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Institution

Florida State University College of Arts and Sciences

About: Florida State University College of Arts and Sciences is a based out in . It is known for research contribution in the topics: Population & Poison control. The organization has 10947 authors who have published 13209 publications receiving 291678 citations.


Papers
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Journal ArticleDOI
TL;DR: A new statistical method for estimating divergence dates of species from DNA sequence data by a molecular clock approach is developed, and this dating may pose a problem for the widely believed hypothesis that the bipedal creatureAustralopithecus afarensis, which lived some 3.7 million years ago, was ancestral to man and evolved after the human-ape splitting.
Abstract: A new statistical method for estimating divergence dates of species from DNA sequence data by a molecular clock approach is developed. This method takes into account effectively the information contained in a set of DNA sequence data. The molecular clock of mitochondrial DNA (mtDNA) was calibrated by setting the date of divergence between primates and ungulates at the Cretaceous-Tertiary boundary (65 million years ago), when the extinction of dinosaurs occurred. A generalized least-squares method was applied in fitting a model to mtDNA sequence data, and the clock gave dates of 92.3 +/- 11.7, 13.3 +/- 1.5, 10.9 +/- 1.2, 3.7 +/- 0.6, and 2.7 +/- 0.6 million years ago (where the second of each pair of numbers is the standard deviation) for the separation of mouse, gibbon, orangutan, gorilla, and chimpanzee, respectively, from the line leading to humans. Although there is some uncertainty in the clock, this dating may pose a problem for the widely believed hypothesis that the pipedal creature Australopithecus afarensis, which lived some 3.7 million years ago at Laetoli in Tanzania and at Hadar in Ethiopia, was ancestral to man and evolved after the human-ape splitting. Another likelier possibility is that mtDNA was transferred through hybridization between a proto-human and a proto-chimpanzee after the former had developed bipedalism.

8,124 citations

Journal ArticleDOI
Sarah Djebali, Carrie A. Davis1, Angelika Merkel, Alexander Dobin1, Timo Lassmann, Ali Mortazavi2, Ali Mortazavi3, Andrea Tanzer, Julien Lagarde, Wei Lin1, Felix Schlesinger1, Chenghai Xue1, Georgi K. Marinov2, Jainab Khatun4, Brian A. Williams2, Chris Zaleski1, Joel Rozowsky5, Marion S. Röder, Felix Kokocinski6, Rehab F. Abdelhamid, Tyler Alioto, Igor Antoshechkin2, Michael T. Baer1, Nadav Bar7, Philippe Batut1, Kimberly Bell1, Ian Bell8, Sudipto K. Chakrabortty1, Xian Chen9, Jacqueline Chrast10, Joao Curado, Thomas Derrien, Jorg Drenkow1, Erica Dumais8, Jacqueline Dumais8, Radha Duttagupta8, Emilie Falconnet11, Meagan Fastuca1, Kata Fejes-Toth1, Pedro G. Ferreira, Sylvain Foissac8, Melissa J. Fullwood12, Hui Gao8, David Gonzalez, Assaf Gordon1, Harsha P. Gunawardena9, Cédric Howald10, Sonali Jha1, Rory Johnson, Philipp Kapranov8, Brandon King2, Colin Kingswood, Oscar Junhong Luo12, Eddie Park3, Kimberly Persaud1, Jonathan B. Preall1, Paolo Ribeca, Brian A. Risk4, Daniel Robyr11, Michael Sammeth, Lorian Schaffer2, Lei-Hoon See1, Atif Shahab12, Jørgen Skancke7, Ana Maria Suzuki, Hazuki Takahashi, Hagen Tilgner13, Diane Trout2, Nathalie Walters10, Huaien Wang1, John A. Wrobel4, Yanbao Yu9, Xiaoan Ruan12, Yoshihide Hayashizaki, Jennifer Harrow6, Mark Gerstein5, Tim Hubbard6, Alexandre Reymond10, Stylianos E. Antonarakis11, Gregory J. Hannon1, Morgan C. Giddings9, Morgan C. Giddings4, Yijun Ruan12, Barbara J. Wold2, Piero Carninci, Roderic Guigó14, Thomas R. Gingeras1, Thomas R. Gingeras8 
06 Sep 2012-Nature
TL;DR: Evidence that three-quarters of the human genome is capable of being transcribed is reported, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs that prompt a redefinition of the concept of a gene.
Abstract: Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.

4,450 citations

Journal ArticleDOI
TL;DR: The symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease are highlighted.

4,065 citations

Journal ArticleDOI
TL;DR: This review will attempt to address several key questions related to the use of ROS as signaling molecules in cells, including the dynamics and specificity of ROS signaling, networking of ROS with other signaling pathways, ROS signaling within and across different cells, ROS waves and the evolution of the ROS gene network.

1,879 citations

Journal ArticleDOI
TL;DR: This Opinion focuses on the possibility that ROS are beneficial to plants, supporting cellular proliferation, physiological function, and viability, and that maintaining a basal level of ROS in cells is essential for life.

1,828 citations


Authors

Showing all 10947 results

NameH-indexPapersCitations
Ralph B. D'Agostino2261287229636
Joseph Wang158128298799
Roy F. Baumeister157650132987
Stephen J. O'Brien153106293025
Adrian Bauman127106191151
Arnold I. Caplan12350670605
Omar K. Farha12361863896
Ken'ichi Nomoto12267552000
Andrew H. Paterson11949659373
Jian Liu117209073156
Liyuan Han11476665277
Jon H. Kaas11152646192
Jordan Grafman10954654241
Yoshinori Ohsumi10926766470
Howard Eichenbaum10827944172
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202228
20211,587
20201,382
20191,059
2018813
2017815