Institution
Federal University of São Paulo
Education•São Paulo, Brazil•
About: Federal University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Medicine. The organization has 27971 authors who have published 49365 publications receiving 935536 citations. The organization is also known as: Universidade Federal de São Paulo & Universidade Federal de Sao Paulo.
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Federal University of São Paulo1, Federal University of Rio de Janeiro2, Federal University of Bahia3, University of São Paulo4, Universidade Federal do Espírito Santo5, Federal University of Rio Grande do Norte6, Oswaldo Cruz Foundation7, Federal University of Pará8, Federal University of Paraná9, Universidade Federal de Minas Gerais10
TL;DR: “.” ˛˚ ˛ ˜ˇ 2 ˆ````龍左 𝚘 , 7˚, 7˘ ݘ ンジャック, ݚ വ’ “’Benedictine’s Law”, 2 January 2017.
Abstract: ˝ ˛˚ ˛ ˜ˇ 2 ˆ ˜˚ / $ & B@H/#$˝ !" #˛ $ 2 $˚ ˘ , 7˘ 1 0 =˙1B˛ H " E " $ % & ’$ ˛ 2 D 0 @ ˚ "˜7 ?’ H ˚ 2 &’ # ˝˛ ˚ ( " 2 ˆ $ ˘˚ B˛ H ˇ ˝˛) * ˛˛ 2 $˚ ˘ , 7˘ 1 0 =˙1B˛ H " E 1" $ ˘ " $˚ ˝+ ˛,- ˘ # ˚ 5 A 0 =˙1B˛ H " E ˚." / 2 H & 2 B#$ " $ " $ ˚ 0 ˚˛˛1 2 $$&( B˛ H " E A # $ 1" $ 2/ 3 2 @ ˜ 2 H & B˛ H /ˆ˝ # 1" $ 2/ " 2 # / # $ ˝ 2 $42 (˛ 2 ?ˆ 85˛ & ˚ 2 # / # ˇ ˜ ˛ ˇ 5 6( 2 $˚ ˘ , 7˘ 1 0 =˙1B˛ H " E A " $ ˜ ˝ ˛˜76 ( 2 ˘ H 2 # / # # $ # $ , , ˇ ˛˜ˇ 2 H , ˆˇ $ ˛ " E ,/˝˛( ’ 2 $˚ ˘ , 7˘ 1 0 =˙ 2 B˛ H " E # ˚ 5 , / 2 #)# $˚ ˘ @ #1, 2 &’ # 3.)+ 8 2 ?ˆ B˛5 $ / 2 B˛ / " E 3 + ˚ 2 "˜7 ?’ H ˚ 2 &’ # 3+ ˛’˛˘ B˛ H " ( @9: 2 2 # ˛ 2 B˛ H ˇ .) + 2 $˜˝ B˛ 0 ˙$B 2 # # $ .; 2 "˜7 ?’ H ˚ 2 &’ # A B˛ / " E ’"? ˛ 2 # ˛ 2 B˛ H ˇ 1" $ ( ˝+3@@ 2 "˜7 ?’ H ˚ 2 #)# &’ # (A’# *ˇ˝ 2 ?ˆ & ˆ " ˆˇ $ # - #˙"EA $˚ ˘ , 7˘ 1 0 =˙ 2 B˛ H " E * ˚/6˚ 2 ?ˆ B˛5 E 2 ’˘ B˛ H $ 5*9 6 2 # ˛ 2 B˛ H ˇ B/3 8 (ˇ6" ˛ 2 ˛ ˜ ?ˆ ˝ H & B˛ # $ ’ 2 ?ˆ # 0 $ ˇ $ ,˚ # / # 2 "# " $ ) <˜ / 2 ˆ $ ˘˚ B˛ H $ 5A ˘ ˜. #$ ˚/’˛ 2 # # & ˝ˆ " E 1" $ (? 2 # ˛ 2 B˛ H ˇ 1" $ C.(˝ ˛ 2 H & ˆ $ ˘˚ B˛ H & ( C , 2 2 )/ 2 # / # # $ 1" $ &$< ˛ 2 "˜7 #1, # / # # $ A H & B˛ # $ 4 ˛ D & ˚ ˇ ˘ H , ˚ H - & J KL $ $
156 citations
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French Institute of Health and Medical Research1, Royal Adelaide Hospital2, University of Hamburg3, Federal University of São Paulo4, University of Nantes5, University of Zurich6, Northwestern University7, University of California, San Diego8, University of Milan9, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico10, University of Padua11, The Chinese University of Hong Kong12
TL;DR: It is proposed that high‐resolution manometry (HRM) is now the gold standard to assess esophageal motility and a consensus definition of TLESRs using HRM is proposed.
Abstract: BACKGROUND: Criteria for transient lower esophageal sphincter relaxations (TLESRs) are well-defined for Dentsleeve manometry. As high-resolution manometry (HRM) is now the gold standard to assess esophageal motility, our aim was to propose a consensus definition of TLESRs using HRM.
