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Showing papers by "Ford Motor Company published in 2011"


Journal ArticleDOI
TL;DR: In this article, Nesiritide was not associated with an increase or a decrease in the rate of death and rehospitalization and had a small, nonsignificant effect on dyspnea when used in combination with other therapies.
Abstract: A b s t r ac t Background Nesiritide is approved in the United States for early relief of dyspnea in patients with acute heart failure. Previous meta-analyses have raised questions regarding renal toxicity and the mortality associated with this agent. Methods We randomly assigned 7141 patients who were hospitalized with acute heart failure to receive either nesiritide or placebo for 24 to 168 hours in addition to standard care. Coprimary end points were the change in dyspnea at 6 and 24 hours, as measured on a 7-point Likert scale, and the composite end point of rehospitalization for heart failure or death within 30 days. Results Patients randomly assigned to nesiritide, as compared with those assigned to placebo, more frequently reported markedly or moderately improved dyspnea at 6 hours (44.5% vs. 42.1%, P = 0.03) and 24 hours (68.2% vs. 66.1%, P = 0.007), but the prespecified level for significance (P≤0.005 for both assessments or P≤0.0025 for either) was not met. The rate of rehospitalization for heart failure or death from any cause within 30 days was 9.4% in the nesiritide group versus 10.1% in the placebo group (absolute difference, −0.7 percentage points; 95% confidence interval [CI], −2.1 to 0.7; P = 0.31). There were no significant differences in rates of death from any cause at 30 days (3.6% with nesiritide vs. 4.0% with placebo; absolute difference, −0.4 percentage points; 95% CI, −1.3 to 0.5) or rates of worsening renal function, defined by more than a 25% decrease in the estimated glomerular filtration rate (31.4% vs. 29.5%; odds ratio, 1.09; 95% CI, 0.98 to 1.21; P = 0.11). Conclusions Nesiritide was not associated with an increase or a decrease in the rate of death and rehospitalization and had a small, nonsignificant effect on dyspnea when used in combination with other therapies. It was not associated with a worsening of renal function, but it was associated with an increase in rates of hypotension. On the basis of these results, nesiritide cannot be recommended for routine use in the broad population of patients with acute heart failure. (Funded by Scios; ClinicalTrials.gov number, NCT00475852.)

1,046 citations


Journal ArticleDOI
TL;DR: The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer.
Abstract: The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer, which is the leading cause of cancer-related death in the United States Five-year survival rates approach 70% with surgical resection of stage IA disease; however, more than 75% of individuals have incurable locally advanced or metastatic disease, the latter having a 5-year survival of less than 5% It is plausible that treatment should be more effective and the likelihood of death decreased if asymptomatic lung cancer is detected through screening early enough in its preclinical phase For these reasons, there is intense interest and intuitive appeal in lung cancer screening with low-dose CT The use of survival as the determinant of screening effectiveness is, however, confounded by the well-described biases of lead time, length, and overdiagnosis Despite previous attempts, no test has been shown to reduce lung cancer mortality, an endpoint that circumvents screening biases and provides a definitive measure of benefit when assessed in a randomized controlled trial that enables comparison of mortality rates between screened individuals and a control group that does not undergo the screening intervention of interest The NLST is such a trial The rationale for and design of the NLST are presented

1,036 citations


Journal ArticleDOI
TL;DR: Scanned Bessel beams are used in conjunction with structured illumination and/or two-photon excitation to create thinner light sheets better suited to three-dimensional (3D) subcellular imaging.
Abstract: A key challenge when imaging living cells is how to noninvasively extract the most spatiotemporal information possible. Unlike popular wide-field and confocal methods, plane-illumination microscopy limits excitation to the information-rich vicinity of the focal plane, providing effective optical sectioning and high speed while minimizing out-of-focus background and premature photobleaching. Here we used scanned Bessel beams in conjunction with structured illumination and/or two-photon excitation to create thinner light sheets (<0.5 μm) better suited to three-dimensional (3D) subcellular imaging. As demonstrated by imaging the dynamics of mitochondria, filopodia, membrane ruffles, intracellular vesicles and mitotic chromosomes in live cells, the microscope currently offers 3D isotropic resolution down to ∼0.3 μm, speeds up to nearly 200 image planes per second and the ability to noninvasively acquire hundreds of 3D data volumes from single living cells encompassing tens of thousands of image frames.

