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Institution

Federal University of Mato Grosso do Sul

EducationCampo Grande, Brazil
About: Federal University of Mato Grosso do Sul is a education organization based out in Campo Grande, Brazil. It is known for research contribution in the topics: Population & Species richness. The organization has 6903 authors who have published 9030 publications receiving 78977 citations. The organization is also known as: UFMS & Federal University of Mato Grosso do Sul.


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Journal ArticleDOI
Mingxun Wang1, Jeremy Carver1, Vanessa V. Phelan2, Laura M. Sanchez2, Neha Garg2, Yao Peng1, Don D. Nguyen1, Jeramie D. Watrous2, Clifford A. Kapono1, Tal Luzzatto-Knaan2, Carla Porto2, Amina Bouslimani2, Alexey V. Melnik2, Michael J. Meehan2, Wei-Ting Liu3, Max Crüsemann4, Paul D. Boudreau4, Eduardo Esquenazi, Mario Sandoval-Calderón5, Roland D. Kersten6, Laura A. Pace2, Robert A. Quinn7, Katherine R. Duncan8, Cheng-Chih Hsu1, Dimitrios J. Floros1, Ronnie G. Gavilan, Karin Kleigrewe4, Trent R. Northen9, Rachel J. Dutton10, Delphine Parrot11, Erin E. Carlson12, Bertrand Aigle13, Charlotte Frydenlund Michelsen14, Lars Jelsbak14, Christian Sohlenkamp5, Pavel A. Pevzner1, Anna Edlund15, Anna Edlund16, Jeffrey S. McLean15, Jeffrey S. McLean17, Jörn Piel18, Brian T. Murphy19, Lena Gerwick4, Chih-Chuang Liaw20, Yu-Liang Yang21, Hans-Ulrich Humpf22, Maria Maansson14, Robert A. Keyzers23, Amy C. Sims24, Andrew R. Johnson25, Ashley M. Sidebottom25, Brian E. Sedio26, Andreas Klitgaard14, Charles B. Larson4, Charles B. Larson2, Cristopher A. Boya P., Daniel Torres-Mendoza, David Gonzalez2, Denise Brentan Silva27, Denise Brentan Silva28, Lucas Miranda Marques27, Daniel P. Demarque27, Egle Pociute, Ellis C. O’Neill4, Enora Briand11, Enora Briand4, Eric J. N. Helfrich18, Eve A. Granatosky29, Evgenia Glukhov4, Florian Ryffel18, Hailey Houson, Hosein Mohimani1, Jenan J. Kharbush4, Yi Zeng1, Julia A. Vorholt18, Kenji L. Kurita30, Pep Charusanti1, Kerry L. McPhail31, Kristian Fog Nielsen14, Lisa Vuong, Maryam Elfeki19, Matthew F. Traxler32, Niclas Engene33, Nobuhiro Koyama2, Oliver B. Vining31, Ralph S. Baric24, Ricardo Pianta Rodrigues da Silva27, Samantha J. Mascuch4, Sophie Tomasi11, Stefan Jenkins9, Venkat R. Macherla, Thomas Hoffman, Vinayak Agarwal4, Philip G. Williams34, Jingqui Dai34, Ram P. Neupane34, Joshua R. Gurr34, Andrés M. C. Rodríguez27, Anne Lamsa1, Chen Zhang1, Kathleen Dorrestein2, Brendan M. Duggan2, Jehad Almaliti2, Pierre-Marie Allard35, Prasad Phapale, Louis-Félix Nothias36, Theodore Alexandrov, Marc Litaudon36, Jean-Luc Wolfender35, Jennifer E. Kyle37, Thomas O. Metz37, Tyler Peryea38, Dac-Trung Nguyen38, Danielle VanLeer38, Paul Shinn38, Ajit Jadhav38, Rolf Müller, Katrina M. Waters37, Wenyuan Shi15, Xueting Liu39, Lixin Zhang39, Rob Knight1, Paul R. Jensen4, Bernhard O. Palsson1, Kit Pogliano1, Roger G. Linington30, Marcelino Gutiérrez, Norberto Peporine Lopes27, William H. Gerwick2, William H. Gerwick4, Bradley S. Moore2, Bradley S. Moore4, Pieter C. Dorrestein2, Pieter C. Dorrestein4, Nuno Bandeira2, Nuno Bandeira1 
TL;DR: In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations and data-driven social-networking should facilitate identification of spectra and foster collaborations.
Abstract: The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry (MS) techniques are well-suited to high-throughput characterization of NP, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social Molecular Networking (GNPS; http://gnps.ucsd.edu), an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of 'living data' through continuous reanalysis of deposited data.

