. The organization is also known as: FFCLRP & FFCLRP-USP.


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Journal ArticleDOI
TL;DR: Results indicate that PLGA MP could be a promising delivery system for psoralen in connection with ultraviolet irradiation therapy (PUVA) and the intracellular distribution and cellular uptake of the drug by using an encapsulation technique for therapeutic optimization.
Abstract: Here we describe the application of microparticles (MPs) for the delivery and release of the drug a benzopsoralen. We also evaluated the intracellular distribution and cellular uptake of the drug by using an encapsulation technique for therapeutic optimization. MPs containing the compound 3-ethoxycarbonyl-2H-benzofuro[3,2-f]-1-benzopyran-2-one (psoralen A) were prepared by the solvent evaporation technique, and parameters such as particle size, drug encapsulation efficiency, effect of the encapsulation process on the drug's photochemistry, zeta potential, external morphology, and in vitro release behavior were evaluated. The intracellular distribution of MPs as well as their uptake by tissues were monitored. Size distribution studies using dynamic ligh scattering and scanning electron microscopy revealed that the MPs are spherical in shape with a diameter of 1.4 micro m. They present low tendency toward aggregation, as confirmed by their zeta potential (+10.6 mV). The loading efficiency obtained was 75%. As a consequence of the extremely low diffusivity of the drug in aqueous medium, the drug release profile of the MPs in saline phosphate buffer (pH 7.4) was much slower than that obtained in the biological environment. Among the population of peritoneal phagocytic cells, only macrophages were able to phagocytose poly-d,l-lactic-co-glycolic acid (PLGA) MP. The use of psoralen A in association with ultraviolet light (360 nm) revealed morphological characteristics of cell damage such as cytoplasmic vesiculation, mitochondria condensation, and swelling of both the granular endoplasmatic reticulum and the nuclear membrane. These results indicate that PLGA MP could be a promising delivery system for psoralen in connection with ultraviolet irradiation therapy (PUVA).

27 citations

Journal ArticleDOI
TL;DR: Flexible coatings with dual capabilities for remote real-time temperature sensing and photothermal conversion have a huge potential in the field of advanced thermal actuated optoelectronic applicat...
Abstract: Flexible coatings with dual capabilities for remote real-time temperature sensing and photothermal conversion have a huge potential in the field of advanced thermal actuated optoelectronic applicat...

27 citations

Journal ArticleDOI
TL;DR: In this paper, thin films of aluminium-doped zinc oxide have been formed on glass using an inorganic sol-gel route and the dip-coating process and thermal analysis was used to investigate the chemical processes during firing of the sols.

26 citations

Journal ArticleDOI
TL;DR: FeFeTFPPCl [5,10,15,20-tetrakis(pentafluorophenyl)porphyrin iron(III) chloride] has been covalently supported on two series of previously aminated phyllosilicates, Tal x (natural) and Sil x (synthesized through sol/gel process), where x (=1−3) represents the length of the organic chain binding the ironporphrin to the support as mentioned in this paper.
Abstract: FeTFPPCl [5,10,15,20-tetrakis(pentafluorophenyl)porphyrin iron(III) chloride] has been covalently supported on two series of previously aminated phyllosilicates, Tal x (natural) and Sil x (synthesized through sol/gel process), where x (=1–3) represents the length of the organic chain (“arms”) binding the ironporphyrin to the support These systems have been characterized (UV-Vis, IR and EPR) and used as catalysts for the oxidation of alkanes and alkenes by iodosylbenzene and hydrogen peroxide All systems proved to be efficient catalysts for cyclohexane hydroxylation and alkene epoxidation with both oxidants FeTal x are better catalysts than FeSil x for all the investigated substrates The intermediate “arms” of FeTal2 have been the most adequate since they are not short enough to maintain the ironporphyrin near the polar support or long enough to favor axial bis-coordination of the free amino group to the iron center Protection of the excess NH 2 groups through acetylation was essential to prevent such bis-coordination and improve product yields Surprisingly, FeTal x systems have proved better catalysts for such hydrocarbon oxidations with hydrogen peroxide than the homogeneous iron porphyrin

26 citations

Journal ArticleDOI
TL;DR: In this article, a set of isatin-Schiff base copper(II) and related complexes, 1-12, have shown significant pro-apoptotic activity toward diverse tumor cells.
Abstract: Herein, we report results of calculations based on density functional theory (BP86/TZVP) of a set of isatin-Schiff base copper(II) and related complexes, 1-12, that have shown significant pro-apoptotic activity toward diverse tumor cells. The interaction of the copper(II) cation with different ligands has been investigated at the same level of theory. The strength and character of the Cu(II)-L bonding was characterized by metal-ligand bond lengths, vibrational frequencies, binding energies, ligand deformation energies, and natural population analysis. The metal-ligand bonding situation was also characterized by using two complementary topological approaches, the quantum theory of atoms-in-molecules (QTAIM) and the electron localization function (ELF). The calculated electronic g-tensor and hyperfine coupling constants present significant agreement with the EPR experimental data. The calculated parameters pointed to complex 10 as the most stable among the isatin-Schiff base copper(II) species, in good agreement with experimental data that indicate this complex as the most reactive in the series. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2012

26 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20233
202291
2021245
2020248
2019234
2018245