1,007 citations


Journal ArticleDOI
TL;DR: The effects of various pharmacological and nonpharmacological interventions that can be used to preserve the favorable profile of a more compliant and less stiff aorta are reviewed.

746 citations


Journal ArticleDOI
TL;DR: In this paper, the authors report a comprehensive analysis of the global lithium resources and compare it to an assessment of global lithium demand from 2010 to 2100 that assumes rapid and widespread adoption of electric vehicles.
Abstract: Summary There is disagreement on whether the supply of lithium is adequate to support a future global fleet of electric vehicles. We report a comprehensive analysis of the global lithium resources and compare it to an assessment of global lithium demand from 2010 to 2100 that assumes rapid and widespread adoption of electric vehicles. Recent estimates of global lithium resources have reached very different conclusions. We compiled data on 103 deposits containing lithium, with an emphasis on the 32 deposits that have a lithium resource of more than 100,000 tonnes each. For each deposit, data were compiled on its location, geologic type, dimensions, and content of lithium as well as current status of production where appropriate. Lithium demand was estimated under the assumption of two different growth scenarios for electric vehicles and other current battery and nonbattery applications. The global lithium resource is estimated to be about 39 Mt (million tonnes), whereas the highest demand scenario does not exceed 20 Mt for the period 2010 to 2100. We conclude that even with a rapid and widespread adoption of electric vehicles powered by lithium-ion batteries, lithium resources are sufficient to support demand until at least the end of this century.

438 citations


Journal ArticleDOI
TL;DR: The vehicle path trajectory in these data sets contains several large- and small-scale loop closures, which should be useful for testing various state-of-the-art computer vision and simultaneous localization and mapping algorithms.
Abstract: In this paper we describe a data set collected by an autonomous ground vehicle testbed, based upon a modified Ford F-250 pickup truck. The vehicle is outfitted with a professional (Applanix POS-LV) and consumer (Xsens MTi-G) inertial measurement unit, a Velodyne three-dimensional lidar scanner, two push-broom forward-looking Riegl lidars, and a Point Grey Ladybug3 omnidirectional camera system. Here we present the time-registered data from these sensors mounted on the vehicle, collected while driving the vehicle around the Ford Research Campus and downtown Dearborn, MI, during November-December 2009. The vehicle path trajectory in these data sets contains several large- and small-scale loop closures, which should be useful for testing various state-of-the-art computer vision and simultaneous localization and mapping algorithms.

343 citations


Patent
06 Oct 2011
TL;DR: In this article, a vehicle guidance system is provided with a controller configured to receive input indicative of a relative position between a charging port and a charging pad, and to provide output indicating a distance vector there between in response to the input.
Abstract: A vehicle guidance system is provided with a controller configured to receive input indicative of a relative position between a charging port and a charging pad, and to provide output indicative of a distance vector therebetween in response to the input. An interface communicates with the controller and is configured to display a base element representing the charging port and target element representing the charging pad positioned relative to each other according to the distance vector.

251 citations


Patent
28 Jun 2011
TL;DR: In this paper, a method and system for fuel vapor control in a hybrid vehicle (HEV) is described, which includes a fuel tank isolation valve, which is normally closed to isolate storage of refueling from storage of diurnal vapors.
Abstract: A method and system for fuel vapor control in a hybrid vehicle (HEV). The HEV fuel vapor recovery system includes a fuel tank isolation valve, which is normally closed to isolate storage of refueling from storage of diurnal vapors. The method for fuel vapor control includes selectively actuating the fuel tank isolation valve during interrelated routines for refueling, fuel vapor purging, and emission system leak detection diagnostics to improve regulation of pressure and vacuum the HEV fuel vapor recovery system.

