Institution
Federal University of Piauí
Education•Teresina, Brazil•
About: Federal University of Piauí is a education organization based out in Teresina, Brazil. It is known for research contribution in the topics: Population & Medicine. The organization has 8931 authors who have published 10777 publications receiving 82084 citations. The organization is also known as: UFPI & Federal University of Piauí.
Papers published on a yearly basis
Papers
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TL;DR: An overview of the oxidative stress and mitochondrial dysfunction-linked NDDs has been summarized in this review and the effects of reactive species on mitochondria and their metabolic processes eventually cause a rise in ROS/RNS levels.
Abstract: Reactive species play an important role in physiological functions. Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the failure of balance by the body's antioxidant enzyme systems results in destruction of cellular structures, lipids, proteins, and genetic materials such as DNA and RNA. Moreover, the effects of reactive species on mitochondria and their metabolic processes eventually cause a rise in ROS/RNS levels, leading to oxidation of mitochondrial proteins, lipids, and DNA. Oxidative stress has been considered to be linked to the etiology of many diseases, including neurodegenerative diseases (NDDs) such as Alzheimer diseases, Amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, Multiple sclerosis, and Parkinson's diseases. In addition, oxidative stress causing protein misfold may turn to other NDDs include Creutzfeldt-Jakob disease, Bovine Spongiform Encephalopathy, Kuru, Gerstmann-Straussler-Scheinker syndrome, and Fatal Familial Insomnia. An overview of the oxidative stress and mitochondrial dysfunction-linked NDDs has been summarized in this review.
615 citations
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TL;DR: In this paper, total phenolic content and antioxidant activity in the ethanolic extract of leaves, bark and roots of five medicinal plants: Terminalia brasiliensis Camb., Terminalia fagifolia Mart. var.
Abstract: This paper describes total phenolics content and antioxidant activity in the ethanolic extract of leaves, bark and roots of five medicinal plants: Terminalia brasiliensis Camb., Terminalia fagifolia Mart. & Zucc., Copernicia cerifera (Miller) H.E. Moore, Cenostigma macrophyllum Tul. var. acuminata Teles Freire and Qualea grandiflora Mart. The total phenolics content of the plant extracts, determined by the Folin-Ciocalteu method, varied from 250.0 ±8,2 to 763,63 ± 13.03 mg of gallic acid equivalent/g dry EtOH extract. The antioxidant activity of extracts was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay system. Extract of bark from T. brasiliensis, the most active, with an EC50 value of 27.59 ± 0.82 µg/mL, was comparable to rutin (EC50 = 27.80 ± 1.38) and gallic acid (EC50 = 24.27 ± 0.31), used as positive controls. The relationship between total phenolic content and antioxidant activity was positive and significant for T. brasiliensis, C. macrophyllum and C. cerifera.
487 citations
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TL;DR: A novel deep learning framework for the detection and classification of breast cancer in breast cytology images using the concept of transfer learning is proposed and it has been observed that the proposed framework outclass all the other deep learning architectures in terms of accuracy in detection and classified of breast tumor in cytological images.
471 citations
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TL;DR: This review aims to provide updated information about the mechanisms involved in the protective role of zinc against oxidative stress, and provides strong evidence for the role in the protection against oxidativestress in several diseases.
Abstract: Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules, contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human health, because of its antioxidant properties. This review aims to provide updated information about the mechanisms involved in the protective role of zinc against oxidative stress. Zinc acts as a co-factor for important enzymes involved in the proper functioning of the antioxidant defense system. In addition, zinc protects cells against oxidative damage, acts in the stabilization of membranes and inhibits the enzyme nicotinamide adenine dinucleotide phosphate oxidase (NADPH-Oxidase). Zinc also induces the synthesis of metallothioneins, which are proteins effective in reducing hydroxyl radicals and sequestering reactive oxygen species (ROS) produced in stressful situations, such as in type 2 diabetes, obesity and cancer. Literature provides strong evidence for the role of zinc in the protection against oxidative stress in several diseases.
305 citations
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TL;DR: The proposed identification model is based on Mask-RCNN, a deep neural network which incorporates global and local features for pixel-wise segmentation which achieves robustness through critical modifications of the training process and a novel post-processing step which merges bounding boxes from multiple models.
291 citations
Authors
Showing all 9010 results
Name | H-index | Papers | Citations |
---|---|---|---|
António Amorim | 136 | 1477 | 96519 |
Joel J. P. C. Rodrigues | 72 | 1000 | 22175 |
Mariangela Hungria | 67 | 389 | 15219 |
Daniel Sifrim | 63 | 364 | 15124 |
Mahendra Rai | 60 | 410 | 19288 |
Edvani C. Muniz | 51 | 259 | 8940 |
Laécio S. Cavalcante | 45 | 126 | 5624 |
Valtencir Zucolotto | 45 | 212 | 6253 |
Ashish Khanna | 41 | 338 | 6675 |
José Roberto Postali Parra | 40 | 330 | 6814 |
Cláudia Brodskyn | 40 | 129 | 4284 |
Rivelilson Mendes de Freitas | 38 | 230 | 4766 |
José Roberto S. A. Leite | 38 | 204 | 4696 |
Cesar Martins | 38 | 138 | 4673 |
Henrique Douglas Melo Coutinho | 37 | 493 | 6679 |