METHODS: Postprandial esophageal HRM combined with impedance was performed in 10 patients with gastroesophageal reflux disease. Transient lower esophageal sphincter relaxations identification was performed by 17 experts using a Delphi process. Four investigators then characterized TLESR candidates that achieved 100% agreement (TLESR events) and those that achieved less than 25% agreement (non-events) after the third round. Logistic regression and decision tree analysis were used to define optimal diagnostic criteria.
KEY RESULTS: All diagnostic criteria were more frequently encountered in the 57 TLESR events than in the 52 non-events. Crural diaphragm (CD) inhibition and LES relaxation duration >10 seconds had the highest predictive value to identify TLESR. Based on decision tree analysis, reflux on impedance, esophageal shortening, common cavity, upper esophageal sphincter relaxation without swallow and secondary peristalsis were alternate diagnostic criteria.
CONCLUSION & INFERENCES: Using HRM, TLESR might be defined as LES relaxation occurring in absence of swallowing, lasting more than 10 seconds and associated with CD inhibition.
156 citations
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TL;DR: In intake of fiber below the minimum recommendation is a risk factor for chronic constipation in children.
Abstract: Background:Scarce information exists regarding dietary fiber intake in children with chronic constipation. The objective of this case-control study was to evaluate the intake of fiber as a risk factor for chronic constipation.Methods:Fifty-two children with a mean age of 6.8 ± 3.2 years who
156 citations
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TL;DR: A risk prediction model, the Pre-eclampsia Integrated Estimate of RiSk (miniPIERS) is used to help inform the clinical assessment and triage of women with hypertensive disorders of pregnancy in low-resourced settings.
Abstract: Please cite as follows: Payne, B. A. 2014. A risk prediction model for the assessment and triage of women with hypertensive disorders of pregnancy in low-resourced settings: the miniPIERS (pre-eclampsia integrated estimate of risk) multi-country prospective cohort study. PLoS Medicine, 11(1):e1001589, doi:10.1371/journal.pmed.1001589.
156 citations
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TL;DR: The phenomenon of immunosenescence, which entails changes that occur in both innate and adaptive immunity with aging, is discussed, and inflamm-aging, a low-grade inflammatory state triggered by continuous antigenic stimulation, which may ultimately increase all-cause mortality is discussed.
Abstract: Elderly individuals are the most susceptible to an aggressive form of coronavirus disease (COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed among the elderly could explain, at least in part, the age gradient in lethality of COVID-19. In this review, we will discuss the phenomenon of immunosenescence, which entails changes that occur in both innate and adaptive immunity with aging. Furthermore, we will discuss inflamm-aging, a low-grade inflammatory state triggered by continuous antigenic stimulation, which may ultimately increase all-cause mortality. In general, the elderly are less capable of responding to neo-antigens, because of lower naive T cell frequency. Furthermore, they have an expansion of memory T cells with a shrinkage of the T cell diversity repertoire. When infected by SARS-CoV-2, young people present with a milder disease as they frequently clear the virus through an efficient adaptive immune response. Indeed, antibody-secreting cells and follicular helper T cells are thought to be effectively activated in young patients that present a favorable prognosis. In contrast, the elderly are more prone to an uncontrolled activation of innate immune response that leads to cytokine release syndrome and tissue damage. The failure to trigger an effective adaptive immune response in combination with a higher pro-inflammatory tonus may explain why the elderly do not appropriately control viral replication and the potential clinical consequences triggered by a cytokine storm, endothelial injury, and disseminated organ injury. Enhancing the efficacy of the adaptive immune response may be an important issue both for infection resolution as well as for the appropriate generation of immunity upon vaccination, while inhibiting inflamm-aging will likely emerge as a potential complementary therapeutic approach in the management of patients with severe COVID-19.
156 citations
Authors
Showing all 28240 results
Name | H-index | Papers | Citations |
---|---|---|---|
Majid Ezzati | 133 | 443 | 137171 |
Christian Guilleminault | 133 | 897 | 68844 |
Jean Rivier | 133 | 769 | 73919 |
Myron M. Levine | 123 | 789 | 60865 |
Werner Seeger | 114 | 1113 | 57464 |
Katherine L. Tucker | 106 | 683 | 39404 |
Michael Bader | 103 | 735 | 37525 |
Paulo A. Lotufo | 89 | 622 | 100527 |
Fernando Q. Cunha | 88 | 682 | 31501 |
Paul R. Sanberg | 87 | 635 | 29745 |
Harold A. Chapman | 87 | 191 | 26617 |
Ricardo T. Gazzinelli | 86 | 340 | 28233 |
Carlito B. Lebrilla | 86 | 495 | 25415 |
Roger S. McIntyre | 85 | 807 | 32040 |
Sergio Tufik | 85 | 1424 | 35174 |