237 citations


Patent
06 May 2011
TL;DR: In this article, a trim molding for an exterior surface of a vehicle is provided with a trim body formed of a light transmissive material for coupling to the exterior surface, the trim body having an interior side and an exterior side.
Abstract: A trim molding for an exterior surface of a vehicle is provided with a trim body formed of a light transmissive material for coupling to the exterior surface, the trim body having an interior side and an exterior side. A variable light source is disposed on the interior side of the trim body. A one-way mirror is disposed on the exterior side of the trim body having an opaque appearance from outside the trim molding in bright ambient lighting conditions. The one-way mirror transmits light from the variable light source therethrough. The variable light source provides a first lighting level for accenting the exterior surface of the vehicle in dark ambient lighting conditions. The variable light source provides a second lighting level greater than the first lighting level to illuminate the ground near the vehicle to assist in vehicle entry in dark ambient lighting conditions.

194 citations


Journal ArticleDOI
TL;DR: The authors showed that record grain prices in 2008 were not caused by increased biofuel production, but were actually the result of a speculative bubble related to high petroleum prices, a weak US dollar, and increased volatility due to commodity index fund investments.
Abstract: The prices of some grain commodities more than doubled from March 2007 to March 2008. Increased food prices coincided with increasing global biofuel production, leading to speculation that biofuel production was responsible for the increased food prices. However, over the six-month period after March 2008, grain prices declined by 50% while biofuel production continued to increase. It is not possible to reconcile claims that biofuel production was the major factor driving food price increases in 2007–2008 with the decrease in food prices and increase in biofuel production since mid-2008. The available data suggests that record grain prices in 2008 were not caused by increased biofuel production, but were actually the result of a speculative bubble related to high petroleum prices, a weak US dollar, and increased volatility due to commodity index fund investments. Many factors converged in 2007–2008 to increase food and related commodity prices including increased demand, decreased supply, and increased production costs driven by higher energy and fertilizer costs. Disentangling these factors and providing a precise quantification of their contributions is a difficult, perhaps impossible, task. In 2008, several reports were published by governmental and international agencies that speculated on the cause of increased food prices worldwide. Taken together, the available analyses suggest that biofuel production had a modest (3–30%) contribution to the increase in commodity food prices observed up to mid-2008. The development of second-generation biofuels (e.g., cellulosic ethanol) which use non-food residual biomass or non-food crops should mitigate any future impact of biofuel production on food prices.

179 citations


Patent
28 Jun 2011
TL;DR: In this paper, a system and method of controlling a vehicle with a trailer comprises determining the presence of a trailer, generating an oscillation signal indicative of trailer swaying relative to the vehicle, and subsequently, iteratively generating a penalty function for the weighted dynamic control signal as a function of the trailer sway response.
Abstract: A system and method of controlling a vehicle with a trailer comprises determining the presence of a trailer, generating an oscillation signal indicative of trailer swaying relative to the vehicle, generating an initial weighted dynamic control signal for a vehicle dynamic control system in response to the oscillation signal, operating at least one vehicle dynamic system according to the dynamic control signal, and thereafter, iteratively generating a penalty function for the weighted dynamic control signal as a function of the oscillation signal response. A neural network with an associated trainer modifies the dynamic control signal as a function of trailer sway response.

Journal ArticleDOI
TL;DR: Two chemical mechanisms for OH radical attack on the Nafion polymer are proposed and all have all been observed by F NMR in the fuel cell exit gases along with the decrease in pH expected from the mechanism.
Abstract: We report results of quantum mechanics (QM) mechanistic studies of Nafion membrane degradation in a polymer electrolyte membrane (PEM) fuel cell. Experiments suggest that Nafion degradation is caused by generation of trace radical species (such as OH●, H●) only when in the presence of H2, O2, and Pt. We use density functional theory (DFT) to construct the potential energy surfaces for various plausible reactions involving intermediates that might be formed when Nafion is exposed to H2 (or H+) and O2 in the presence of the Pt catalyst. We find a barrier of 0.53 eV for OH radical formation from HOOH chemisorbed on Pt(111) and of 0.76 eV from chemisorbed OOHad, suggesting that OH might be present during the ORR, particularly when the fuel cell is turned on and off. Based on the QM, we propose two chemical mechanisms for OH radical attack on the Nafion polymer: (1) OH attack on the S–C bond to form H2SO4 plus a carbon radical (barrier: 0.96 eV) followed by decomposition of the carbon radical to form an epoxid...

