Federal University of São Carlos

About: Federal University of São Carlos is a education organization based out in São Carlos, Brazil. It is known for research contribution in the topics: Population & Microstructure. The organization has 16471 authors who have published 34057 publications receiving 456654 citations. The organization is also known as: UFSCar & Federal University of São Carlos.

Reading, equivalence, and recombination of units: a replication with students with different learning histories.

Abstract: First graders, preschoolers, special education students, and adults received a reading program in which they learned to match printed to dictated words and to construct (copy) printed words. The students not only learned to match the training words but also learned to read them. In addition, most of the students learned to read new words that involved recombinations of the syllables of the training words. The results replicate and extend the generality of a prior analysis of a reading program based on stimulus equivalence and recombination of units.

Digital physical therapy in the COVID-19 pandemic.

Abstract: b t h o t t a g b t s s l On March 11th/2020, the World Health Organization (WHO) declared Coronavirus Disease 2019 (COVID-19), a disease caused by the new coronavirus (severe acute respiratory syndrome coronavirus 2-SARS-COV-2), a pandemic.1 In this global crisis, physical therapy all over the world, is being challenged to maintain its professional clinical activities in primary and secondary care in private clinics and public health systems.2,3 Part of the challenge is to continue to provide necessary clinical care in a safe manner, for physical therapists, patients, and the community, by following the general recommendations of the WHO.1 Social distancing and the interruption of physical therapy activities can have a tremendous negative impact on the health of thousands of patients. Digital physical therapy offers the possibility to continue providing some physical therapy services to patients, but regulations and implementation barriers are extremely heterogeneous around the world.

A novel αvβ3-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis

Abstract: The integrin αvβ3 is involved in multiple aspects of malignant cancer, including tumor angiogenesis and metastasis, which makes the receptor a key target for the development of anti-cancer therapies. We report here on the production, the characterization and the in vivo anti-angiogenic and anti-metastatic properties of a novel αvβ3-binding disintegrin, DisBa-01, isolated from a cDNA library made with RNAs from the venom gland of Bothrops alternatus. The 11,637 Da-recombinant monomeric form of DisBa-01 displayed an RGD motif and interacted with purified αvβ3 integrin in surface plasmon resonance studies, in a dose-dependent and cation sensitive manner. A three-dimensional molecular model of DisBa-01 in complex with αvβ3 predicted a large surface of contacts with the β3 subunit. DisBa-01 inhibited the adhesion of αvβ3-expressing human microvascular endothelial cell line-1 (HMEC-1) and murine melanoma cell line B16F10 to vitronectin (IC50 = 555 nM and 225 nM, respectively), and transiently inhibited their proliferation without direct cell toxicity, but did not affect the binding nor the proliferation of a human breast cancer-derived cell line (MDA-MB-231) not expressing αvβ3. In vivo, DisBa-01 dose-dependently decreased bFGF-induced angiogenesis in a matrigel plug assay in athymic nude mice (IC50 = 83 nM). When injected intravenously to C57BL/6 mice together with B16F10 melanoma cells, DisBa-01 time- and dose-dependently inhibited lung metastasis monitored by bioluminescent imaging. We conclude that DisBa-01 is a potent new inhibitor of αvβ3-dependent adherence mechanisms involved in neo-vascularization and tumor metastasis processes.

Characterization of plasma-nitrided iron by XRD, SEM and XPS

Abstract: The plasma nitriding technique has been used to improve the tribological and mechanical properties of materials, especially iron-based alloys. In this work, the pulsed glow discharge (PGD) technique was used for nitriding pure iron. Three samples were nitrided in a gas mixture of 80 vol.% H 2 and 20 vol.% N 2 under a pressure of 400 Pa, discharge frequency of 9 kHz, and temperature of 580 °C. Samples A, B and C were nitrided for 30 min, 60 min and 90 min, respectively. The nitrided iron samples were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectrometry (EDS), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). SEM micrographs showed differences in the surface morphologies among the samples. XRD identified the γ′-Fe 4 N and e-Fe 2–3 N phases in all samples. The Rietveld analysis was performed in order to investigate the concentration variations of the phases as a function of nitriding time. XPS was employed to obtain chemical-state and semi-quantitative information, and revealed a thin film of Fe 2 O 3 covering a Fe 3 O 4 layer formed on top of the Fe 2–3 N and Fe 4 N layers.