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Institution

Federal University of São Paulo

EducationSão Paulo, Brazil
About: Federal University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Transplantation. The organization has 27971 authors who have published 49365 publications receiving 935536 citations. The organization is also known as: Universidade Federal de São Paulo & Universidade Federal de Sao Paulo.


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Journal ArticleDOI
TL;DR: Treatment with third-generation cephalosporins and being at one of the hospitals were associated with infection due to MDR Gram-negative isolates, and these findings may have important clinical implications in the decision of giving prophylaxis and selecting the empiric antibiotic regimen.
Abstract: The incidence of Gram-negative bacteremia has increased in hematopoietic stem cell transplant (HSCT) recipients We prospectively collected data from 13 Brazilian HSCT centers to characterize the epidemiology of bacteremia occurring early post transplant, and to identify factors associated with infection due to multi-drug-resistant (MDR) Gram-negative isolates MDR was defined as an isolate with resistance to at least two of the following: third- or fourth-generation cephalosporins, carbapenems or piperacillin-tazobactam Among 411 HSCT, fever occurred in 333, and 91 developed bacteremia (118 isolates): 47% owing to Gram-positive, 37% owing to Gram-negative, and 16% caused by Gram-positive and Gram-negative bacteria Pseudomonas aeruginosa (22%), Klebsiella pneumoniae (19%) and Escherichia coli (17%) accounted for the majority of Gram-negative isolates, and 37% were MDR These isolates were recovered from 20 patients, representing 5% of all 411 HSCT and 22% of the episodes with bacteremia By multivariate analysis, treatment with third-generation cephalosporins (odds ratio (OR) 1065, 95% confidence interval (CI) 375-3027) and being at one of the hospitals (OR 947, 95% CI 260-3440) were associated with infection due to MDR Gram-negative isolates These findings may have important clinical implications in the decision of giving prophylaxis and selecting the empiric antibiotic regimen

153 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigate the perfil de utilizacao de medicamentos by idosos residentes in areas of diferentes nivel socioeconomico of a centro urbano do Nordeste do Brazil.
Abstract: OBJETIVO: Descrever o perfil de utilizacao de medicamentos por idosos residentes em areas de diferentes niveis socioeconomicos de um centro urbano do Nordeste do Brasil. METODOS: Inquerito domiciliar entre idosos (60 anos ou mais) da cidade de Fortaleza, Ceara, selecionados por amostragem sistematica em multiplos estagios e estratificada por nivel socioeconomico (melhor = area central; intermediario = area intermediaria; pior = area periferica). Estatistica descritiva foi apresentada pelas percentagens dos respectivos totais para variaveis categoricas e medias (± desvio-padrao) para variavel continua. Realizou-se analise multivariada para identificacao de fatores associados a uso de medicamentos prescritos; nao-prescritos e inadequados. RESULTADOS: A maioria dos idosos (80,3% na area central) usava pelo menos um medicamento prescrito. Mais de um terco (37,4%) na area periferica usava pelo menos um nao-prescrito, e quase 20% pelo menos um inadequado. O uso de medicamentos prescritos foi associado a idade avancada (razao de chances - RR=1,7; IC 95%: 1,1-2,8); sexo masculino (RR=0,5; IC 95%: 0,3-0,7); visitas a servicos de saude (RR=2,5; IC 95%: 1,9-3,1); doencas cronicas (RR=4,0; IC 95%: 2,5-6,2); e nivel socioeconomico (RR=2,0; IC 95%: 1,5-2,6). O uso de medicamentos nao prescritos foi associado a comprometimento funcional (RR=1,5; IC 95%: 1,1-2,2) e nivel socioeconomico (RR=0,6; IC 95%: 0,5-0,8). O uso de medicamentos inadequados foi associado principalmente a sexo masculino (RR=0,4; IC 95%: 0,2-0,8); doencas cronicas (RR=2,0; IC 95%: 1,2-3,3), e nivel socioeconomico (RR=0,7; IC 95%: 0,5-0,9). CONCLUSOES: As proporcoes de idosos usando medicamentos prescritos, nao-prescritos e inadequados foram significativas, havendo desigualdades particularmente entre aqueles de diferentes niveis socioeconomicos. Os resultados apontam para a necessidade de programas para otimizar o acesso e racionalizar o uso de medicamentos entre idosos no Brasil.

153 citations

Journal ArticleDOI
TL;DR: FSGS was the most frequent primary glomerular disease, followed closely by MN and IgAN, in accordance with recent studies all over the world that revealed its frequency is increasing.
Abstract: Background. Studies about the prevalence of renal and particularly glomerular diseases in Brazil are still scarce. Methods. We evaluated retrospectively the reports of 9,617 renal biopsies, analyzed by the same pathologist, from January 1993 to December 2007. Results. The 9,617 renal biopsies performed in subjects of all ages in native kidneys. 4,619 were primary glomerulopathies (GN), the most frequent was focal segmental glomerulosclerosis (FSGS, 24.6%), followed by membranous nephropathy (MN, 20.7%), IgA nephropathy (IgAN, 20.1%), minimal change disease (MCD, 15.5%), mesangioproliferative non IgAN (nonIgAN, 5.2%), diffuse proliferative GN (DPGN, 4.7%) and membranoproliferative GN (MPGN, 4.2%). Lupus nephritis was responsible for most cases which etiology was determined, i.e., 950 out of 2,046 cases (45.5%), followed by post infectious GN (18.9%), diabetic nephropathy (8.5%), benign and malignant nephroangiosclerosis (7.3%), haemolytic–uraemic syndrome and thrombotic thrombocytopenic purpura (HUS/TTP), amyloidosis (4.8%) and vasculitis (4.7%). There was a predominance of secondary GN in the North, mostly due to lupus nephritis (LN); FSGS was very common in Northeast (27.7%), Central (26.9%) and Southeast regions (24.1%); IgAN was most frequent in South (22.8%) and MN in North (29.6%); the total prevalence of MPGN was low, and its regional distribution has not changed along the years. Conclusion. FSGS was the most frequent primary glomerular disease, followed closely by MN and IgAN. The predominance of FSGS is in accordance with recent studies all over the world that revealed its frequency is increasing. Lupus nephritis predominated among secondary GN in most regions, a finding observed in other studies.

153 citations

Journal ArticleDOI
TL;DR: To understand better the natural history of ocular toxoplasmosis by reexamining a well-characterized population in Southern Brazil, small, non-specific hyperpigmented retinal lesions may represent sites of T. gondii infection in seropositive individuals.

153 citations

Journal ArticleDOI
TL;DR: The pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs.
Abstract: The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.

153 citations


Authors

Showing all 28240 results

NameH-indexPapersCitations
Majid Ezzati133443137171
Christian Guilleminault13389768844
Jean Rivier13376973919
Myron M. Levine12378960865
Werner Seeger114111357464
Katherine L. Tucker10668339404
Michael Bader10373537525
Paulo A. Lotufo89622100527
Fernando Q. Cunha8868231501
Paul R. Sanberg8763529745
Harold A. Chapman8719126617
Ricardo T. Gazzinelli8634028233
Carlito B. Lebrilla8649525415
Roger S. McIntyre8580732040
Sergio Tufik85142435174
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202372
2022409
20213,981
20203,843
20193,234
20182,898