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Institution

Flinders University

EducationAdelaide, South Australia, Australia
About: Flinders University is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Health care. The organization has 12033 authors who have published 32831 publications receiving 973172 citations. The organization is also known as: Flinders University of South Australia.


Papers
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Journal ArticleDOI
TL;DR: The assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation, and the concept of deescalation of therapy is introduced in the treatment assessment scheme.
Abstract: This Executive Summary of the Global Strategy for the Diagnosis, Management, and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 report focuses primarily on the revised and novel parts of the document. The most significant changes include: (1) the assessment of chronic obstructive pulmonary disease has been refined to separate the spirometric assessment from symptom evaluation. ABCD groups are now proposed to be derived exclusively from patient symptoms and their history of exacerbations; (2) for each of the groups A to D, escalation strategies for pharmacologic treatments are proposed; (3) the concept of deescalation of therapy is introduced in the treatment assessment scheme; (4) nonpharmacologic therapies are comprehensively presented; and (5) the importance of comorbid conditions in managing chronic obstructive pulmonary disease is reviewed.

2,547 citations

Journal ArticleDOI
TL;DR: The authors present a new high-quality nucleon-nucleon potential with explicit charge dependence and charge asymmetry, which they designate Argonne {upsilon}{sub 18}.
Abstract: The authors present a new high-quality nucleon-nucleon potential with explicit charge dependence and charge asymmetry, which they designate Argonne {upsilon}{sub 18}. The model has a charge-independent part with fourteen operator components that is an updated version of the Argonne {upsilon}{sub 14} potential. Three additional charge-dependent and one charge-asymmetric operators are added, along with a complete electromagnetic interaction. The potential has been fit directly to the Nijmegen pp and np scattering data base, low-energy nn scattering parameters, and deuteron binding energy. With 40 adjustable parameters it gives a {chi}{sup 2} per datum of 1.09 for 4,301 pp and np data in the range 0--350 MeV.

2,409 citations

Journal ArticleDOI
TL;DR: “United the authors stand, United they fall”–Aesop.
Abstract: "United we stand, divided we fall."--Aesop. Aggregation-induced emission (AIE) refers to a photophysical phenomenon shown by a group of luminogenic materials that are non-emissive when they are dissolved in good solvents as molecules but become highly luminescent when they are clustered in poor solvents or solid state as aggregates. In this Review we summarize the recent progresses made in the area of AIE research. We conduct mechanistic analyses of the AIE processes, unify the restriction of intramolecular motions (RIM) as the main cause for the AIE effects, and derive RIM-based molecular engineering strategies for the design of new AIE luminogens (AIEgens). Typical examples of the newly developed AIEgens and their high-tech applications as optoelectronic materials, chemical sensors and biomedical probes are presented and discussed.

2,322 citations

Journal ArticleDOI
TL;DR: The need for surgical services in low- and middleincome countries will continue to rise substantially from now until 2030, with a large projected increase in the incidence of cancer, road traffic injuries, and cardiovascular and metabolic diseases in LMICs.

2,209 citations

Journal ArticleDOI
TL;DR: The cytokinesis-block method appears to be the procedure of choice for quantitating micronuclei in lymphocytes and was of no value for measuring pre-existing chromosomal damage present in vivo.
Abstract: The micronucleus technique has been proposed as a method for measurement of chromosomal damage in mitogen-stimulated human lymphocytes. Micronuclei require one cell division to be expressed and, consequently, the conventional micronucleus technique is very imprecise since the cells which have undergone only one division, and the micronuclei in them, cannot be identified separately from the total population of lymphocytes. To overcome this problem, two methods were developed to identify cells which have undergone their first mitosis. Using an autoradiographic technique, lymphocytes were pulse-labelled with [3H]thymidine at 48 h of culture, allowed to proceed through mitosis, identified by autoradiography between 72 and 84 h and micronuclei were scored in them. It was not possible to select a concentration of radiolabel which did not itself produce micronuclei and consequently the method was of no value for measuring pre-existing chromosomal damage present in vivo. However, it was capable of quantitating micronuclei produced by irradiation of lymphocytes in vitro. In the second method, cytokinesis was blocked using cytochalasin B. Micronuclei were scored in cytokinesis-blocked cells. These were easily recognisable owing to their binucleate appearance and a large number could be accumulated by adding 3.0 micrograms/ml cytochalasin B at 44 h and scoring at 72 h. Cytochalasin B did not itself produce micronuclei. The cytokinesis-block method was simple to perform; the 'in vivo' micronucleus frequency in normal individuals was 4.4 +/- 2.6 micronuclei/500 cytokinesis-blocked cells; and for lymphocytes irradiated in vitro there was a linear relationship between dose of radiation and number of induced micronuclei. The cytokinesis-block method appears to be the procedure of choice for quantitating micronuclei in lymphocytes.

1,764 citations


Authors

Showing all 12221 results

NameH-indexPapersCitations
Matthew Jones125116196909
Robert Edwards12177574552
Justin C. McArthur11343347346
Peter Somogyi11223242450
Glenda M. Halliday11167653684
Jonathan C. Craig10887259401
Bruce Neal10856187213
Alan Cooper10874645772
Robert J. Norman10375545147
John B. Furness10359737668
Richard J. Miller10341935669
Michael J. Brownstein10227447929
Craig S. Anderson10165049331
John Chalmers9983155005
Kevin D. Hyde99138246113
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202368
2022336
20212,761
20202,320
20191,943
20181,806