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Institution

Federal University of São Paulo

EducationSão Paulo, Brazil
About: Federal University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Transplantation. The organization has 27971 authors who have published 49365 publications receiving 935536 citations. The organization is also known as: Universidade Federal de São Paulo & Universidade Federal de Sao Paulo.


Papers
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Journal ArticleDOI
TL;DR: The structural characteristics of the heparan sulfate proteoglycans related to protein interactions leading to cell signaling and endocytic uptake pathways are focused on.
Abstract: Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions leading to cell signaling The heparan sulfate chains due to their vast structural diversity are able to bind and interact with a wide variety of proteins, such as growth factors, chemokines, morphogens, extracellular matrix components, enzymes, among others There is a specificity directing the interactions of heparan sulfates and target proteins, regarding both the fine structure of the polysaccharide chain as well precise protein motifs Heparan sulfates play a role in cellular signaling either as receptor or co-receptor for different ligands, and the activation of downstream pathways is related to phosphorylation of different cytosolic proteins either directly or involving cytoskeleton interactions leading to gene regulation The role of the heparan sulfate proteoglycans in cellular signaling and endocytic uptake pathways is also discussed

216 citations

Journal ArticleDOI
TL;DR: The most well known adjuvants used in experimental and clinical settings are described based on their main mechanisms of action and the requirements for licensing new vaccine formulations are highlighted.
Abstract: Vaccination is one of the most efficient strategies for the prevention of infectious diseases. Although safer, subunit vaccines are poorly immunogenic and for this reason the use of adjuvants is strongly recommended. Since their discovery in the beginning of the 20th century, adjuvants have been used to improve immune responses that ultimately lead to protection against disease. The choice of the adjuvant is of utmost importance as it can stimulate protective immunity. Their mechanisms of action have now been revealed. Our increasing understanding of the immune system, and of correlates of protection, is helping in the development of new vaccine formulations for global infections. Nevertheless, few adjuvants are licensed for human vaccines and several formulations are now being evaluated in clinical trials. In this review, we briefly describe the most well known adjuvants used in experimental and clinical settings based on their main mechanisms of action and also highlight the requirements for licensing new vaccine formulations.

215 citations

Journal ArticleDOI
TL;DR: The receiver operating characteristic (ROC) curve was used to identify cutoff points that maximized sensitivity and specificity in discriminating mild keratoconus from normal corneas and showed a poor overall predictive accuracy of CH and CRF.

214 citations

Journal ArticleDOI
TL;DR: Prior reviews of mortality in epilepsy are updated to reevaluate and quantify the risks, potential risk factors, and causes of these deaths and to identify those studies likely to accurately quantify these risks in representative populations.
Abstract: Since previous reviews of epidemiologic studies of premature mortality among people with epilepsy were completed several years ago, a large body of new evidence about this subject has been published. We aim to update prior reviews of mortality in epilepsy and to reevaluate and quantify the risks, potential risk factors, and causes of these deaths. We systematically searched the Medline and Embase databases to identify published reports describing mortality risks in cohorts and populations of people with epilepsy. We reviewed relevant reports and applied criteria to identify those studies likely to accurately quantify these risks in representative populations. From these we extracted and summarized the reported data. All population-based studies reported an increased risk of premature mortality among people with epilepsy compared to general populations. Standard mortality ratios are especially high among people with epilepsy aged <50 years, among those whose epilepsy is categorized as structural/metabolic, those whose seizures do not fully remit under treatment, and those with convulsive seizures. Among deaths directly attributable to epilepsy or seizures, important immediate causes include sudden unexpected death in epilepsy (SUDEP), status epilepticus, unintentional injuries, and suicide. Epilepsy-associated premature mortality imposes a significant public health burden, and many of the specific causes of death are potentially preventable. These require increased attention from healthcare providers, researchers, and public health professionals.

214 citations

Journal ArticleDOI
TL;DR: It is suggested that cats represent a major host and the main source of cat and human S. brasiliensis infections in Brazil and the epidemic has at least two distinct sources.
Abstract: Sporothrix schenckii, previously assumed to be the sole agent of human and animal sporotrichosis, is in fact a species complex. Recently recognized taxa include S. brasiliensis, S. globosa, S. mexicana, and S. luriei, in addition to S. schenckii sensu stricto. Over the last decades, large epidemics of sporotrichosis occurred in Brazil due to zoonotic transmission, and cats were pointed out as key susceptible hosts. In order to understand the eco-epidemiology of feline sporotrichosis and its role in human sporotrichosis a survey was conducted among symptomatic cats. Prevalence and phylogenetic relationships among feline Sporothrix species were investigated by reconstructing their phylogenetic origin using the calmodulin (CAL) and the translation elongation factor-1 alpha (EF1α) loci in strains originated from Rio de Janeiro (RJ, n = 15), Rio Grande do Sul (RS, n = 10), Parana (PR, n = 4), Sao Paulo (SP, n = 3) and Minas Gerais (MG, n = 1). Our results showed that S. brasiliensis is highly prevalent among cats (96.9%) with sporotrichosis, while S. schenckii was identified only once. The genotype of Sporothrix from cats was found identical to S. brasiliensis from human sources confirming that the disease is transmitted by cats. Sporothrix brasiliensis presented low genetic diversity compared to its sister taxon S. schenckii. No evidence of recombination in S. brasiliensis was found by split decomposition or PHI-test analysis, suggesting that S. brasiliensis is a clonal species. Strains recovered in states SP, MG and PR share the genotype of the RJ outbreak, different from the RS clone. The occurrence of separate genotypes among strains indicated that the Brazilian S. brasiliensis epidemic has at least two distinct sources. We suggest that cats represent a major host and the main source of cat and human S. brasiliensis infections in Brazil.

213 citations


Authors

Showing all 28240 results

NameH-indexPapersCitations
Majid Ezzati133443137171
Christian Guilleminault13389768844
Jean Rivier13376973919
Myron M. Levine12378960865
Werner Seeger114111357464
Katherine L. Tucker10668339404
Michael Bader10373537525
Paulo A. Lotufo89622100527
Fernando Q. Cunha8868231501
Paul R. Sanberg8763529745
Harold A. Chapman8719126617
Ricardo T. Gazzinelli8634028233
Carlito B. Lebrilla8649525415
Roger S. McIntyre8580732040
Sergio Tufik85142435174
Network Information
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202372
2022409
20213,981
20203,843
20193,234
20182,898