Proceedings ArticleDOI
03 Oct 2011
TL;DR: A speed prediction algorithm, NNTM-SP (Neural Network Traffic Modeling-Speed Prediction) that trained with the historical traffic data and is capable of predicting the vehicle speed profile with the current traffic information is presented.
Abstract: Prediction of the traffic information such as flow, density, speed, and travel time is important for traffic control systems, optimizing vehicle operations, and the individual driver. Prediction of future traffic information is a challenging problem due to many dynamic contributing factors. In this paper, various methodologies for traffic information prediction are investigated. We present a speed prediction algorithm, NNTM-SP (Neural Network Traffic Modeling-Speed Prediction) that trained with the historical traffic data and is capable of predicting the vehicle speed profile with the current traffic information. Experimental results show that the proposed algorithm gave good prediction results on real traffic data and the predicted speed profile shows that NNTM-SP correctly predicts the dynamic traffic changes.

Journal ArticleDOI
TL;DR: In dogs with advanced heart failure, CSB activation improves global LV function and partially reverses LV remodeling both globally and at cellular and molecular levels.
Abstract: Background— Autonomic abnormalities exist in heart failure and contribute to disease progression. Activation of the carotid sinus baroreflex (CSB) has been shown to reduce sympathetic outflow and augment parasympathetic vagal tone. This study tested the hypothesis that long-term electric activation of the CSB improves left ventricular (LV) function and attenuates progressive LV remodeling in dogs with advanced chronic heart failure. Methods and Results— Studies were performed in 14 dogs with coronary microembolization-induced heart failure (LV ejection fraction ≈25%). Eight dogs were chronically instrumented for bilateral CSB activation using the Rheos System (CVRx Inc, Minneapolis, Minn) and 6 were not and served as controls. All dogs were followed for 3 months, and none received other background therapy. During follow-up, treatment with CSB increased LV ejection fraction 4.0±2.4% compared with a reduction in control dogs of −2.8±1.0% ( P <0.05). Similarly, treatment with CSB decreased LV end-systolic volume −2.5±2.7 mL compared with an increase in control dogs of 6.7±2.9 mL ( P <0.05). Compared with control, CSB activation significantly decreased LV end-diastolic pressure and circulating plasma norepinephrine, normalized expression of cardiac β1-adrenergic receptors, β-adrenergic receptor kinase, and nitric oxide synthase and reduced interstitial fibrosis and cardiomyocyte hypertrophy. Conclusions— In dogs with advanced heart failure, CSB activation improves global LV function and partially reverses LV remodeling both globally and at cellular and molecular levels.

Patent
12 May 2011
TL;DR: In this paper, the position of one or more valves and throttles may be adjusted based on the selective deactivation to reduce back-flow through the disabled cylinders while also maintaining conditions of a downstream exhaust catalyst.
Abstract: Methods and systems are provided for selecting a group of cylinders for selective deactivation, in a variable displacement engine system, based at least on a regeneration state of an exhaust catalyst. The position of one or more valves and throttles may be adjusted based on the selective deactivation to reduce back-flow through the disabled cylinders while also maintaining conditions of a downstream exhaust catalyst. Pre-ignition and knock detection windows and thresholds may also be adjusted based on the deactivation to improve the efficiency of knock and pre-ignition detection.

Patent
13 Jun 2011
TL;DR: In this paper, the authors proposed a method to determine a route for efficient energy consumption based on the route data and the consumption influencing parameters, which minimizes the consumption of the energy source for the vehicle.
Abstract: Various embodiments relate to determining a route for efficient energy consumption. Data defining one or more routes and one or more consumption influencing parameters which influence a consumption of an energy source of the vehicle along the one or more routes may be received at a vehicle computer. Based on the route data and the consumption influencing parameters, at least one route which minimizes the consumption of the energy source for the vehicle may be determined. For the at least one route, one or more braking strategies may be determined for implementation by a vehicle operator in the vehicle in accordance with reducing the consumption of the vehicle energy source. The one or more braking strategies may be output in the vehicle.

