Federal University of São Paulo

About: Federal University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Medicine. The organization has 27971 authors who have published 49365 publications receiving 935536 citations. The organization is also known as: Universidade Federal de São Paulo & Universidade Federal de Sao Paulo.

Dark matter complementarity and the Z ′ portal

Abstract: Z 0 gauge bosons arise in many particle physics models as mediators between the dark and visible sectors. We exploit dark matter complementarity and derive stringent and robust collider, direct and indirect constraints, as well as limits from the muon magnetic moment. We rule out almost the entire region of the parameter space that yields the right dark matter thermal relic abundance, using a generic parametrization of the Z 0 -fermion couplings normalized to the Standard Model Z-fermion couplings for dark matter masses in the 8 GeV-5 TeV range. We conclude that mediators lighter than 2:1 TeV are excluded regardless of the DM mass, and that depending on theZ 0 fermion coupling strength much heavier masses are needed to reproduce the DM thermal relic abundance while avoiding existing limits.

The central role of the gut microbiota in chronic inflammatory diseases.

Abstract: The commensal microbiota is in constant interaction with the immune system, teaching immune cells to respond to antigens. Studies in mice have demonstrated that manipulation of the intestinal microbiota alters host immune cell homeostasis. Additionally, metagenomic-sequencing analysis has revealed alterations in intestinal microbiota in patients suffering from inflammatory bowel disease, asthma, and obesity. Perturbations in the microbiota composition result in a deficient immune response and impaired tolerance to commensal microorganisms. Due to altered microbiota composition which is associated to some inflammatory diseases, several strategies, such as the administration of probiotics, diet, and antibiotic usage, have been utilized to prevent or ameliorate chronic inflammatory diseases. The purpose of this review is to present and discuss recent evidence showing that the gut microbiota controls immune system function and onset, development, and resolution of some common inflammatory diseases.

Infectivity of Trypanosoma cruzi strains is associated with differential expression of surface glycoproteins with differential Ca2+ signalling activity

Abstract: Mammalian cell invasion assays, using metacyclic trypomastigotes of Trypanosoma cruzi G and CL strains, showed that the CL strain enters target cells in several-fold higher numbers as compared with the G strain. Analysis of expression of surface glycoproteins in metacyclic forms of the two strains by iodination, immunoprecipitation and FACS, revealed that gp90, undetectable in the CL strain, is one of the major surface molecules in the G strain, that expression of gp82 is comparable in both strains and that gp35/50 is expressed at lower levels in the CL strain. Purified gp90 and gp35/50 bound more efficiently than gp82 to cultured HeLa cells. However, the intensity of the Ca2+ response triggered in HeLa cells by gp82 was significantly higher than that induced by gp35/50 or gp90. Most of the Ca2+ signalling activity of the metacyclic extract towards HeLa cells was due to gp82 and was inhibitable by gp82-specific monoclonal antibody 3F6. Ca2+ mobilization was also triggered in metacyclic trypomastigotes by host-cell components; it was mainly gp82-mediated and more intense in the CL than in the G strain. We propose that expression of gp90 and gp35/50 at high levels impairs binding of metacyclic forms to host cells through productive gp82-mediated interaction, which leads to the target-cell and parasite Ca2+ mobilization required for invasion. Analysis of metacyclic forms of eight additional T. cruzi strains corroborated the inverse correlation between infectivity and expression of gp90 and gp35/50.

TFOS DEWS II Introduction

Abstract: J. Daniel Nelson, MD a, b, , Jennifer P. Craig, MCOptom, PhD , Esen K. Akpek MD , Dimitri T. Azar, MD , Carlos Belmonte, MD, PhD f, , Anthony J. Bron, FRCOphth, FMedSci h, , Janine A. Clayton, MD , Murat Dogru, MD, PhD k, , Harminder S. Dua, MD, PhD , Gary N. Foulks, MD , Jos e A.P. Gomes, MD, PhD , Katherine M. Hammitt, MA , Juha Holopainen, MD, PhD , Lyndon Jones, FCOptom, PhD , Choun-Ki Joo, MD, PhD , Zuguo Liu, MD, PhD , Jason J. Nichols, OD, PhD , Kelly K. Nichols, OD, PhD , Gary D. Novack, PhD v, , Virender Sangwan, MBBS, MS , Fiona Stapleton, MCOptom, PhD , Alan Tomlinson, FCOptom, DSc , Kazuo Tsubota, MD , Mark D.P. Willcox, PhD, DSc , James S. Wolffsohn, FCOptom PhD , David A. Sullivan, PhD ac

Seasonal variation, chemical composition and antioxidant activity of Brazilian propolis samples.

Abstract: Total phenolic contents, antioxidant activity and chemical composition of propolis samples from three localities of Minas Gerais state (southeast Brazil) were determined. Total phenolic contents were determined by the Folin–Ciocalteau method, antioxidant activity was evaluated by DPPH, using BHT as reference, and chemical composition was analyzed by GC/MS. Propolis from Itapecerica and Paula Cândido municipalities were found to have high phenolic contents and pronounced antioxidant activity. From these extracts, 40 substances were identified, among them were simple phenylpropanoids, prenylated phenylpropanoids, sesqui- and diterpenoids. Quantitatively, the main constituent of both samples was allyl-3-prenylcinnamic acid. A sample from Virginopolis municipality had no detectable phenolic substances and contained mainly triterpenoids, the main constituents being α- and β-amyrins. Methanolic extracts from Itapecerica and Paula Cândido exhibited pronounced scavenging activity towards DPPH, indistinguishable from BHT activity. However, extracts from Virginopolis sample exhibited no antioxidant activity. Total phenolic substances, GC/MS analyses and antioxidant activity of samples from Itapecerica collected monthly over a period of 1 year revealed considerable variation. No correlation was observed between antioxidant activity and either total phenolic contents or contents of artepillin C and other phenolic substances, as assayed by CG/MS analysis.