Institution
Federal University of São Paulo
Education•São Paulo, Brazil•
About: Federal University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Transplantation. The organization has 27971 authors who have published 49365 publications receiving 935536 citations. The organization is also known as: Universidade Federal de São Paulo & Universidade Federal de Sao Paulo.
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TL;DR: When analysed as the underlying cause of death, paracoccidioidomycosis represented the most important cause of deaths among systemic mycoses (approximately 51.2%) and cryptococcosis appeared at the top of the list, followed by candidiasis (30.2%), histoplasmosis (10.1%) and others.
Abstract: In Brazil, epidemiological research on mortality is carried out by the Mortality Information System (MIS), created in 1976 with the implementation throughout the national territory of a standardised death certificate (DC). Even though data from the MIS are abundant and trustworthy for mortality studies, some states in Brazil still have uncertain coverage and information quality, with high rates of under-registration of deaths. Underregistration has primarily been attributed to the custom of performing burials without a formal DC, which generally occurs in poor and rural areas. Studies from the Ministry of Health showed that death information in the MIS covered 94.6% of deaths in the South, 90.9% in the Southeast, 87.3% in the Central West and 74.6% in the North and Northeast of Brazil, where under-registration is more common (MS 2004, 2005). Since fungal diseases are not bound by mandatory notification in the Brazilian Health System, the real situation of systemic mycoses in Brazil is difficult to assess. Brazil has a surface area of 8,547,403.5 km 2 , corresponding to approximately 47% of South America (IBGE 2000). Statistics based on skin tests or serological assays showed differences in the prevalence of infection in endemic areas as well as differences attributed to the kind of antigen used in the tests. Indeed, the utilisation of purified or crude antigens for the diagnosis of fungal infections may give rise to different results since crude preparations may increase cross-reactivity in sera from patients with other diseases.
205 citations
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TL;DR: A new method for host prediction based on co-occurrence associations is designed that reveals these viruses infect dominant members of the marine microbiome such as Prochlorococcus and Pelagibacter, and supports the recently proposed Piggyback-the-Winner model of reduced phage lysis at higher host densities.
Abstract: Marine viruses are key drivers of host diversity, population dynamics and biogeochemical cycling and contribute to the daily flux of billions of tons of organic matter. Despite recent advancements in metagenomics, much of their biodiversity remains uncharacterized. Here we report a data set of 27,346 marine virome contigs that includes 44 complete genomes. These outnumber all currently known phage genomes in marine habitats and include members of previously uncharacterized lineages. We designed a new method for host prediction based on co-occurrence associations that reveals these viruses infect dominant members of the marine microbiome such as Prochlorococcus and Pelagibacter. A negative association between host abundance and the virus-to-host ratio supports the recently proposed Piggyback-the-Winner model of reduced phage lysis at higher host densities. An analysis of the abundance patterns of viruses throughout the oceans revealed how marine viral communities adapt to various seasonal, temperature and photic regimes according to targeted hosts and the diversity of auxiliary metabolic genes.
205 citations
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TL;DR: The safety profile of tocilizumab-SC is consistent with the known and well-established safety profile with the exception of a higher incidence of ISR, which were more common with tocilizer-SC administration, and the most common adverse event was infection.
Abstract: Objectives This study compared the efficacy and safety of subcutaneous (SC) versus intravenous (IV) formulations of tocilizumab in patients with rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs (DMARD). Methods Patients (n=1262) were randomly assigned to receive tocilizumab-SC 162 mg weekly+placebo-IV every 4 weeks or tocilizumab-IV 8 mg/kg every 4 weeks+placebo-SC weekly in combination with traditional DMARD. The primary outcome was to demonstrate the non-inferiority of tocilizumab-SC to tocilizumab-IV with regard to the proportion of patients in each group achieving an American College of Rheumatology (ACR) 20 response at week 24 using a 12% non-inferiority margin (NIM). Secondary outcomes were disease activity score using 28 joints (DAS28), ACR responses, health assessment questionnaire scores and safety assessments. Results At week 24, 69.4% (95% CI 65.5 to 73.2) of tocilizumab-SC-treated patients versus 73.4% (95% CI 69.6 to 77.1) of tocilizumab-IV-treated patients achieved an ACR20 response (weighted difference between groups −4.0%, 95% CI −9.2 to 1.2); the 12% NIM was met. ACR50/70 responses, DAS28 and physical function improvements were comparable between the tocilizumab-SC and tocilizumab-IV groups. The safety profiles of tocilizumab-SC and tocilizumab-IV were similar, and the most common adverse event was infection. Injection-site reactions (ISR) occurred more frequently in the tocilizumab-SC group than in the tocilizumab-IV (placebo-SC) group. No anaphylaxis was reported over the 24 weeks. Conclusions Tocilizumab-SC 162 mg weekly demonstrated comparable efficacy to tocilizumab-IV 8 mg/kg. The safety profile of tocilizumab-SC is consistent with the known and well-established safety profile of tocilizumab-IV, with the exception of a higher incidence of ISR, which were more common with tocilizumab-SC administration.
205 citations
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Ghent University Hospital1, Ghent University2, University of Milan3, University of Belgrade4, Marche Polytechnic University5, University College London6, Royal Free London NHS Foundation Trust7, University of Zurich8, Universidad Peruana de Ciencias Aplicadas9, University of Utah10, McGill University11, Jewish General Hospital12, Lund University13, University of Turin14, Federal University of São Paulo15, University of Giessen16, University of Genoa17, Sapienza University of Rome18, University of Nebraska Medical Center19, St. Vincent's Health System20, Utrecht University21, Radboud University Nijmegen22
TL;DR: Experts in the field of capillaroscopy/microcirculation provide in this very consensus paper their view on image acquisition and analysis, different capillsaroscopic techniques, normal and abnormal capillARoscopic characteristics and their meaning, scoring systems and reliability of image acquisitionand interpretation.
205 citations
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TL;DR: Caregivers of elderly dialysis patients, especially of those on PD therapy, experience a significant burden and adverse effects on their quality of life and educational, social, and psychological support interventions should be considered to improve thequality of life of caregivers.
205 citations
Authors
Showing all 28240 results
Name | H-index | Papers | Citations |
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Majid Ezzati | 133 | 443 | 137171 |
Christian Guilleminault | 133 | 897 | 68844 |
Jean Rivier | 133 | 769 | 73919 |
Myron M. Levine | 123 | 789 | 60865 |
Werner Seeger | 114 | 1113 | 57464 |
Katherine L. Tucker | 106 | 683 | 39404 |
Michael Bader | 103 | 735 | 37525 |
Paulo A. Lotufo | 89 | 622 | 100527 |
Fernando Q. Cunha | 88 | 682 | 31501 |
Paul R. Sanberg | 87 | 635 | 29745 |
Harold A. Chapman | 87 | 191 | 26617 |
Ricardo T. Gazzinelli | 86 | 340 | 28233 |
Carlito B. Lebrilla | 86 | 495 | 25415 |
Roger S. McIntyre | 85 | 807 | 32040 |
Sergio Tufik | 85 | 1424 | 35174 |