Fifth Affiliated Hospital of Xinjiang Medical University

About: Fifth Affiliated Hospital of Xinjiang Medical University is a healthcare organization based out in Ürümqi, China. It is known for research contribution in the topics: Apoptosis & Population. The organization has 241 authors who have published 139 publications receiving 1190 citations.

Equisetum arvense L aqueous extract: a novel chemotherapeutic supplement for treatment of human colon carcinoma

Abstract: Introduction One of the plants that has long been considered by humans is Equisetum arvense L Equisetum arvense L is now recommended for external use to heal wounds and for internal use to relieve urinary tract and prostate disorders. Material and methods In the current study, the antioxidant, cytotoxicity, and anti-human ling cancer properties of Equisetum arvense were investigated in the in vitro condition. Total phenolic content, total flavonoid content, radical scavenging activity, and ferrous ion chelating were run to evaluate the antioxidant activity. MTT assay was chosen to investigate anticancer activity of the plant extract. Results The plant extract scavenged DPPH as a free radical with an IC50 of 12.3±0.7 µg/mL better than positive controls. The plant also was rich in phenolic compounds with an amount of 396.2±3.2 mg GAE/g for total phenolic content. In the MTT assay, human colorectal carcinoma (HCT-8 [HRT-18], Ramos.2G6.4C10, HT-29, and HCT 116) and normal cell lines (HUVEC) were used to study the cytotoxicity and anticancer potential of human colorectal over the Equisetum arvense L. The cell viability of Equisetum arvense L was very low against human colorectal carcinoma cell lines without any cytotoxicity on the normal (HUVEC) cell line. Conclusions The best anti-human colorectal carcinoma properties of Equisetum arvense L against the above cell lines was in the case of HT 29 cell line.

An analysis on the relationship between medical sharp injuries and job satisfaction among nursing staff

Abstract: Objective To investigate the risk factors of the medical sharp injuries and the correlation with job satisfaction among the nursing staff in one tertiary hospital in Xinjiang for the prevention-consciousness enhancement and the reduction of the occurrence of occupational exposure.Methods A cluster random sampling was adopted to investigate 189cases with questionnaire surveys on general status,occupational exposure and overall job satisfaction during one year.Results The occurrence rate of sharp injuries was 70.4%among 189nursing staff and the nursing staff with shorter working time,lower education and technical titles had more sharps injuries,averagely 2-5times.Most of the nursing staff had poor protective behavior,with some knowledge mainly from school education.The nurse staff with sharp injuries had lower job satisfaction and the nurse staff with lower job satisfaction was prone to the sharp injuries.Conclusion The preservice training of nursing students and the management of occupational protection should be further strengthened, and it is suggested to improve the nursing job satisfaction to reduce the occurrence of sharp injuries.

Genome-Scale Expression Pattern of Long Non-Coding RNAs in Chinese Uyghur Patients with Parkinson's Disease

Abstract: BACKGROUND Long non-coding RNAs (lncRNAs) are transcripts thought to regulate gene expression at the post-transcriptional level. Some lncRNAs are associated with Parkinson's disease (PD) and participate in pathological processes of PD. The incidence of PD is relatively high in members of the Uyghur minority living in Xingjiang province of China. This study measured the expression of lncRNAs in the peripheral blood cells of Chinese Uyghur individuals with and without PD and analyzed the possible function of these lncRNAs in the development of PD. MATERIAL AND METHODS Peripheral blood samples were collected from 55 Uyghur patients with PD and 55 healthy volunteers. Total RNA was extracted, and the levels of expression of whole-genome lncRNAs and mRNAs in 10 samples (5 PD and 5 controls) were determined by microarray method. The expression levels of lncRNAs in all 100 subjects were determined by qRT-PCR. The lncRNA expression profiles of PD patients were determined based on lncRNA microarray chip analysis, and differentially expressed lncRNAs were identified. The results of chip analysis were confirmed in a large clinical cohort. RESULTS Comparison of subjects with and without PD identified 32 significantly up-regulated and 18 significantly down-regulated lncRNAs in the PD group. GO analysis showed that mRNAs encoding proteins involved in the regulation of biological processes were differentially expressed, with the inflammatory immune response being the most significantly related pathway. CONCLUSIONS The expression of lncRNAs in peripheral blood differed significantly in PD patients and controls. These differentially expressed lncRNAs may play a role in the development of PD.

Calcification sign for prediction of benignity in pulmonary nodules: A meta-analysis.

Abstract: Background The calcification sign assessed by computed tomography appears to be a potential marker for benignities among patients diagnosed with pulmonary nodules (PNs). The following meta-analysis has been purposefully designed to figure-out the diagnostic value of the calcification signature as a way of identifying benignities from PNs. Methods Cochrane Library, Embase and PubMed were considered as a reference to obtain the required data from January 2000 until October 2020. Stata v12.0 was used as a standard tool for statistical assessment. Results Eleven retrospective studies were assessed via this meta-analysis, which included 6136 PNs (1827 benign and 4309 malignant). The pooled diagnostic odd ratios, positive likelihood ratio (PLR), negative likelihood ratio (NLR), sensitivity and specificity were 6.79, 6.06, 0.89, 13% and 98%, respectively. The value obtained for the area under the curve was 0.65, showing moderate overall diagnostic accuracy. A significant heterogeneity was found while calculating the pooled sensitivity (I2 = 85.5%), specificity (I2 = 75.0%), PLR (I2 = 59.0%), NLR (I2 = 79.5%) and DOR (I2 = 100.0%) in the current analysis. Sub-group analyses presented better PLR and specificity values for the study with a sample size ≥ 400. Deeks' funnel plot asymmetry test detected no potential evidence of significant publication bias (p = 0.091). Conclusions Calcification signs have been identified as moderate regulators corresponding to overall diagnostic performance (via marking a distinct differentiation between malignant and benign) for PNs. However, the manifestation of the calcification sign had a good directive property for benign PNs.