2,365 citations

Journal ArticleDOI
TL;DR: Evaluations among the most usual maximum power point tracking techniques, doing meaningful comparisons with respect to the amount of energy extracted from the photovoltaic (PV) panel [tracking factor) in relation to the available power, PV voltage ripple, dynamic response, and use of sensors.
Abstract: This paper presents evaluations among the most usual maximum power point tracking (MPPT) techniques, doing meaningful comparisons with respect to the amount of energy extracted from the photovoltaic (PV) panel [tracking factor (TF)] in relation to the available power, PV voltage ripple, dynamic response, and use of sensors. Using MatLab/Simulink and dSPACE platforms, a digitally controlled boost dc-dc converter was implemented and connected to an Agilent Solar Array E4350B simulator in order to verify the analytical procedures. The main experimental results are presented for conventional MPPT algorithms and improved MPPT algorithms named IC based on proportional-integral (PI) and perturb and observe based on PI. Moreover, the dynamic response and the TF are also evaluated using a user-friendly interface, which is capable of online program power profiles and computes the TF. Finally, a typical daily insulation is used in order to verify the experimental results for the main PV MPPT methods.

1,205 citations

Journal ArticleDOI
A.C.R. da Silva, Jesus Aparecido Ferro1, Fernando C. Reinach2, Chuck S. Farah2, Luiz Roberto Furlan1, Ronaldo Bento Quaggio2, Claudia Barros Monteiro-Vitorello3, M. A. Van Sluys2, Nalvo F. Almeida4, Lucia Maria Carareto Alves1, A. M. do Amaral5, Maria Célia Bertolini1, Luis Eduardo Aranha Camargo3, Giovana Camarotte3, Fabiana de Souza Cannavan, Cardozo Jc1, Felipe S. Chambergo2, L. P. Ciapina1, Regina Maria Barretto Cicarelli1, Luiz Lehmann Coutinho3, Jeny R. Cursino-Santos2, Hamza El-Dorry2, J. B. Faria2, Ari J. S. Ferreira2, Rita de Cássia Café Ferreira2, Maria Inês Tiraboschi Ferro1, Eduardo Fernandes Formighieri, Marília Caixeta Franco, Christian C. Greggio1, Arthur Gruber2, Angela M. Katsuyama2, Luciano Takeshi Kishi1, Rui P. Leite, Eliana Gertrudes de Macedo Lemos1, Manoel Victor Franco Lemos1, E. C. Locali5, Marcos Antonio Machado5, Alda Maria Backx Noronha Madeira2, Nilce Maria Martinez-Rossi2, E. C. Martins1, João Meidanis6, Carlos Frederico Martins Menck2, Cristina Yumi Miyaki2, D. H. Moon, Leandro Marcio Moreira2, M. T. M. Novo1, Vagner K. Okura6, Mariana Cabral de Oliveira2, V. R. Oliveira2, H. A. Pereira1, Antonio Rossi2, Janete Apparecida Desidério Sena1, Cícero Lopes da Silva2, R. F. B. de Souza2, L. A. F. Spinola2, Marco Aurélio Takita5, Rodrigo Esaki Tamura2, E. C. Teixeira1, R. I. D. Tezza1, M. Trindade dos Santos2, Daniela Truffi3, Siu Mui Tsai, Frank F. White7, Frank F. White1, João C. Setubal6, João Paulo Kitajima6 
23 May 2002
TL;DR: The genus Xanthomonas is a diverse and economically important group of bacterial phytopathogens, belonging to the γ-subdivision of the Proteobacteria, and several groups of strain-specific genes are identified and proposed mechanisms that may explain the differing host specificities and pathogenic processes are proposed.
Abstract: The genus Xanthomonas is a diverse and economically important group of bacterial phytopathogens, belonging to the gamma-subdivision of the Proteobacteria. Xanthomonas axonopodis pv. citri (Xac) causes citrus canker, which affects most commercial citrus cultivars, resulting in significant losses worldwide. Symptoms include canker lesions, leading to abscission of fruit and leaves and general tree decline. Xanthomonas campestris pv. campestris (Xcc) causes black rot, which affects crucifers such as Brassica and Arabidopsis. Symptoms include marginal leaf chlorosis and darkening of vascular tissue, accompanied by extensive wilting and necrosis. Xanthomonas campestris pv. campestris is grown commercially to produce the exopolysaccharide xanthan gum, which is used as a viscosifying and stabilizing agent in many industries. Here we report and compare the complete genome sequences of Xac and Xcc. Their distinct disease phenotypes and host ranges belie a high degree of similarity at the genomic level. More than 80% of genes are shared, and gene order is conserved along most of their respective chromosomes. We identified several groups of strain-specific genes, and on the basis of these groups we propose mechanisms that may explain the differing host specificities and pathogenic processes.