Journal ArticleDOI
TL;DR: This feasibility study investigated unobtrusive capacitive ECG measurements in an automotive environment and found that an array of sensors is needed that can adapt to the different drivers and sitting positions.
Abstract: Modern automobiles include an increasing number of assistance systems to increase the driver's safety. This feasibility study investigated unobtrusive capacitive ECG measurements in an automotive environment. Electrodes integrated into the driving seat allowed to measure a reliable ECG in 86% of the drivers; when only (light) cotton clothing was worn by the drivers, this value increased to 95%. Results show that an array of sensors is needed that can adapt to the different drivers and sitting positions. Measurements while driving show that traveling on the highway does not distort the signal any more than with the car engine turned OFF, whereas driving in city traffic results in a lowered detection rate due to the driver's heavier movements. To enable robust and reliable estimation of heart rate, an algorithm is presented (based on principal component analysis) to detect and discard time intervals with artifacts. This, then, allows a reliable estimation of heart rate of up to 61% in city traffic and up to 86% on the highway: as a percentage of the total driving period with at least four consecutive QRS complexes.


Journal ArticleDOI
TL;DR: In this article, the potential generation of ultrafine particles from the tire road interface was investigated during real driving using an instrumented sport utility vehicle equipped with summer tires, where particle concentrations with high temporal resolution inside the wheel housing were measured inside a wheel housing while driving on a regular asphalt road.

Patent
26 Jul 2011
TL;DR: A computer-implemented method for determining that a connection to an update server should be established is presented in this article, which also includes establishing a wireless connection with the update server.
Abstract: A computer-implemented method includes determining that a connection to an update server should be established. The method also includes establishing a wireless connection with the update server. The method further includes sending at least a VIN number to the update server and downloading one or more module updates corresponding to the sent VIN number. Also, the method includes verifying the one or more downloaded updates. The method further includes flashing one or more modules to which the one or more updates correspond. Additionally, the method includes verifying the functionality of each module which has been flashed.

Journal ArticleDOI
TL;DR: In this paper, the authors report the reaction pathways and barriers for the oxygen reduction reaction (ORR) on platinum, both for gas phase and in solution, based on quantum mechanics calculations (PBE-DFT) on semi-infinite slabs.
Abstract: We report the reaction pathways and barriers for the oxygen reduction reaction (ORR) on platinum, both for gas phase and in solution, based on quantum mechanics calculations (PBE-DFT) on semi-infinite slabs. We find a new mechanism in solution: O_2 → 2O_(ad) (E_(act) = 0.00 eV), O_(ad) + H_2O_(ad) → 2OH_(ad) (E_(act) = 0.50 eV), OH_(ad) + H_(ad) → H_2O_(ad) (E_(act) = 0.24 eV), in which OH_(ad) is formed by the hydration of surface O_(ad). For the gas phase (hydrophilic phase of Nafion), we find that the favored step for activation of the O_2 is H_(ad) + O_(2ad) → HOO_(ad) (E_(act) = 0.30 eV) → HO_(ad) + O_(ad) (E_(act) = 0.12 eV) followed by O_(ad) + H_2O_(ad) → 2OH_(ad) (E_(act) = 0.23 eV), OH_(ad) + H_(ad) → H_2O_(ad) (E_(act) = 0.14 eV). This suggests that to improve the efficiency of ORR catalysts, we should focus on decreasing the barrier for Oad hydration while providing hydrophobic conditions for the OH and H_2O formation steps.

Patent
10 Nov 2011

Journal ArticleDOI
TL;DR: In this article, a micrometer-resolved Raman mapping of a transition-metal-based oxide positive electrode, Li1-x(NiyCozAl1-y-z)O2, maintained at different state-of-charge (SOC) levels is presented.
Abstract: Current lithium-ion battery technology is gearing towards meeting the robust demand of power and energy requirements for all-electric transportation without compromising on the safety, performance, and cycle life. The state-of-charge (SOC) of a Li-ion cell can be a macroscopic indicator of the state-of-health of the battery. The microscopic origin of the SOC relates to the local lithium content in individual electrode particles and the effective ability of Li-ions to transport or shuttle between the redox couples through the cell geometric boundaries. Herein, micrometer-resolved Raman mapping of a transition-metal-based oxide positive electrode, Li1-x(NiyCozAl1-y-z)O2, maintained at different SOCs, is shown. An attempt has been made to link the underlying changes to the composition and structural integrity at the individual particle level. Furthermore, an SOC distribution at macroscopic length scale of the electrodes is presented.

