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Institution

Fifth Affiliated Hospital of Xinjiang Medical University

HealthcareÜrümqi, China
About: Fifth Affiliated Hospital of Xinjiang Medical University is a healthcare organization based out in Ürümqi, China. It is known for research contribution in the topics: Apoptosis & Population. The organization has 241 authors who have published 139 publications receiving 1190 citations.


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Journal ArticleDOI
TL;DR: In this article, the effect of pramipexole on behavior and central nervous system inflammatory cytokines of Parkinson's Disease (PD) model rats was studied, and it was observed that the degree of behavior improvement in treated group was greater than that in untreated group.

2 citations

Journal Article
TL;DR: In this paper, the authors evaluated the application of chronic disease health management in an urban community in the long-term management of diabetes mellitus (DM) based on the PRECEDE-PROCEED model.
Abstract: OBJECTIVE To evaluate the application of chronic disease health management in an urban community in the long-term management of diabetes mellitus (DM) based on the PRECEDE-PROCEED model. METHODS The PRECEDE-PROCEED model combines PRECEDE (predisposing, enabling and reinforcing constructs in educational diagnosis and evaluation) with PROCEED (policy, management and organization constructs in educational and environmental intervention). A total of 96 diabetic patients treated in our hospital were selected and divided into two groups by random number table, with 48 cases in each group. The routine group was given routine health management, while the PP group was given the urban community chronic disease health management based on the PRECEDE-PROCEED model in addition to the routine health management. After six months of management, the patients' effect was evaluated by comparing the blood glucose, diabetes knowledge, self-efficacy, self-management level and quality of life between the two groups. RESULTS The FPG, 2hPG and HbAlc levels of the PP group were lower than those of the routine group after six months of management (all P<0.05). The 6-month awareness rate, self-efficacy, self-management level and quality of life scores of the PP group were higher than those of the routine group (all P<0.05). CONCLUSION The chronic disease health management in urban communities based on the PRECEDE-PROCEED model in long-term diabetes management can effectively improve patients' diabetes knowledge, lower blood glucose levels, improve self-efficacy and self-management, and improve the quality of life.

1 citations

Journal ArticleDOI
TL;DR: It is demonstrated that the number of Bregs and the expression of TGF-β and IL-10 are enhanced in mice with CIA, a mouse model of collagen-induced arthritis.
Abstract: The aim of this study is to investigate changes in regulatory B cells (Bregs) and the expression of related cytokines such as interleukin-10 (IL-10) and transforming growth factor (TGF)-β in a mouse model of collagen-induced arthritis (CIA) A total 20 DBA/1 mice (6-8 weeks old) were randomly divided into control and CIA disease groups For the CIA disease group, animals were injected intradermally with chicken collagen type II and complete Freund's adjuvant The calculated arthritis index score of the CIA group was significantly higher than that in control group Hematoxylin and eosin staining showed tumid synovial cells with irregular arrangement and obvious hyperplasia, with a high degree of inflammatory cell infiltration in CIA model group Cytometric bead array technology and quantitative RT-PCR indicated that the levels of IL-10 and TGF-β in serum, and synovial cells were significantly increased in the CIA group The proportion of Bregs in the spleen of the CIA group was significantly increased compared to the control group In conclusion, our findings demonstrate that the number of Bregs and the expression of TGF-β and IL-10 are enhanced in mice with CIA

1 citations

Journal Article
TL;DR: RSR is suitable for the comprehensive evaluation of any material, scientifically reflecting the outpatient and inpatient medical services of hospitals in various regions of the whole country.
Abstract: Objective To evaluate outpatient and inpatient medical services of hospitals in various regions of the whole country in 2009 Methods RSR was applied to perform the statistical analysis Results The hospital outpatient and inpatient medical services in 31 provinces and municipalities( municipalities and autonomous regions)were divided into four grades The hospital outpatient and inpatient medical services were excellent in Guangdong,Yunnan,Hebei,Jiangsu,Hubei,Shandong,Henan,Hunan,good in Guangxi,Liaoning,Heilongjiang,Shaanxi,Jiangxi,Anhui,Guizhou,Sichuan,Zhejiang,fair in Qinghai,Beijing,Fujian,Shanxi,Inner Mongolia,Gansu,Chongqing and Xinjiang,and poor in Hainan,Tianjin,Ningxia,Tibet,Shanghai,Jilin Conclusion RSR is suitable for the comprehensive evaluation of any material,scientifically reflecting the outpatient and inpatient medical services of hospitals in various regions of the whole country

1 citations

Journal ArticleDOI
TL;DR: ATP13A2 rs2076603 SNV is associated with PD susceptibility, and the A allele is a PD protective factor in the Han population.
Abstract: Objective To analyze the ATP13A2 gene variants in the Han and Uyghur populations residing in Xinjiang and to determine their correlation with the risk of Parkinson's disease (PD). Methods Four ATP13A2 SNVs-rs56367069 (Arg294Gln), rs151117874 (Thr12Met), rs147277743 (Ala746Thr), and rs2076603-were analyzed in 218 patients (75 Uyghurs and 143 Hans) with sporadic PD and 234 healthy controls (90 Uyghurs and 144 Hans) by Sanger DNA sequencing. Results Only one Han patient harbored the AG genotype of the rs147277743 SNV, indicating a frequency of 0.46% in the Han population. In addition, this SNV was not associated with PD risk. The rs2076603 SNV was correlated with PD development, and the A allele in particular was significantly different across ethnicity and age. The rs56367069 and rs151117874 SNVs were not detected in the entire cohort. Conclusion ATP13A2 rs2076603 SNV is associated with PD susceptibility, and the A allele is a PD protective factor in the Han population.

1 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20222
202135
202019
201914
20189
201717