1,141 citations

Journal ArticleDOI
24 Apr 2020
TL;DR: The preliminary findings of this study suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 because of its potential safety hazards, especially when taken concurrently with azithromycin and oseltamivir.
Abstract: Importance There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate (CQ) requires a high concentration of the drug. Objective To evaluate the safety and efficacy of 2 CQ dosages in patients with severe COVID-19. Design, Setting, and Participants This parallel, double-masked, randomized, phase IIb clinical trial with 81 adult patients who were hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted from March 23 to April 5, 2020, at a tertiary care facility in Manaus, Brazilian Amazon. Interventions Patients were allocated to receive high-dosage CQ (ie, 600 mg CQ twice daily for 10 days) or low-dosage CQ (ie, 450 mg twice daily on day 1 and once daily for 4 days). Main Outcomes and Measures Primary outcome was reduction in lethality by at least 50% in the high-dosage group compared with the low-dosage group. Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. Outcomes will be presented to day 28. Viral respiratory secretion RNA detection was performed on days 0 and 4. Results Out of a predefined sample size of 440 patients, 81 were enrolled (41 [50.6%] to high-dosage group and 40 [49.4%] to low-dosage group). Enrolled patients had a mean (SD) age of 51.1 (13.9) years, and most (60 [75.3%]) were men. Older age (mean [SD] age, 54.7 [13.7] years vs 47.4 [13.3] years) and more heart disease (5 of 28 [17.9%] vs 0) were seen in the high-dose group. Viral RNA was detected in 31 of 40 (77.5%) and 31 of 41 (75.6%) patients in the low-dosage and high-dosage groups, respectively. Lethality until day 13 was 39.0% in the high-dosage group (16 of 41) and 15.0% in the low-dosage group (6 of 40). The high-dosage group presented more instance of QTc interval greater than 500 milliseconds (7 of 37 [18.9%]) compared with the low-dosage group (4 of 36 [11.1%]). Respiratory secretion at day 4 was negative in only 6 of 27 patients (22.2%). Conclusions and Relevance The preliminary findings of this study suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 because of its potential safety hazards, especially when taken concurrently with azithromycin and oseltamivir. These findings cannot be extrapolated to patients with nonsevere COVID-19. Trial Registration ClinicalTrials.gov Identifier:NCT04323527

852 citations

Journal ArticleDOI
14 Dec 2001-Science
TL;DR: The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids that suggest a recent evolutionary divergence.
Abstract: The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.

797 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202324
2022121
20211,091
20201,252
2019971
2018844