Patent
06 Jan 2011
TL;DR: In this paper, a computer-implemented method, executable by a vehicle associated computing system, includes receiving a request for display of local refueling points and determining current coordinates of vehicle and determining one or more fuel point locations within a defined map range.
Abstract: A computer-implemented method, executable by a vehicle associated computing system, includes receiving a request for display of local refueling points. The method also includes determining current coordinates of vehicle and determining one or more fuel point locations within a defined map range. The method additionally includes displaying a map display containing the current vehicle location and the location of the one or more fuel point locations.

Journal ArticleDOI
TL;DR: In this article, a mathematical model of a lithium-ion cell was used to analyze pulse and relaxation behavior in cells designed for hybrid-electric-vehicle propulsion, and the results indicated that the ohmic voltage loss in the positive electrode is the dominant contributor to cell overvoltage in the first instances of a pulse.

Journal ArticleDOI
TL;DR: In this article, the authors explored the capabilities of DSIF in terms of improving the geometric accuracy as compared to single point incremental forming by using a novel toolpath strategy in which the sheet is locally squeezed between the two tools.
Abstract: Single point incremental forming (SPIF) is plagued by an unavoidable and unintended bending in the region of the sheet between the current tool position and the fixture. The effect is a deformation of the region of the sheet in between the formed area and the fixture as well as deformation of the already formed portion of the wall, leading to significant geometric inaccuracy in SPIF. Double sided incremental forming (DSIF) uses two tools, one on each side of the sheet to form the sheet into the desired shape. This work explores the capabilities of DSIF in terms of improving the geometric accuracy as compared to SPIF by using a novel toolpath strategy in which the sheet is locally squeezed between the two tools. Experiments and simulations are performed to show that this strategy can improve the geometric accuracy of the component significantly by causing the deformation to be stabilized into a local region around the contact point of the forming tool. At the same time an examination of the forming forces indicates that after a certain amount of deformation by using this strategy a loss of contact occurs between the bottom tool and the sheet. The effects of this loss of contact of the bottom tool on the geometric accuracy and potential strategies, in order to avoid this loss of contact, are also discussed.

Patent
07 Feb 2011
TL;DR: In this article, an integrated stability control system using the signals from an integrated sensing system for an automotive vehicle includes a plurality of sensors sensing the dynamic conditions of the vehicle, including an IMU sensor cluster, a steering angle sensor, wheel speed sensors, any other sensors required by subsystem controls.
Abstract: An integrated stability control system using the signals from an integrated sensing system for an automotive vehicle includes a plurality of sensors sensing the dynamic conditions of the vehicle. The sensors include an IMU sensor cluster, a steering angle sensor, wheel speed sensors, any other sensors required by subsystem controls. The signals used in the integrated stability controls include the sensor signals; the roll and pitch attitudes of the vehicle body with respect to the average road surface; the road surface mu estimation; the desired sideslip angle and desired yaw rate from a four-wheel reference vehicle model; the actual vehicle body sideslip angle projected on the moving road plane; and the global attitudes. The demand yaw moment used to counteract the undesired vehicle lateral motions (under-steer or over-steer or excessive side sliding motion) are computed from the above-mentioned variables. The braking control is a slip control whose target slip ratios at selective wheels or wheel are directly generated from the request brake pressures computed from the demand yaw moment.



Patent
01 Apr 2011
TL;DR: In this article, the authors present a method for using and managing aggregated electronic calendars and task lists in a vehicle, where the electronic calendar for the identified vehicle occupant and the contact of the vehicle occupant may be displayed in the vehicle.
Abstract: Various embodiments may include methods and systems for using and managing aggregated electronic calendars and task lists in a vehicle. The method may include receiving information at a vehicle computer identifying at least one vehicle occupant. Further, calendar data may be received at the computer including at least two electronic calendars each associated with the at least one vehicle occupant and at least one contact of the vehicle occupant. The electronic calendar for the identified vehicle occupant and the contact of the vehicle occupant may be displayed in the vehicle.