Institution
Federal University of São Carlos
Education•São Carlos, Brazil•
About: Federal University of São Carlos is a education organization based out in São Carlos, Brazil. It is known for research contribution in the topics: Population & Microstructure. The organization has 16471 authors who have published 34057 publications receiving 456654 citations. The organization is also known as: UFSCar & Federal University of São Carlos.
Topics: Population, Microstructure, Catalysis, Alloy, Crystallization
Papers published on a yearly basis
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TL;DR: It is discovered that ancestral and recent lineages of snakes do not share the same sex chromosome and followed distinct pathways for sex chromosomes evolution.
Abstract: Most of snakes exhibit a ZZ/ZW sex chromosome system, with different stages of degeneration. However, undifferentiated sex chromosomes and unique Y sex-linked markers, suggest that an XY system has also evolved in ancestral lineages. Comparative cytogenetic mappings revealed that several genes share ancestry among X, Y and Z chromosomes, implying that XY and ZW may have undergone transitions during serpent’s evolution. In this study, we performed a comparative cytogenetic analysis to identify homologies of sex chromosomes across ancestral (Henophidia) and more recent (Caenophidia) snakes. Our analysis suggests that, despite ~ 85 myr of independent evolution, henophidians and caenophidians retained conserved synteny over much of their genomes. However, our findings allowed us to discover that ancestral and recent lineages of snakes do not share the same sex chromosome and followed distinct pathways for sex chromosomes evolution.
91 citations
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TL;DR: The data suggest that targeting angiotensin II production or action may represent a valuable therapeutic option to prevent metastatic progression of invasive breast tumors.
Abstract: Breast cancer metastasis is a leading cause of death by malignancy in women worldwide. Efforts are being made to further characterize the rate-limiting steps of cancer metastasis, i.e. extravasation of circulating tumor cells and colonization of secondary organs. In this study, we investigated whether angiotensin II, a major vasoactive peptide both produced locally and released in the bloodstream, may trigger activating signals that contribute to cancer cell extravasation and metastasis. We used an experimental in vivo model of cancer metastasis in which bioluminescent breast tumor cells (D3H2LN) were injected intra-cardiacally into nude mice in order to recapitulate the late and essential steps of metastatic dissemination. Real-time intravital imaging studies revealed that angiotensin II accelerates the formation of metastatic foci at secondary sites. Pre-treatment of cancer cells with the peptide increases the number of mice with metastases, as well as the number and size of metastases per mouse. In vitro, angiotensin II contributes to each sequential step of cancer metastasis by promoting cancer cell adhesion to endothelial cells, trans-endothelial migration and tumor cell migration across extracellular matrix. At the molecular level, a total of 102 genes differentially expressed following angiotensin II pre-treatment were identified by comparative DNA microarray. Angiotensin II regulates two groups of connected genes related to its precursor angiotensinogen. Among those, up-regulated MMP2/MMP9 and ICAM1 stand at the crossroad of a network of genes involved in cell adhesion, migration and invasion. Our data suggest that targeting angiotensin II production or action may represent a valuable therapeutic option to prevent metastatic progression of invasive breast tumors.
91 citations
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TL;DR: The saponins isolated showed strong activity against C. parapsilosis, and the hydroalcoholic extract was bioactivity-directed against a clinical isolate of C. albicans, and showing strong activity.
Abstract: Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis, C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extract was bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extract and one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separation of this fraction afforded two pure triterpene acetylated saponins: 3-O-(4-acetyl-β-D-xylopyranosyl)-(1→3)-α-Lrhamnopyranosyl-(1→2)-α-L-arabinopyranosyl-hederagenin (1) and 3-O-(3,4-di-acetyl-β-D-xylopyranosyl)-(1→3)α-L-rhamnopyranosyl-(1→2)-α- L-arabynopyranosyl-hederagenin (2). The structures of the compounds were based on spectral data ( 1 Ha nd 13 C NMR, HSQC, HMBC and MS), and on with literature. The saponins isolated showed
91 citations
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TL;DR: In this article, an efficient and ligand-free cross-coupling reaction of organic diselenides with aryl boronic acids using a catalytic amount of CuO nanoparticles in DMSO at 100°C under air atmosphere was presented.
91 citations
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TL;DR: Results showed that acute exposure to Al causes an ionic unbalance, probably related to the effects of Al on Na(+)/K(+)-ATPase activity, on the distribution and number of chloride cells in the gills as well as the effects associated with the stress response caused by the presence of the metal.
91 citations
Authors
Showing all 16693 results
Name | H-index | Papers | Citations |
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Akihisa Inoue | 126 | 2652 | 93980 |
Michael R. Hamblin | 117 | 899 | 59533 |
Daniel P. Costa | 89 | 531 | 26309 |
Elson Longo | 86 | 1454 | 40494 |
Ross Arena | 81 | 671 | 39949 |
Tom M. Mitchell | 76 | 315 | 41956 |
José Arana Varela | 76 | 748 | 23005 |
Luiz H. C. Mattoso | 66 | 455 | 17432 |
Steve F. Perry | 66 | 294 | 13842 |
Edson R. Leite | 63 | 535 | 15303 |
Juan Andrés | 60 | 493 | 13499 |
Edward R. T. Tiekink | 60 | 1967 | 21052 |
Alex A. Freitas | 60 | 345 | 14789 |
Mary F. Mahon | 59 | 539 | 14258 |
Osvaldo N. Oliveira | 59 | 614 | 16369 |